جستجوی مقالات مرتبط با کلیدواژه "کورکومین" در نشریات گروه "مواد و متالورژی"

Use of drug-carrying scaffolds in regenerative medicine induces simultaneous tissue regeneration and drug release at the injury site. In this research, nanofibrous scaffolds based on poly-caprolactone/decellularized Wharton’s jelly matrix (PCL/DWJM) with a weight ratio of 20:80 containing curcumin were prepared through electrospinning method. Nanofibrous scaffolds were then compared in terms of morphology, physicochemical properties, and drug release in the presence and absence of MWCNTs-COOH. The morphology of the fibers, observed using a Scanning Electron Microscope (SEM), shows that the presence of curcumin and MWCNT increases the conductivity of the solution and charge density as well, thereby reducing the diameter of nanofibers and facilitating the electrospinning process. Infrared Spectroscopy (FTIR) indicated the interaction between the functional groups in curcumin, DWJM, and MWCNT, hence an improvement in the tensile strength of the scaffold. Addition of MWCNT-COOH increased the tensile strength of the scaffold by about two times that of the scaffold without ceramics. Curcumin, as a lipophilic substance in the PCL/DWJM structure, prevents the reduction of the contact angle while addition of MWCNT-COOH decreases the contact angle of water. The drug release evaluation revealed that compared to the polymer scaffold without ceramics, the amount of curcumin released from the scaffold containing MWCNT-COOH enhanced due to the increased repulsion of the negative charges between the oxygen anion and carboxylate anion.

In this study, Fe3O4/SiO2/GO nanocomposites were investigated as a pH-responsive nanocarrier for the loading and release of the anticancer drug curcumin. Fe3O4/SiO2/GO nanoparticles were synthesized by thermal treatment method and characterized and drug delivery properties were investigated using VSM, FTIR, SEM, UV-visible, EDX, and, TEM techniques. The size of Fe3O4/SiO2/GO nanocomposites was about 56 nm. The X-ray diffraction pattern results of Fe3O4/SiO2/GO nanocomposite showed the presence of crystalline, cubic, and tetragonal phases with a crystal size of 14.79 nm, and the VSM results showed the ferromagnetic behavior at room temperature .The results of FTIR analysis and SEM images before and after drug loading confirmed the functionalization of nanocomposites with curcumin. The loading capacity of curcumin on the surface of Fe3O4/SiO2/GO nanocomposites was approximately 19.21%. The curcumin release from nanocarriers increased from 28% to 68% by changing pH from 7.4 to 4.8. Results of the MTT test showed that nanocarriers are significantly toxic on U87 cell lines in a dose-dependent manner, while they are relatively safe for human fibroblast cells.

In this study, curcumin/chitosan (Cs/Cr) nanocomplex with different weight percentages Cs/Cr (1:1) (sample A) and Cs/Cr (2:1) (sample B) by drug-poly saccharide complex method were fabricated and encapsulated into chitosan/alginate hydrogel and then the samples were evaluated. The morphology and functional group of the samples surface were evaluated via the scanning electron microscopy (SEM and FESEM) and fourier transform infrared spectroscopy (FTIR), respectively. The average hydrodynamic diameter of nancomplex A and B by the dynamic light scattering (DLS) were measured 80nm and 45 nm, respectively and their zeta potentials were obtained mV and mV, respectively. For characterization of Cs/Cr nano complex loaded hydrogel, the water vapour transmission rate (WVTR) and the swelling test in PBS were performed. The results indicated that hydrogel containing nanocomplex B with high absorbing fluids (2049%) and good WVTR (2300 g/m2/day) can be suitable for creating a wet environment for wound healing. Also, in vitro release studies by HPLC method was performed for evaluation of curcumin release from nano complex and the results showed a sustained release without initial burst release. To study the release mechanism of curcumin from nanocomplex, data obtained from release test were fitted to Korsmeyer-Peppas kinetics model. Also, the encapsulation efficiency of curcumin in nanocomplex was meseared 80% that the results indicated a high curcumin loading in nanocomplex. Finally, the viability and proliferation of fibroblast cell line (L929) on nano complex surface was evaluated by MTT assay and the results did not showed any cytotoxicity. Therefore, the hydrogel containing Cs/Cr nano complex can be a good choice as wound dressing for rapid healing.