جستجوی مقالات مرتبط با کلیدواژه « اسید نوکلئیک » در نشریات گروه « بیوتکنولوژی و ژنتیک گیاهی »

Nanotechnology, the manipulation of matter at the anatomical and molecular levels, has paved the way for the creation of materials with unique and enhanced properties. One of its significant applications is in the realm of nano-biotechnology, where various subfields, such as nanostructures, play a crucial role in fields like biotechnology and structural and cellular genomics. Nano-biotechnology offers a groundbreaking approach to research by allowing scientists to introduce chemicals and components into cells and fabricate novel materials through innovative techniques like assembling. Particularly noteworthy is its contribution to the in vivo administration of Nucleic Acid (NA) therapeutics. Advanced nanoscale biotechnology strategies have played a pivotal role in this domain by providing precise control over crucial parameters such as dimension, charge, drug loading, and response to external signals of delivery transporters. The integration of cutting-edge nanoscale biotechnology in the field of cancer immunotherapy holds significant promise for overcoming obstacles in NA treatment. This involves addressing challenges related to the clinical and preclinical research of different nanocarriers. This article serves as a concise overview, delving into the characteristics and encountered difficulties associated with various nanocarriers during clinical and preclinical investigations. The paper discusses a range of NA methods and elucidates how state-of-the-art nanoscale biotechnology actively supports and enhances NA treatment. By manipulating the physical and chemical attributes of delivery transporters, nanotechnology allows for the optimization of therapeutic outcomes, making it an invaluable tool in the advancement of medical research. In conclusion, the marriage of nanotechnology and biotechnology, specifically in the field of nano-biotechnology, opens up new avenues for scientific exploration and medical advancements. The precision and versatility offered by nanoscale techniques hold immense potential in revolutionizing the landscape of NA therapeutics, paving the way for more effective and targeted treatments. The ongoing progress in cutting-edge Nanobiotechnology (N-Bio-Tech) exemplifies the relentless pursuit of solutions to some of the most significant challenges in medical science, particularly in the realm of cancer immunotherapy.

Viruses are the amazing particles in nature that is designed to reproduce with a minimal genetic set. This vital process is very complex and requires the time and coordinated activities of a number of virus and host proteins. In order to the genome packaging, the virus protein subunits interact with each other and with viral nucleic acids. The general principle in packaging is the interaction between the structure of coat protein and a specific signal in RNA. Replication of +ssRNA viruses and their nucleocapsid assembly occurs in the cytoplasm and requires Pro-Pro and Pro-RNA interactions. The packaging process in them is spontaneous and does not require ATP. The interaction between the coat protein subunits and the genomic RNA is controlled by a unique structure in the sequence that is highly desired to interaction with the coat protein. The presence of these unique structures in the viral nucleic acid, called the packaging signal or OAS (origin of assembly sequence), causes viral nucleic acid to be distinguished from other cellular RNA molecules in the region which assembly takes place. General knowledge of the precise mechanisms of viruses, the configuration and aggregation of viruses, and the packing of their genomes that lead to the formation of stable viral structures is an important prerequisite for understanding the overall biology of viruses.