جستجوی مقالات مرتبط با کلیدواژه « تترااتیل آمونیوم » در نشریات گروه « پزشکی »

Nuclease and caspase activities that promote death signals and cause apoptosis are dependent to potassium ion.
The aim of this study was to investigate the effect of potassium channel blocker tetraethylammonium (TEA) on prevention of Parkinson's disease in rats.
This experimental study was conducted on 33 male rats in Qazvin University of Medical Sciences, 2014. 6-hydroxydopamine (6-OHDA) was injected into the striatum of the brain. The rats received different doses of TEA twice daily the day before the 6-OHDA injection till 15 days after the injection. The severity of Parkinsonism was assessed by the apomorphine-induced rotational behavior, the elevated body swing test (EBST), and the rotarod test. Data were analyzed using Kruskal Wallis and Mann Whitney U tests.
Findings: Pretreatment with 5 mg/kg TEA significantly reduced the severity of rotations compared to the saline group. TEA did not reduce the swings in the EBST. In the rotarod test, TEA caused significant improvement in the motor performance of the rats.
With regards to the results, it seems that pretreatment with TEA can partly reduce the severity of behavioral symptoms in the 6-OHDA-induced chronic Parkinson's disease. The higher the TEA dose, the more significant the reduction in the severity of symptoms.

4-aminopyridine (4-AP) and tetraethylammonium (TEA) are two potassium channel blockers which have shown that have beneficial effects in treating some neurological disorders such as ataxia, Alzheimer and multiple sclerosis. In this study the effect of acute administration of 4-AP and TEA in the treatment of behavioral symptoms of Parkinsonism induced by the toxin 6-hydroxydopamine (6-OHDA) was studied in male rats. 6-OHDA was injected into left medial forebrain bundle (MFB) by stereotaxic surgery using Hamilton syringe. Then, in the third week after surgery, the rats before and after drug application were tested for rotational behavior induced by apomorphine. In the fourth week, Rotarod test was performed in the presence of the blockers for six consecutive days. 4-AP at doses 200 and 500 µg/kg had no significant effect, but at dose 1000 µg/kg led to a significant improvement of behavioral symptoms of Parkinsonism in the rotation test. On the other hand, the drug decreased motor performance and motor learning in the Rotarod test. TEA at dose 1 mg/kg was ineffective, but at dose 2 mg/kg caused a significant decrease, and at dose 5 mg/kg caused a significant increase in the number of rotations of the Parkinsonian rats. TEA had no effect on the motor learning in the Rotarod test. The results of this study indicate that 4-AP and TEA, in a dose-dependent manner, weaken some symptoms of Parkinsonism, but worsen some other symptoms.