جستجوی مقالات مرتبط با کلیدواژه « تومورهای نورواندوکرین » در نشریات گروه « پزشکی »

Neuroendocrine tumors (NETs) originate from peptide and amine producing cells of neuroendocrine system. Data presented in pathology reports, determine the prognosis and therapeutic approach of patients. The aim of this study was to investigate that how these indicators are reported in Shahid Sadoughi Hoaspital.

In this cross-sectional and descriptive study, all neuroendocrine tumors reported by pathology department of Shahid Sadoughi Hospital, were studied by census method from 2011 to 2015. Finally, 73 cases were studied regarding pathologic standard indices including pathology diagnosis, anatomic origin of the tumor, amount of mitosis, immunohistochemical staining, immunohistochemical staining type, determination of Ki67 index, the status of necrosis, vascular and perineural invasion.

Among 73 investigated pathology reports, small cell carcinoma was the most common pathologic diagnosis with 46.6% of cases. The most common anatomic site was respiratory system with 49.3% of cases. Amount of mitosis, Ki67 index, the status of necrosis and vascular, perineural invasion were mentioned in 31.5%, 28.8%, 34.2% and 15.1% of pathology reports respectively.

According to the results, most pathologic reports of neuroendocrine tumors lack one or more factors that is necessary for reporting. However, these factors are pivotal for determination of prognosis and therapeutic approach in patients.

Background and Incidence of neuroendocrine tumors in the world is increasing during these years. These tumors have a high complexity in clinical presentation, tumor stage and grade. In addition, using of markers like Ki67 level could help to estimate tumor grade. Assessing hospital prevalence of neuroendocrine tumors, Their origin and association between pathology and immunohistochemistry with Ki67 level was the purpose of conducting this study. All patients’ records during 2004-2010 were reviewed to select patients with neuroendocrine diagnosis, then their pathology and histochemistry samples were examined again. Patients’ characteristics in addition to type, grade and origin of tumors were entered to check list. Incidence of neuroendocrine tumors was 8 in 1000 patients. Data was gathered from 189 patients with neuroendocrine tumor diagnosis. Mean age was 49/6 years and Prevalence of each sex was 52/9% and 47/1% in men and women respectively. Pathology diagnoses were Carcinoid (27%), Round cell tumor (21.2%) and undifferentiated carcinoma (18.5%). Mean of Ki67 levels were significantly different by tumor grade, location, necrosis, pathology and immunohistochemistry. Based on this study, using Ki67 marker is helpful for diagnosing and determining tumor status, which could be effective on choosing the type of treatment.