جستجوی مقالات مرتبط با کلیدواژه « تری فلورالین » در نشریات گروه « پزشکی »

Trifluralin is a widely-used herbicide that inhibits proper cell proliferation in the root of plants. Therefore, the present study was conducted in order to investigate the effects of trifluralin on immune system of the NMRI mice challenged with sheep red blood cells(SRBCs). The study population consisted of 14 male NMRI mice randomly catagorized into two equal groups and then were immunized with SRBC. The mice in the treatment group received trifluralin (5omg/kg orally-0.01 LD50) per day from the beginning of the study,which continued for 2 weeks. The results of the current study indicated a significant decrease in the levels of anti-SRBC antibody and simultaneously a significant decrease in the delayed type of hypersensitivity(DTH) in the treatment group compared to the control group. Furthermore, the level of respiratory burst of phagocytic cells, the lymphocyte proliferation index of splenocytes, as well as the spleen weight index significantly decreased in the treatment group compared to the control group. The study findings revealed that trifluralin even in the low dose may lead to a significant suppression in regard with many aspects of the immune system.

Trifluralin is a dinitroaniline herbicide and is used for controlling of annual grasses and broadleaf weeds in agriculture. It enters into the plants through developing roots and stops plant cells from dividing and elongation (meristemic inhibitor). According to entrance of this herbicide into the body via fresh vegetables, in this research the effects of trifluralin on reproductive parameters of the male wistar rats including serum LH, FSH, testosterone, and changes in testicular tissue and body weight were investigated. In this experimental study, forty male wistar rats with weight of 250±5g were randomly divided in 5 groups, including control, sham (received normal saline as a solvent), and three experimental groups receiving 500, 1000 and 2000 mg/kg oral trifluralin, respectively. It was administered orally once a day for 16 days. After 16 days, body and testis weight were measured and blood samples were taken from heart and used for measurement of LH, FSH and testosterone levels. To evaluate histological changes, testes were removed and weighed and, after obtaining tissue section, stained by Hematoxilin-Eosine. Serum testosterone, FSH, and LH levels showed significant decrease in experimental groups (p<0.001, p<0.05). There was significant decrease in the number of germinal and somatic cells in testis in experimental groups (p<0.05). There was also a significant decrease in body and testis weight, and concentration of sperms in experimental groups (p<0.05). Oral administration of trifluralin could decrease gonadotropins and testosterone levels and impair steroidogenesis and spermatogenesis by oxidative stress and production of free radicals.