جستجوی مقالات مرتبط با کلیدواژه "plant extracts" در نشریات گروه "شیلات"

The drug-induced liver injury (DILI) has a wide range of clinical presentations, from asymptomatic liver enzyme elevations to cirrhosis. Herbal dietary supplements may be beneficial to reduce the risk of hepatotoxicity. This study aimed to evaluate the effects of different doses of clove extracts on humoral factors in rats with hepatotoxicity induced by thioacetamide.

In this experimental study, rats were divided into nine groups (10 rats per each). The Control group received no treatment. The Sham group was treated with oral administration of distilled water (0.5 ml) for 21 days. The positive control group received thioacetamide (50 mg/kg for three days) intraperitoneally. The clove group was divided into three subgroups and given daily oral administrations of 50, 150, and 300 mg/kg of clove hydroalcoholic extracts (for 21 days). Rats in the experimental group were divided into three subgroups and subjected to 50 mg/kg thioacetamide injection after receiving hydroalcoholic extracts of clove (50, 150, and 300 mg/kg, respectively) for 21 days in the last three days. All rats were sacrificed after 48 hours to measure liver function parameters (aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, total plasma protein, and albumin).

The rats that received thioacetamide showed liver damage by increased serum liver biomarkers and decreased levels of total plasma protein and albumin compared to the control group. The different doses of clove extract resulted in a significant improvement of liver damage by reduced serum liver enzymes levels and increased total plasma protein and albumin.

Oral administration of the different doses of the clove extract (50, 150, and 300 mg/kg) for 21 consecutive days could significantly improve the changes associated with serum biomarkers of hepatotoxicity.

Artemisia argyi and Houttuynia cordata Thunb are common herbs in most regions of China. In order to test their composite effect as additives on fish, the effects of their extracts mixture on growth performance, antioxidant activity, serum and hepatic lipid levels, and gut bacteria in juvenile grass carp were evaluated. 180 fish were divided into 9 tanks with 3 replicate tanks per treatment, and fed with a control diet (A0) or one of two treatment diets containing 500 (A1) or 1000 mg/kg (A2) mixture of extracts, with equal mass of A. argyi and H. cordata, for 8 weeks. Water flow rate was 8.0 L/min, and water quality parameters were in normal range. At the end of feeding trial, fish weight gain, feed conversion ratio, and survival rate showed no difference among all groups. Significantly higher catalase (CAT) activity and lower malondialdehyde (MDA) content were observed in A1 and A2 groups. Serum triglyceride content was much lower in the A1 group and total cholesterol was lower in experimental groups compared with the control group. Transmission electron microscopy showed that the hepatic lipid droplets were smaller in the experimental groups. High-throughput sequencing identified 10 predominant phyla from gut samples, and Fusobacteria, Bacteroidetes, and Proteobacteria were the most dominant groups. Compared with the control group, in A1 group operational taxonomic unit (OTU) number, species richness (Chao1, and ACE), and α diversity (Shannon index) were higher, and gut bacteria composition was altered in A1 and A2 groups at phylum and genus levels. These results indicated that the extracts mixture of A. argyi and H. cordata can increase antioxidant activity, lower serum and hepatic lipid levels, and improve gut bacteria composition, which can be used as a green additive for grass carp.

This study aims to get a comprehensive evaluation of the growth promoting effects and the hypoxic stress relief potentiality of Moringa oleifera aqueous extracts. Oreochromis niloticus fingerlings were arbitrarily allocated into five duplicated fish groups (30 fish tank-1). The fish groups were labeled according to the M. oleifera aqueous extract dietary inclusion level (G1:G5). MOAE had fundamentally promoted tilapia growth. Serum total protein levels were considerably higher in the M. oleifera fed fish, whereas the levels of liver enzymes diminished significantly in G5 fish. Additionally, the dietary M. oleifera resulted in a noticeable hypoglycemic effect together with a pronounced decline in the antioxidant activities. The use of M. oleifera supplemented diet decreased the hypoxia-related stress as conveyed by the gradual descent in the serum cortisol levels of the hypoxic-stressed tilapia. This study proposes the potentiality of M. oleifera aqueous extract as a growth promoter, antistress and antioxidants. It also validates its safe application in commercial tilapia culture. Future study is required to comprehend the influence of this plant extract in relieving chronic stress and its possible toxic effect as well. Feasibility study for its commercial usage is required too.