جستجوی مقالات مرتبط با کلیدواژه "بکلومتازون" در نشریات گروه "پزشکی"

Inhaled corticosteroid is the first line of treatment for asthma which has its own side effects. By contrast, Montelukast has fewer complications and is easier to use because of its tablet-like form. Hence, the present study aimed to compare the effectiveness of inhaled beclomethasone with and without oral Montelukast in the control of children’s persistent asthma.
This clinical trial study was performed on 84 children with asthma referring to Amirkola Children's Hospital in two groups. One group of patients received inhaled beclomethasone with Montelukast. The another group was treated with only inhaled beclomethasone alone. Before and 3 months after the treatment, FEV1, IgE, eosinophilia, night sleep quality, and school absenteeism status were measured in both groups.
FINDINGS: FEV1 values presented no significant difference between the two groups before the treatment, but it significantly increased in both groups three months after the treatment (p=0.000) (from 71.8±2.1 to 89.4±2.1 in the combinative treatment group and from 72±3 to 88.3±2.4 in the beclomethasone group). However, there was no significant difference between the two groups in this regard (p=0.146).
The results of this study showed that although the increase in FEV1 was similar in the two groups after treatment, but due to the better therapeutic acceptance in the combination therapy group, combination therapy could be used to control children's asthma.

Drug treatment of Allergic rhinitis is based on anti-histaminic and anti-inflammatory drugs. Glycyrrhizic acid is an effective ingredient of liquorice root that has affirmed anti-histaminic and anti-inflammatory natures. The present study has evaluated the clinical efficacy of local glycyrrhizinic acid drop for treatment or reduction of allergic rhinitis. A double blind clinical trial study was preceded on patients with allergic rhinitis that referred to the ENT clinic of Baghiyatallah hospital. The severity of rhinitis symptoms (rhino rhea, Sneeze, pruritus, congestion) were evaluated before and after treatment with either beclomethasone nasal spray (standard) or glycirrhizic acib nasal drop. Also, complications of treatments and rate of recovery were recorded. The rate of allergic rhinitis symptoms including, sever rhinorhea, Sneeze, pruritus and congestion were lowered significantly after consuming of either glycyrrhicinc acid or beclomethasone nasal spray on day 3. While, more reduction of moderate sneeze and congestion was seen prominently in patients who received beclomethasone, but patients with mild symptoms were increased in beclomethasone treated group. This study showed that efficacy of glycyrrhizinc acid nasal drop is closely similar and comparable to the beclomethasone nasal spray in treatment of severe symptoms of allergic rhinitis. So, this drug can be premier for treatment of severe allergic rhinitis, because of more accessibility and less complications than chemical drugs.

Inhaled corticosteroids are recognized as the most effective anti-inflammatory therapy in patient with asthma. Further studies must be done about potential adverse effects of inhaled corticosteroid on linear growth in asthmatic children. This study aims to assess the effects of treatment with Inhaled corticosteroids on linear growth in 6-12 years old asthmatic children. In a randomized clinical trial study, we randomly selected 70, 6-12 years old, asthmatic children as cases and 70 healthy children as control group. The asthmatic children were classified into two groups, one group included 35 asthmatic patients on beclomethasone 450 microgram per day and another group included 35 asthmatic patients on fluticasone 250 microgram per day. Height of all children was measured with standard stadiometery in first visit, six month and one year later. The data were analyzed using t, Chi- Square and analysis of variance tests. There were 106 boys (75.7%) and 34 girls (24.3%). mean age was 7.35±1.09 without any significant difference between three groups. There was no significant difference in sex and duration of ICSs consumption among the groups. Mean of height growth, 6 month after ICSs prescription was 3.26 cm in beclomethasone group, 2.9cm in fluticasone group and 3.01 cm in control group. Mean of height growth one year after ICSs prescription was 6.21 cm in beclomethasone, 6.07 cm in fluticasone group and 5.92 cm in control group. The differences were not statistically significant. We observed no significant negative effect of usage of Inhaled corticosteroids (Beclomethasone 450 microgram per day and fluticasone 250 microgram per day) for 3 to 6 months on linear growth of asthmatic children.

Statement of Problem: Candida is an opportunistic organism which will become pathogen if predisposing factors are present. One of the predisposing factors for increasing prevalence of candida is the use of corticosteroids. Researches on candida infections in treated patients with inhaled corticosteroids are controversial. The purpose of this study was evaluating the effect of two inhaler corticosteroids (Fluticasone and Beclomethasone) on the number and frequency of candida species in saliva and its comparison with normal subjects. This experimental research was performed on three groups of individuals. The first group was 30 asthmatic patients used inhaler Fluticasone, the second group with the same number of patients used inhaled Beclomethasone and the third group was composed of 60 normal individuals as control. Subjects were selected after evaluating the medical history and assurance of absence of the predisposing factors. Subjects’ saliva were gathered in sterilized tubes and cultured in chromagar media for evaluating the type of candida. The results were analyzed with oneway and tukey tests. Based on this study, the number of candida species was significantly different among the three groups. The number of candida species in patients used fluticusone was higher in comparison with the other two groups (p<0.001). This study showed that the number of candida species in patients treated with corticosteroids inhaler was high in comparison with the control group. Thus for avoiding candida infection, proper oral heath and prevention of predisposing factors in these patients are recommended.