جستجوی مقالات مرتبط با کلیدواژه "دنچر استوماتیت" در نشریات گروه "پزشکی"

Denture stomatitis is a chronic infectious lesion caused by Candida albicans along with other oral microflora in patients wearing dentures. A substance with fewer side effects should be established for the treatment of this lesion since it may lead to secondary complications for the patient. The present study was conducted by selecting and dividing 31 patients with denture stomatitis into case and control groups. Propolis mouthwash and Placebo were prescribed in the case and control groups, respectively. The participants were evaluated according to the severity of the lesions based on the clinical examination which was recorded in the datasheet by the examiner on the first, fifth, and tenth days after the start of the study. The results were statistically analyzed by SPSS software (version 24.0) using Shapiro-Wilk, Fisher’s Exact, One-Way ANOVA, Kruskal-Wallis, Friedman, and Bonferroni tests. A P-value less than 0.05 is statistically significant. The two groups were homogeneous in terms of age (P=0.282), gender (P=0.890), and denture stomatitis severity (P=0.203) at the beginning of the study. However, the improvement of denture stomatitis in the case group was significant compared to that of the control group after 5 days (P=0.014) and 10 days (P<0.001). The results displayed that the severity of the lesions significantly reduced in patients who received Propolis mouthwash. Consequently, Propolis simultaneously offers antibacterial, antifungal, antiviral, and anti-inflammatory properties, and it relieves denture stomatitis without any side effects. Therefore, it can be recommended to physicians as a routine medication.

Denture stomatitis is the most prevalent oral mucosal lesion among denture wearers. Because there have been multiple reports of resistance of Candida species to antifungal drugs in the last two decades, if the antifungal properties of Achillea millefolium and Trachyspermum ammi are validated, these compounds may be a suitable adjuvant drug along with the use of common antifungal drugs. Therefore, the current study aimed to assess the antifungal activity of alcoholic extracts of Achillea millefolium and Trachyspermum ammi against Candida albicans isolated from denture stomatitis.

Antifungal sensitivity of 50 isolates of C. albicans with the origin of denture stomatitis to the alcoholic extracts of Achillea millefolium and Trachyspermum ammi plants as well as the antifungal drugs miconazole and nystatin was determined by broth microdilution method and according to CLSI-M27S4 guidelines. The range of dilution for all compounds was 0.016-16 μg/ml. A concentration of compounds that showed at least 50% growth inhibition as compared to the positive control group was considered MIC (minimum growth inhibitory concentration). Statistical analysis was done using SPSS software and the significance level was considered as P<0.05.

The MIC ranges in microbroth dilution method for the antifungal drugs miconazole, nystatin, as well as the alcoholic extracts of Achillea millefolium and Trachyspermum ammi plants on C. albicans, were close to each other, indicating that their effectiveness against C. albicans species does not differ significantly (P<0.05). The Achillea millefolium methanolic extract had the highest and lowest MIC values, with an average of 2.67±2.55 μg/ml and 0.067±0.057 μg/ml, respectively. A significant difference (P<0.001) was observed when the MICs outcomes the herbal alcoholic extracts and antifungal drugs were compared.

Based on the obtained MICs, Achillea millefolium and Trachyspermum ammi alcoholic plant extracts have a lesser efficacy than the antifungal drugs, but even though they may have a lower MIC and more effectiveness than other chemical drugs.

With the increase of elderly population nowadays, the prevalence of denture stomatitis has increased, the etiology of which is Candida albicans .Due to the effectiveness of antifungal drugs to treat this disease. The purpose of this study was Evaluation of antifungal effect of denture adhesive after combination with three separate substances, chlorhexidine, nystatin and chamomile extract, against Candida albicans  .

This experimental study was performed on candida albicans (in vitro) in microbiology laboratory, faculty of Dentistry, Islamic Azad University of shiraz in 2019-20. The standard species of Candida albicans was inoculated in Sabord dextrose agar medium and incubated at 37 ° C. The denture adhesive was prepared according to the factory instructions and entered in standard antibiogram size molds and 50 microliters of chlorhexidine, Matrica and nystatin mouthwashes were combined with the denture adhesive, respectively. The combined materials were added to Candida albicans medium by disc diffusion and well method and the plates were incubated for 24 hours. Finally, the diameter of the stunting halo was measured in millimeters to test the research hypotheses of Kruskal-Wallis nonparametric tests (mean of several independent groups), Mann-Whitney (mean of two independent groups) and single-group mean, at the level of 0/05 significance used.

All compounds acted significantly differently compared to their raw state (P <0.05). The matrica-denture adhesive combination (10.66 mm) was better than the matrica alone (9.61mm) and nystatin(25.94mm) was more effective than the nystatin-denture adhesive(23.33mm). Chlorhexidine was also more effective than the combination with denture adhesive. Comparison of mean rank values shows that the combination of denture adhesive and nystatin is significantly more effective than other compounds and the effectiveness of chlorhexidine-denture adhesive and matrica-denture adhesive is not significantly different from each other (P> 0 / 05).

The combination of all three mouthwashes with denture adhesive has anti-candida effects, among which the combination of nystatin with denture adhesive has the strongest effect, secondarily the combination of chlorhexidine and denture adhesive, and finally the matrica composition.

This study aimed to evaluate the antibacterial and antifungal effect of Ag and zinc oxide nanoparticles to complete denture acrylic resin .

In this experimental laboratory study, 144 samples were evaluated. The powder of acrylic resin (PMMA Ivoclar Vivadent, Lichenstein SR Triplex Hot) was mixed homogeneously in the ultrasonic apparatus with Ag (purity: 99.99%, size: 20nm, spherical) and ZnO (purity: 99%, size: 10-30 nm, nearly spherical) particles with mass fraction 0.5, 1, 2 and 5. The microorganisms of this study were Candida albicans and Streptococcus mutans. The growth rate of microorganisms was measured by spectrophotometer based on turbidity and readings at 600 nm. Data were analyzed by SPSS 20 software. ANOVA and Tukey post hoc tests were performed. The significance level was set at 0.05.

increasing Ag and ZnO nanoparticles to acrylic resin reduced the growth of Candida Albicans and Streptococcus mutans. Even the concentration of 0.5% significantly reduced the growth of microorganisms. Complete growth inhibition was in the concentration of 5% after 24 and 48 hours.

Increasing the Ag and ZnO nanoparticles to acrylic resin reduced the growth of microorganisms.

Candidiasis is the most common fungal infection in oral cavity, usually caused by Candida albicans. Since one of the most common complications of denture wearing is denture stomatitis, presence of opportunistic microorganisms such as C. albicans and colonization of denture base by these microorganisms, the aim of this study was to compare the effects of three different methods of acrylic resin processing on adherence and colonization of C. albicans. In this experimental study, 60 square acrylic resin samples, measuring 10×10×10 mm3 (Ivoclar Vivadent, Liechtenstein) were processed with three methods of preparation: cold-cured [CC], heat-cured [HC] and injection-molded [IM]. Yeast suspensions were incubated on the surface of resin blocks for 40 minutes and then washed with 1 mL of sterile saline solution; 20 µL of this solution were inoculated on Sabouraud dextrose agar and incubated at 37 C. The colony counts were determined after 24 and 48 hours. At 60- and 120-minute intervals the colony counts were determined again. Data were analyzed with SPSS 20, using two-way ANOVA and paired t-test (α = 0.05). The method of preparation of acrylic resin (p value = 0.001) and duration of proximity of acrylic resin with the yeasts (p value < 0.001) were significant. The lowest colony counts were observed in the cold-cured method. In all these three methods and durations of proximity of acrylic resin and C. albicans, the colony counts at 48 hours were significantly higher than those at 24 hours (p value < 0.001). The acrylic resin preparation method affected the adhesion and colonization of C. albicans. Considering the lower colonization in cold-cured acrylic resin, it is the most appropriate acrylic resin, especially for those with poor oral hygiene or those susceptible to fungal infections.

The formation of dental plaques is one of the underlying causes of denture-related stomatitis. This study was conducted to evaluate the effect of the concentration of ozonated water on the inhibition of the formation of Candida albicans plaque on the acrylic resin pieces.
In this study, 45 resin acrylic plates were contaminated by Candida albicans suspension, which were randomly divided into nine groups. They were treated with 0.2, 0.5, 1, and 2 µg/ml of ozonated water, 25 and 12.5 µg/ml of ozonized oil, 100,000 units of nystatin (positive control), distilled water, and olive oil (negative control). Thereafter, the solution obtained from rinsing the pieces was cultured in Sabouraud Dextrose Agar and the mean number of the colonies was Mann-Whitney U and kruskal-wallis tests were for statistical analysis.
The mean number of the colonies obtained at the concentrations of 0.2, 0.5, 1, and 2 μg/ml of ozonated water was 24, 24.6, 23.6, and 14.4 colonies, respectively. Additionally, the mean number of the colonies obtained at the concentrations of 12.5 and 25 μg/ml of ozonized oil was 0 and 2 colonies, respectively. There was a significant difference between the solutions cultured in distilled water (146.6) and olive oil (98.8) in terms of the number of colonies (P Appropriate concentrations of ozonated water had an antifungal effect on Candida albicans. Therefore, further clinical studies are recommended to standardize and elaborate the guidelines for using ozone therapy.

The aim of this study was to investigate the effects of sodium bicarbonate against candida albicans, the main infectious factor of denture stomatitis, and to compare it with other common anti-candida medications.
Three concentrations of Candida albicans (105, 106, 107 CFU/mL) were prepared. Experimental substances were 5% sodium bicarbonate, nystatin, chlorhexidine, and sterile saline (as control). Each of them was added separately to the same amounts of Candida albicans of different concentrations, and sampled at the intervals of 1, 2, 3 and 4 min. Then, the samples were cultured and incubated. The number of formed colonies was counted for each plate. The data were analyzed, using ANOVA and Tukey test.
Sodium bicarbonate showed a noticeable anti-candida effect on the concentrations of 105 and 106 CFU/mL, with almost similar anti-candida effect as nystatin and chlorehexidine(P=0.29, P=0.32). Nystatin was the most effective medication on the concentration of 107 CFU/mL of candida (P=0.03, P=0.01). Sodium bicarbonate and chlorhexidine were less effective in this concentration with no statistically significant difference (P=1.00).
Sodium bicarbonate showed a significant anti-candida effect at low and medium concentrations of Candida albicans, but nystatin was more effective in the higher concentrations.

Statement of Problem:The surface topography of denture base material is an important factor for the adhesion of Candida albicans and other microorganisms. The aim of this study was to evaluate the adherence of Candida albicans to four types of denture base materials (Acropars acrylic resin, Meliodent acrylic resin, rough and smooth surfaces of Molloplast B). Seven blocks of two types of acrylic resins and ten blocks of silicone with one rough and one smooth surface were made and incubated in a suspension of Candida albicans. After washing,the blocks were stained with acridine orange and examined under fluorescent microscope. For statistical analysis ANOVA and Duncan tests were used. It was observed that Candida adhesion to rough surfaces of acrylic resins and silicone was significantly more than polished surfaces of acrylic resins and smooth silicone (PO.0001). However, no statistical significant difference was found between polished acrylic resins surfaces and smooth silicone. Significant differences in the adherence of Candida to the surfaces of different denture base materials are due to differences in surface topography, chemical, physical and hydrophobic properties so it is recommended to minimize the roughness and irregularities of denture base.