جستجوی مقالات مرتبط با کلیدواژه "تومور تخمدان" در نشریات گروه "پزشکی"

Ovarian serous cystadenofibroma is an uncommon tumor in pregnancy. In this study, a pregnant woman with asymptomatic giant ovarian serous cystadenofibroma who underwent successful surgery was introduced.

The patient was a nulliparous 31-year-old woman (14 weeks), asymptomatic that a multilocular cyst with dimensions of 259×173 mm originating from the right ovary was reported in the routine pregnancy ultrasound. The levels of CA-125, CA 19-9 and HE4 were 72, 8.5 and 27.3 U/mL, respectively, and the Roma index was 2.7 U/mL. The patient underwent open abdominal surgery and after being sent to pathology, the diagnosis of ovarian serous cystadenofibroma was confirmed. Finally, the patient underwent caesarean section at 39 weeks and two days of gestation due to macrosomia and a full-term baby weighing 4300 gr was born.

In pregnant women with ovarian serous cystadenofibroma, mass surgery, considering the tumor size and the levels of tumor markers such as CA-125 can be an effective treatment with minimal complications, especially in young nulliparous women who are interested in preserving the uterus.

Sclerosing stromal tumor (SST) is a rare tumor of sex cord stromal tumor. Regarding to specific clinical, historical and hormonal feature, it has been differentiated from sex cord stromal tumor. In this study, a rare case of ovary sclerosing stromal tumor is reported.

A 37-years-old woman with history of one pregnancy, one normal delivery and 3 months amenorrhea referred to physician and was evaluated. Sonography showed a solid cystic mass in right adnexa, intraperitoneal free fluid and normal tumor marker, and was admitted in Emam khomeini hospital, Tehran university of medical sciences with possible diagnosis of malignancy and underwent open surgery. The mass was released from the tissue around the ovary and was sent to frozen section pathology. She underwent right salpingo oophorectomy according to the possibility of stromal sclerosing tumor.

Solid masses with intraperitoneal free fluid are considered as the cases of differential diagnosis of ovary malignant tumor, but some benign tumors such as SST could present with malignant feature in sonographic pattern, it is suggested to do limited surgery with preserving ovary before excessive surgery and sending the sample to frozen section and pathology confirming of benign tumor based on ovary sclerosing stromal tumor.

Ovarian sex cord-stromal tumors (SCST) account for rare ovarian malignancy. These tumors are 5-8% of all ovarian neoplasms. The most common type of sex cord ovarian tumors is granulosa cell tumor (GCT). In this study our purpose was to have a look at some of clinicopathologic aspects and treatment results of these tumors. In a retrospective study, all documents of patients with SCST was referred to tumor clinics of Ghaem and Omid Hospitals, from 1998 to 2008. The data of patients were collected and analyzed. In 39 (5.9) of the 398 cases, ovarian malignancies was present in SCST. Eight Patients omitted from the study because there were not enough data for them. The commonest pathology was adult granulosa cell tumor in 25 patients (80.6%). Two patients (8.33%) had juvenile granulosa cell tumor, they were 25 and 38 years old. At time of diagnosis, 27 cases (87.1%) were in early stages (stage I). Mean age of patients was 41 years (range 16-76 years) at time of diagnosis of disease. Surgical staging of cancer was performed in 14 patients (46.7%). We did fertility sparing surgery in 12 patients (40%). Two patients were pregnant after surgery. 17 patients (54.80%) did not receive chemotherapy. Three patients (9.7%) received radiotherapy. Overall survival rates were 95% at both 2 years and 5 years. Longer survival had correlation with early stages of disease (P= 0.002). Age, conservative surgery and chemotherapy had no correlations with survival. The prognosis of SCST is almost good. Most of the patients were diagnosed in early stage of disease. In sex cord ovarian tumor, the only factor that have a full effect on survival, is stage of the disease. If the patients desire to preserve fertility, we can do fertility sparing surgery with minimal effect on survival.

Ovarian mucinous borderline tumors are divided into two morphologic groups: endocervical-like and intestinal type. Most endocervical adenocarcinomas exhibit mucinous and/or endometrioid differentiation، they infrequently metastasize to the ovaries but may simulate primary ovarian tumors (both atypical proliferative or borderline and carcinoma). In patients with mucinous adenocarcinoma in the abdominal cavity، caution should be exercised in interpreting the possible primary site of the tumor on the basis of the immunohistochemical profiles. The presence of human papillomavirus (HPV) DNA is assessed to determine whether the ovarian neoplasms were metastases or primary independent neoplasm. Approximately 90% of endocervical adenocarcinomas are related to high-risk human papillomavirus (hr-HPV) with the remainder being unrelated to HPV. Both types metastasize to the ovaries very infrequently. Ovarian endocervical-type (mullerian) mucinous tumors and tumors composed of a mixture of endocervical-type mucinous، serous endometrioid، squamous، and indifferent cells with abundant eosinophilic cytoplasm reported to date have been primarily limited to borderline and micro invasive types. We report a-36-yr old woman with adenocarcinomas of uterine cervix who also had ovarian mucinous borderline tumor. The patient presented with abnormal uterine bleeding and lower abdominal pain. She had a history of uterine cervix polyps. Pelvic ultrasound showed a right adnexal mass and a large cervical size. Histological diagnosis in uterine cervix biopsy revealed adenocarcinoma of cervix. Radical hysterectomy type III with bilateral salpingo-oophorectomy was performed. Histological finding in adnexal mass revealed borderline mucinous tissue of ovarian tumor. Testing for HPV DNA in the tumoral tissue was negative. This confirms that the ovarian tumor is not metastatic from endocervical adenocarcinoma. We conclude that in a patient with tumors that involve two organs، complete diagnostic investigation should be done to distinguish the primary origin. The factors that affect cell proliferation، can probably have synchronous effects on the two similar cells.

This article reports the cliniopathologic findings of an unusual case of granulosa cell tumor with androgenic manifestations in a 16-year-old girl. The patient presented with a 2-year history of amenorrhea. Physical examination revealed an increase in facial, chest and abdominal hair with breast atrophy and horseness of voice. Pelvic ultrasound demonstrated a 87x85x66mm left adnexal cyst. Plasma testosterone and 17-hydroxy progesterone levels were elevated. She underwent an exploratory laparotomy in which a left ovarian tumor, 8cm in diameter was found and extracted. Microscopic examination of the tumor revealed the typical features of a granulosa cell tumor of the ovary. Two months after surgery, plasma testosterone and 17-hydroxy progesterone levels were within the normal range and the patient had a regular menstrual cycle. To our knowledge, this represents the first case of a granulosa cell tumor with androgenic manifestations reported in Iranian literature.