جستجوی مقالات مرتبط با کلیدواژه « حرکات ارتودنتیک دندانی » در نشریات گروه « پزشکی »

IL-6 and IL-8 have an important role in orthodontic tooth movement and creation of periodontal diseases. Laser therapy in orthodontics has effect on decrease pain and increase regeneration of bone, acceleration of tooth movement and decrease inflammation in periodontoal tissues. The aim of this study, determination the effect of low laser therapy on GCF level of IL-6 and IL-8 during orthodontics treatments.
In this clinical trial study, we chose 10 patients with crowding or protrusion, that they need fix orthodontic treatment with extract of two premolars in each side and then retract the anterior teeth. After complete SRP, the orthodontic treatments started. After clinical examination such as CAL, PD and BOP the teeth in one quadrant selected case groups and the other quadrant selected control groups. Low Level laser irradiation done in 0,2,7, 21 days and collection of GCF is done in 2,4,9, 23 days with paper cone in distal sulcus of canine for 30 second. Then all of the samples transferred to laboratory and then t-test ANOVA and LSD test done.
The average of changes in IL-6 and IL-8 in GCF at the 21 day after laser irradiation had a significant difference but in the other days we didn’t have a significant difference.
Low level laser therapy at orthodontics treatment causes of decrease the inflammation and decrease the IL-6 and IL-8.

The product of RANKL gene expression has a fundamental role in bone resorption and activates the chain of osteoclast differentiation from its predecessor cells. Reports of this gene participation and role in physiologic and pathologic bone resorption led to hypothesis that it may play a role in bone resorption induced by orthodontic tooth movement. A closed coil spring (Dentaurum Ispringen, Germany) was fixed by two pieces of ligature wires to mesial side of the maxillary right first molar and anteriorly to both incisors of fifteen 7 week old Wistar male rats to tip the first molars mesially. The maxillary left first molar of each animal used as an internal control group for the contralateral tooth. The animals were sacrificed on the 21st day of the experiment and the tissue from the mesial side of maxillary molars was used for PCR test. Wilcoxon Sign Rank test was used for densitometric analysis of RANKL mRNA on the electrophoresis gel. Statistical analysis showed a significant increase in expression of gene in the experimental group compared to the control one (P<0.002). Genuineness of the PCR tests was verified by household gene of GAPDH. Based on the data obtained in controlled environment of the study, RANKL expression increased significantly following bone resorption induced by orthodontic tooth movement.

OPN gene has been shown to play an important role during bone resorption. The significant expression role of OPN gene in bone resorption hypothesizes the increased quantity of this glycoprotein during bone resorption induced by orthodontic tooth movement. The aim of this study was to assess the expression of OPN gene in rat bone resorption induced by orthodontic tooth movement. In an experimental study, fixed Ni-Ti closed coil springs were applied for mesial movement of the maxillary left first molars in 13 male 8-week-old Wistar rats. The animal's right maxillary first molars were used as internal controls of the study. The rats were sacrificed 21 days after application of orthodontic appliances. The scratched materials from mesial sides of the alveolar bone were used for PCR evaluation. The collected data were subjected to Wilcoxon Signed Rank Test. Densitometry analysis of OPN coding mRNA on electrophoresis gel exhibited significant increase in gene expression on resorptive (mesial) side of the alveolar bone (P<0.001). The authenticity of PCR assessments was verified by GAPDH gene. Based on the results of this investigation and considering the study limitations, OPN gene expression increases during bone resorption induced by orthodontic tooth movements.