جستجوی مقالات مرتبط با کلیدواژه « رفلاکس معدی » در نشریات گروه « پزشکی »

Obesity is among the factors that are linked with gastroesophageal reflux disease (GERD). However, findings of previous studies on the relationship between obesity and GERD were conflicting. We aimed to assess the relationship between obesity and GERD in a large group of Iranian adults.
This cross-sectional study was performed on 4457 adults. Anthropometric measures were obtained by the use a validated self-reported questionnaire. Subjects were classified into three categories based on their body mass index (BMI): normal weight, overweight and obese. Also they were classified into three categories based on their waist circumference: normal, abdominally overweight and abdominally obese. The prevalence of gastrointestinal reflux disease was assessed according to Rome III criteria. Additional information about other variables was obtained using a self-administered questionnaire.
Findings: The prevalence of GERD among study population was 23.9%. In crude model, the obese individuals had a 58% greater chance for GERD [odds ratio (OR) = 1.58, 95% confidence interval (CI): 1.25-1.98), compared to those with normal weight. However, after adjustment for dietary habits and waist circumference, this association disappeared (OR = 1.06, 95%CI: 0.75-1.48). After adjustment for confounders, those with abdominal obesity had a 43% greater odd for GERD (OR = 1.43, 95%CI: 1.13-1.85). However further adjustment for weight interaction lead to a non-significance association (OR = 1.26, 95%CI: 0.96-1.65). Stratified analysis by gender revealed no significant association between obesity and GERG in men. But obese women had 43% increased odds of GERD and abdominally obese women had 51% higher odds of GERD; although adjustment for the mutual effects of waist circumference and weight disappeared these relations. There was no significant association between general or abdominal obesity and frequency or severity of GERD, after adjustment for all potential confounders.
General obesity was significantly associated with increased risk of GERD; however, this association disappeared after controlling for dietary habits and waist circumference. Abdominally obese individuals had higher odds of GERD, compared to those with normal waist circumference.

Allergic rhinitis is the most common type of allergic disease among population. Its accurate treatment is very important for cutting of allergic march. On the other hand, gasteroesophageal reflux disease (GERD) is one of the most common gastrointestinal problems among allergic patients mainly asthmatic cases. It might conflict treatment. Despite of asthma, a few studies have been conducted on the impact of GERD treatment on allergic rhinitis symptoms. In this study, we assessed GERD treatment and its effects on improving of allergic rhinitis patients with GERD. In a prospective cross-sectional study, March - September 2012, 103 consecutive patients with persistent moderate to severe seasonal allergic rhinitis enrolled. For allergic rhinitis patients with GERD 20 mg omeperazole once daily for 6 weeks prescribed, empirically. Conventional allergy treatment continued and finally the allergic rhinitis symptoms were assessed clinically and recorded before, 5th, 10th and 30th days of omeprazole treatment period. Our study included 103 patients with seasonal allergic rhinitis who were divided into GERD (n=33, 38%) and non-GERD (n=70, 68%) groups with the mean age 28 and 25.7 years, respectively. The first group developed significant improvement for GERD symptoms on days 5, 10 and 30 after beginning of therapy (P=0.03). No association was found between GERD treatment and relief of allergic symptoms or TNSS improvement (P>0.05). Data analyzed by Epi info (ver 7) and SPSS software (ver 11.5), and by Chi squeare test and paired T test. P lower than 0.05 was considered as significant. This study showed no significant association between empirical treatment of GERD and improvement of allergic symptoms in patients with allergic rhinitis. However, further studies with a larger sample size might be needed.