جستجوی مقالات مرتبط با کلیدواژه "آبله میمون" در نشریات گروه "پزشکی"

Monkeypox is a self-limited disease with symptoms that disappear within 14 to 21 days. Clinical management of monkeypox includes general supportive care and the use of antivirals that have activity against the monkeypox virus. This literature study aims to describe the role of tecovirimat in the management of monkeypox. Tecovirimat is an antiviral drug approved by the U.S. Food and Drug Administration (FDA) as part of the treatment management of smallpox in adults and children. Evidence of the efficacy of tecovirimat as mpox therapy was obtained from animal studies, where tecovirimat reduced mortality rates, reduced duration of illness and viral shedding. Tecovirimat inhibits the vp37 viral protein encoded by the F13 gene of the variola virus. This protein is highly conserved in orthopoxviruses, allowing tecovirimat to have in vitro activity against several orthopoxviruses, including vaccinia, variola, cowpox, and monkeypox viruses. In conclusion, tecovirimat is used in monkeypox sufferers with severe clinical conditions (sepsis, encephalitis, extensive lesions, bleeding manifestations), patients at risk of experiencing severe clinical conditions (immunocompromised, pregnant or breastfeeding, history of psoriasis, varicella zoster infection) and patients with one or more complications.

Monkeypox (MPX) is an emerging zoonotic virus of the genus Orthopoxvirus that can occasionally be transmitted to humans. With globalization and high-speed spread around the world, MPX has distributed across continents, has risen to the top of the world concerns. In light of the COVID-19 pandemic, recent outbreaks of the virus have raised concerns about serious comorbidities, and risks to the fertility of those affected. The virus can be transmitted through contact with an infected animal, virus-contaminated surfaces, or an infected person through body fluids (including vertical transmission), wounds, respiratory droplets, respiratory secretions, skin lesions, or significantly through semen and vaginal fluid. Understanding the pathophysiology will help determine the mechanism of action of monkeypox virus. Many questions about monkeypox remain unanswered. A deeper understanding of these issues will help develop preventive and therapeutic approaches to viral infertility and sexually transmitted infections. But since contamination of semen with other viruses can have adverse effects on male fertility, until all aspects of the disease are known, it is recommended to take precautions during sexual activity to reduce the risk of contracting monkeypox.

The current monkeypox outbreak reawakens the concern that poxviridae have a high potential for zoonotic spillover and causing a pandemic. Much fieldwork and research have been done by health care and public health workers in Africa during previous human outbreaks, and their knowledge should inform our global response to the current outbreak. However, unusual clinical presentations now have potential implications for recognizing the disease. In addition, infections from poxviridae, such as monkeypox, have common cutaneous signs that occur early, may be related to periods of transmissibility, and can leave scarring. Therefore, dermatologists will play a key role in recognizing and diagnosing infections and educating and preparing frontline health care workers for the early detection of new cases and clusters of monkeypox.