جستجوی مقالات مرتبط با کلیدواژه « Parkinson's Disease » در نشریات گروه « کشاورزی »

Bee venom has been considered as a healing medicine since ancient times. In fact, bee therapy (treatment with bee products) has been a common term in past civilizations. Parkinson's disease is one of the progressive neurological disorder. One of the pathological reasons for this neurological disease is the destruction of nerve cells that contain a chemical substance called dopamine, which is produced from certain nuclei in the brain called the substantia nigra. The messages from this chemical are sent from the brain to the motor muscles. Therefore, when a person suffers from Parkinson's disease, the amount of dopamine release decreases step by step and we will see numerous movement problems in the person. Since the worsening process of this disease takes place slowly, therefore, using a suitable treatment process will greatly help the sick person to have a minimal normal life. In numerous studies, countless therapeutic effects of bee venom have been stated in relation to arthritis, neurological, heart, skin and cancer diseases. Therefore, according to the reduction effects that bee venom had on the symptoms of neurological diseases including Parkinson's, we decided to review the studies done on the potential effects of bee venom on Parkinson's disease.

Parkinson's disease after Alzheimer's is the most common neurodegenerative disease. It is the second most commonly reported neurodegenerative disorder. To create an animal model of Parkinson's disease, the black dense component of rats in 6-hydroxy dopamine (6-OHDA) was unilaterally destroyed in a stereotactic device. After 3 weeks, in order to evaluate the degradation rate, intra-peritoneal rats were given apomorphine they received. The number of spins was counted for one hour after the injection. These rotations were the main parameter for diagnosis of Parkinson's disease in rats. After a month, they received probiotic treatment for one month. After this, once again, the apomorphine test was performed and the result was compared with the previous series. In the Parkinson's group who received probiotics, the number of spins from apomorphine injected significantly decreased compared with the Parkinson's group receiving probiotics (p≤0.001). In addition, Parkinson's group showed more rotation than the sham group. The results showed that, on the one hand, neurotoxin-6-hydroxy dopamine can cause Parkinson’s formation in rats, with dopamine agonist injections rotate. Probiotics, on the other hand, can reduce the number of rotations and play a role in improving it. One of the main causes of Parkinson's disease is the imbalance between free radicals and antioxidants. The use of probiotics increases the antioxidants and reduces free radicals. Many studies have shown the role of dopamine receptor agitation in neurological disorders such as Parkinson's. According to the results of this study, the probabilistic probability of Bacillus coagulance with increasing dopamine expression led to improvement of neurological disorders and treatment of Parkinson's disease in rats. The black body is the main source of dopamine secretion that plays an effective role in controlling voluntary movements and coordination in musculoskeletal conditions. Regarding the fact that in this study, 6 hydroxy-dopamine degrading regions of the brain reduced the concentration of dopamine and created Parkinson's. Probiotics may improve the disease through the concentration of dopamine in other centers of the central nervous system.

Parkinson's disease is the second most common neurodegenerative disorder after Alzheimer's disease and the most common cause of disability . it is a progressive disease that is associated with the destruction of nerve cells. Caloric restriction is the only preventive action that has a life long-lasting effect on laboratory models. It has been shown in a large scale of laboratory animals that caloric restriction increases life expectancy, decreases the incidence of several age-related diseases, and preserves youth activities. Therefore, the aim of this study was to investigate the effect of caloric restriction diet on reserpine-induced catalepsy in male rats model of Parkinson's disease.

In this study, 30 Wistar rats were divided in 5 groups (control, Parkinson's disease,caloric restriction, Parkinson's disease + caloric restriction, caloric restriction+ Parkinson's disease(2) ).Animals in caloric restriction groups were under the caloric restriction of 30 percent. Parkinson's disease was induced by administration of Reserpine (1 mg/kg, i.p). The bar- test was used to measure cataleptic symptoms.

catalepsy was significantly lower in of caloric restriction + Parkinson's disease and caloric restriction+ Parkinson's disease (2) groups than in Parkinson's disease group. (P <0/05).

caloric restriction of 30 percent can improve reserpine-induced catalepsy in male rats model of Parkinson's disease. Also, caloric restriction before inducing Parkinson's disease reduces the severity of complications after getting sick, including catalepsy.