جستجوی مقالات مرتبط با کلیدواژه "بلوغ دیررس" در نشریات گروه "پزشکی"

Puberty is the period of developmental changes from childhood to adulthood and the acquisition of fertility. The time of puberty likely affects future risks such as cancer, metabolic syndrome and cardiovascular diseases. Many evidences point to the role of environmental exposure in changing the time of puberty. This review article was performed with aim to investigate the effect of lead on pubertytime in girls and boys based on the studies performed in this field.

In this review article, English and Persian articles related to observational studies which were indexed in databases of Embase, PubMed, Scopus, ISI Web of Science, SID, and Google Scholar during 2000-2018 with different combinations of the keywords of "lead” and "Puberty" were selected from Medical Subject Headings (MESH). From 182 reviewed articles, 12 articled related to the aim were selected based on inclusion and exclusion criteria and quality of reporting articles according to STROBEchecklist. 

12 articles were classified in two domains of lead effects on the puberty of girls and boys. The results of most studies showed that there was a statistically significant association between blood lead levels in girls, especially high levels, with delayed appearance of menarche, development of breast and growth of pubic hair. In boys, there was a statistically significant association between blood lead levels, especially high levels, with a delay in the process of puberty, including increased testicular mass and growth of pubic hair.

Lead can affect the natural process of puberty, and especially is effective in delaying puberty of girls and boys.

Puberty is a period between childhood and adulthood that the complex process by which children develop secondary sexual characteristics and complete with development of sexual and reproductive capability. This study was conducted to determine pattern of puberty in girls who lived in Ahvaz، Iran.

This cross sectional study was conducted on 1680 girls age 5-15 in Ahvaz، Iran in 2013. Participants were selected by random cluster sampling. Secondary sexual characteristic were evaluated clinically by inspection and palpation. Age of menarche was asked. Data were analyzed by SPSS software version 16 anddescriptive statistical tests.

The mean age of tanner 2 of breast development (B2) and tanner 2 of pubic hair growth (PH2) was 9. 52 and 9. 82، respectively. The mean age of menarche in 566 girls (33. 69%) was 11. 86. Of 1680 girls، 1619 (96. 4%) had normal puberty، 15 girls (6. 1%) precocious puberty and 2 girls (2. 1%) had delayed puberty.

According to the findings، the age of onset of puberty was lower in compare of studies which were done in Iran and the world. Present study can provide baseline data for analysis of time trends، as well as for international comparisons.