جستجوی مقالات مرتبط با کلیدواژه "زخم دهانی" در نشریات گروه "پزشکی"

Aphthous and oral ulcers are the most common ulcerative conditions of the oral mucosa, presenting as painful sores on the oral or tongue mucous membranes that make eating and drinking difficult. Zataria multiflora Boiss. has demonstrated therapeutic potential and has been used in formulations such as Protact® mouthwash. Recent studies indicate that this plant possesses several therapeutic effects, including alleviating inflammation and promoting healing in oral, digestive, and skin wounds. Given the documented effectiveness of this plant in treating various types of oral wounds and inflammation, along with the availability of Protact® mouthwash in pharmacies nationwide, this study aims to evaluate patient and physician satisfaction with the efficacy of Protact® mouthwash for treating oral ulcers and aphthous ulcers in Sari and Babol, the two largest cities by population in Mazandaran province.

This descriptive, cross-sectional study included a sample of 75 individuals, consisting of 35 physicians and 40 patients from Sari and Babol who either prescribed or used Protact® mouthwash. A convenience sampling method was used, with participants selected based on their willingness to complete a checklist. Data were collected by trained interviewers visiting medical centers, physician clinics, and pharmacies, and inviting participants to complete the checklist. Data were presented as mean ± standard deviation (M ± SD), percentages, median, minimum, and maximum values. Statistical analysis was performed using chi-squared, Kolmogorov–Smirnov, and independent t-tests.

The majority of participants in both groups were men (patients: 52.5%, or 21 out of 40; physicians: 94.3%, or 33 out of 35). The mean, median, standard deviation, minimum, and maximum ages for physicians were 53.94, 56, 7.6, 40, and 68 years, respectively, while those for patients were 40.13, 42, 10.8, 18, and 63 years, respectively. Most patients in this study (75%) reported a high level of satisfaction after using Protact® mouthwash. This mouthwash was mainly used for the treatment of aphthous stomatitis and oral inflammation, with a frequency of 52.5%. Results from the physicians' checklists showed that Protact® mouthwash was most frequently prescribed by dentists (42.9%), followed by general practitioners, hematologists and oncologists, and radiologists (each with a frequency of 11.4%). Additionally, physicians expressed satisfaction with the healing progress in their patients.

The findings support the effectiveness of Protact® mouthwash, a natural product produced in Iran, for the prevention and treatment of oral cavity-related conditions. The efficacy of this product is likely attributed to the presence of major phytochemicals in Zataria multiflora extract and essential oil, including thymol and carvacrol, which possess anti-inflammatory, antioxidant, antimicrobial, and tissue-regenerative properties beneficial to mucosal and skin healing.

Oral cavity is the entrance gate of respiratory and gastrointestinal tract. Therefore, oral health could be as mirror of global health. Timely diagnosis & early treatment of oral lesions, especially in susceptible admitted patients in infectious disease department have a vital role in health policy. Therefore, this study was designed to assess the frequency of oral soft tissue lesions in patients admitted to the Infectious department of Yazd Shahid Sadoughi of Medical Sciences.

This cross-sectional study was carried from January 2018 to March 2018. Eighty-nine who were admitted to the department of infectious diseases were eligible to participate. Clinical data regarding age, sex, type & site of lesions, oral hygiene status, smoking, and dental prostheses were documented. Data were analyzed by SPSS 19 using Chi-square and Fisher exact tests. The significance level was set at 0.05 with a 95% confidence interval.

49 men and 40 women with the age of 53.4± 14.3 years were examined. The frequency of oral lesions in hospitalized patients in the department of infectious diseases reported 30%. Red-white lesions (57.78%) and vesiculo-bullose lesions (40%) were the most frequent lesions, respectively. Among studied variables, frequency of oral soft tissue lesions based on age (P=0.001), smoking (P=0.034) and oral health status ((P=0.042) had a meaningful difference.

This rate of frequency due to known side effects is a matter of concern and it is considered by experts

Since oral ulcers impair normal oral function of the individual, finding ways to accelerate the process of wound healing is necessary. Chamomilla recutita (CR) is an herbal plant that has beneficial effects on healing wounds. This study was conducted to compare the effect of CR mouthwash with 0.2% chlorhexidine on linear oral ulcer healing in rats. For this experimental study, 24 male rats were selected and general anesthesia was done. Then the linear ulcers were made in the central region of the tongue, at a depth of 1 mm and limited to the mucosa. The animals were randomly divided into two groups: control (chlorhexidine mouthwash) and target (CR mouthwash). Each group was randomly divided into three subgroups, and the animals were sacrificed on days 3, 7 and 10. Subjects were then sampled from the lingual region and examined by the pathologist in terms of the extent of granulation tissue, angiogenesis, mean number of fibroblasts, neutrophils, lymphocytes and macrophages, and the results were recorded. Data were analyzed by Mann-Whitney test. Both mouthwashes acted to the same extent to accelerate the repair process. And except for the percentage of macrophages on the third day (p= 0.028), other variables did not show any significant difference. Due to the similar effects of CR and Chlorhexidine 2% on oral wound healing and less side effects of the herbal mouthwashes, CR mouthwash Since oral ulcers impair normal oral function of the individual, finding ways to accelerate the process of wound healing is necessary. Chamomilla recutita (CR) is an herbal plant that has beneficial effects on healing wounds. This study was conducted to compare the effect of CR mouthwash with 0.2% chlorhexidine on linear oral ulcer healing in rats. For this experimental study, 24 male rats were selected and general anesthesia was done. Then the linear ulcers were made in the central region of the tongue, at a depth of 1 mm and limited to the mucosa. The animals were randomly divided into two groups: control (chlorhexidine mouthwash) and target (CR mouthwash). Each group was randomly divided into three subgroups, and the animals were sacrificed on days 3, 7 and 10. Subjects were then sampled from the lingual region and examined by the pathologist in terms of the extent of granulation tissue, angiogenesis, mean number of fibroblasts, neutrophils, lymphocytes and macrophages, and the results were recorded. Data were analyzed by Mann-Whitney test. Both mouthwashes acted to the same extent to accelerate the repair process. And except for the percentage of macrophages on the third day (p= 0.028), other variables did not show any significant difference. Due to the similar effects of CR and Chlorhexidine 2% on oral wound healing and less side effects of the herbal mouthwashes, CR mouthwash can be used instead of chlorhexidine 2% to accelerate the oral linear wound healing.n Univ Med Sci 2019; 18 (4): 391-400 [Farsi]

The antimicrobial effect of phenytoin on ulcers has been addressed in few studies. The aim of this study was to determine the antimicrobial effect of phenytoin on common contaminating microorganisms of oral cavity ulcers in vitro. Three standard microbial species including Staphylococcus aureus, Actinomyces naeslundii, and Candida albicans were prepared. Twenty four-hour cultures of the species was accomplished on BHI Agar medium at 37°C in aerobic situation in an incubator. After 24 hour, 0.5 McFarland concentration were prepared from microorganism colonies. Meadow cultivation of microorganisms was done in plates containing BHI Agar medium. In each plate 4 wells were created for 4 concentrations of phenytoin (0.5, 1, 3, and 5%). Then one drop of each phenytoin solution was poured in the wells in certain concentrations. For each microorganism species, one well containing 0.2% chlorhexidine was prepared as positive control. The plates were placed in incubator and after 24 hour, diameter of non-growth halo around all wells was measured in all plates using a caliper. These steps were repeated three times to ensure the accuracy of process and results. Diameters of non-growth halo around colonies of Staphylococcus aureus, Actinomyces naeslundii, and Candida albicans were 0 millimeter in all four concentrations of phenytoin. Phenytoin was found to have no antimicrobial effect on common contaminating microorganisms of oral cavity ulcers in vitro.

Pemphigus vulgaris is an autoimmune and rare mucocutaneous disease with outbreak of 1 to 5 patients per 1 million people. The average age at onset of disease is usually 50 years. In this study four young females (mean age: 27.75 years) with pemphigus vulgaris are presented.
The first patient was a 28-year-old female complaining from various oral sores. She was diagnosed with pemphigus vulgaris based on biopsy. After treatment for 12 months, no sores were seen in other parts of her body. The second case was a 23-year-old woman with facial desquamation of upper and lower jaws. In pathology of oral lesions the diagnosis of pemphigus vulgaris was made and within 11 months follow-up after treatment, only the oral sores improved. The next patient was 30 years of age who had desquamated gingivitis and exclusive oral sores. She was also diagnosed with the same disease. After 12 months follow-up, oral lesions were controlled and no sores were seen in other parts of the body. The last case was a 36-year-old female with severe sores in the mouth associated with pemphigus vulgaris. But within 11 months of follow-up, despite treatments, the disease developed and large sores and blisters were seen throughout her body.
Pemphigus vulgaris is a serious disease that can lead to death if left untreated. The oral lesions are the first symptoms of this disease, but the clinical appearance of these lesions are not sores, therefore, biopsy and early diagnoses are required to prevent further complications.

Several studies have shown that herpes simplex infection is the most prevalence etiologic factor for oral ulcers in patients under chemotherapy, and in leukemia.The aim of this study was to investigate the clinical characteristics of oral ulcers and their relation with herpes simplex virus infection in patients undergoing chemotherapy. This descriptive and cross- sectional study was performed on patients receiving chemotherapy in Kerman hospital in 2006. Forty one patients (31 males and 10 females) with oral ulcers were studied. The most common type of cancer was acute lymphocytic leukemia diagnosed in 20 patients. Samples were prepared from ulcers by sterile swabs and were sent to laboratory for Polymerase Chain Reaction (PCR) procedure. The obtained data were analyzed by chi- square and t- test using SPSS 13.5 program.In this study, of all patients with oral ulcers, 75.6% were men and 24.4% were women. The result of PCR test was positive in 28 cases (68.3%). Thirty patients (73.2%) had single oral ulcer and 11 cases (26.8%) were suffered from multiple ulcers. The most prevalence sites for the oral ulcers were tongue, buccal mucosa, and lip. It was concluded that the etiologic factor of oral ulcers in more than 50% of the patients under chemotherapy was herpes virus infection. Therefore, the antivirus treatment with prophylaxis should be performed for these patients. In addition, it must be considered that the clinical symptoms in diagnosis of this infection are not sufficient, and other tests such as PCR should be used.