جستجوی مقالات مرتبط با کلیدواژه "اوندانسترون" در نشریات گروه "پزشکی"

Nausea and vomiting is one of the most common complications after the strabismus surgery. In this study, we evaluated the efficacy of atropine versus ondansetron administration on the incidence of postoperative nausea and vomiting and duration of recovery stay in patients undergoing this procedure.

In this case-control study, 90 patients between 3 to 30 years old who were candidates for elective strabismus surgery in Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran, from February to April 2019, were randomly divided into three groups (placebo, ondansetron and atropine group). Patients who had taken hypnotic drugs while entering the operating room were excluded. In all patients, after arriving into the operating room and installation of standard monitoring equipment and peripheral vein implantation, anesthesia was induced by receiving 0.05 mg/kg midazolam, fentanyl 1 μg/kg and propofol 2.5 mg/kg. After induction of anesthesia, placebo group was compared with ondansetron group and atropine group that received 0.1 mg/kg ondansetron and 30 µg/kg atropine, respectively. The rate of postoperative nausea and vomiting, duration of recovery stay and satisfaction of recovery nurses were recorded and compared between groups.

There was no statistically significant difference between the three groups in terms of mean age, weight, and gender. It seems that group matching is appropriate and there are no confounding factors for demographic variables. Administration of atropine and ondansetron significantly reduces the incidence of nausea and vomiting postoperatively and in recovery. There was no significant difference in the incidence of nausea and vomiting between the atropine and ondansetron groups. Duration of recovery stay was decreased after ondansetron and atropine administration versus control group. Postoperative laryngospasm and bronchospasm were not observed in any of the three groups after surgery and at the time of recovery. The satisfaction of recovery nurses in both atropine and ondansetron groups were higher than control group.

It seems that the administration of atropine as much as ondansetron can be effective in reducing the incidence of postoperative nausea and vomiting and the length of recovery stay in patients who undergoing strabismus surgery.

Aims and Postoperative nausea and vomiting is a distressing situation with a prevalence of 10 - 30%. As dexamethasone and metoclopramide are inexpensive drugs and cause little complications, and ondasetron in turn is a good and high quality drug for relieving patients ftom nausea and vomiting, we compared the effect of dexamethasone and metoclopramide versus dexamethasone and ondasetron on nausea - vomiting and shivering in patients undergoing laparoscopic cholecystectomy, in the study.
The present study is a randomized, double - blind clinical trial. After obtaining consent from pations, study was performed on 88 patients allocated with sampling and blocking method. The first group received the combination of dexamethasone and ondasetron, and the second group received the combination of dexamethasone and metoclopramide. The anesthetist injecting drugs,was unaware of the type of injectable medicine. The anesthetic method and the drugs used for anesthesia were the same in both groups. After the operation, the questionair asked questions about nausea - vomiting and shivering for up to 24 hours (at intervals of 1 - 6 -12 and 24 hours), and all the answers were recorded for each participant. Finally all findings were analyzed statistically using spss version 20.
Findings: In this study 88 patients were divided into 2 groups. the first group received the combination of dexamethasone and ondasetron, and the second group received combination of dexamethasone and metoclopramide. the mean average age in the D group was 41.07 years and in the D group was 42.16 years. The result of this study showed that there was insignificant decrease in nausea and vomiting after laparoscopic cholecystectomy;also none of the patients in the study groups showed any shivering.
The result of this study showed that the combination of ondasetron and dexamethasone could not significantly reduce the incidance of post operative nausea and vomiting compared to combination of dexamethasone and metoclopramide. No patients in the study groups had shivering.

Postoperative nausea and vomiting (PONV) is frequent adverse event of anesthesia and surgery. Patients after middle ear surgeries are in greater risk of PONV. Likewise، this complication may destroy results of reconstruction and anatomical alignments. Numerous antiemetics have been studied for the prevention and treatment of PONV in patients scheduled for middle ear surgeries. This study aimed at comparing intravenous ondansetron and dexamethasone in this regard. In a double-blind randomized clinical trial، 219 candidates of middle ear surgery were randomized in three groups; O، D and P and studied in Tabriz Imam Reza Hospital. Patients in group O received ondansetron (4 mg، IV)، in group D received dexamethasone (8 mg، IV)، and in group P placebo prior to induction of anesthesia. Incidence of PONV، as well as its severity (according to Beilville scoring system) was documented during 24 hours after surgery and compared between the three groups. During 2-8 and 8-16 hours after operation، the incidence of PONV was significantly higher in group P (P<0. 001). Similar results were documented regarding the severity of PONV. Intravenous ondansetron and dexamethasone are both more effective than placebo in controlling the PONV after middle ear surgeries. Dexamethasone is significantly more effective than ondansetron in preventing the PONV.

Nausea and vomiting of pregnancy (NVP) are seen in 50-90% of pregnancies. Mild to moderate NVP in the first trimester of pregnancy in most patients can be cured by ensuring them. However, in severe cases medical therapy to reduce nausea and vomiting is inevitable. Ondansetron as a drug effective in reducing nausea and vomiting is one of the therapies for the treatment of NVP that recently has been proposed. This study compared the effectiveness of Ondansetron and Metoclopramide in the treatment of NVP In a clinical trial study 70 pregnant women with NVP were selected in Sahid Beheshti hospital in 2010 and randomly divided in 2 groups. The first group administered oral administration of Metoclopramide and the second group were treated by Ondansetron for 3 weeks. The daily frequency of nausea and vomiting and medication side effects were studied before starting the intervention and three days, a week, two weeks and three weeks after treatment in the two groups. Data analysis was done by χ2, Fisher exact test and Student t–test. The results showed that there was not a significant difference between groups on the trend of change of nausea during treatment (P = 0.27) but the number of vomiting in Ondansetron group was significantly lower than other group (P = 0.04). Ondansetron have more favorable effect in controlling NVP. If the patient accept and this drug is safe in pregnancy, it can be used to control NVP during pregnancy.