جستجوی مقالات مرتبط با کلیدواژه « زغال اخته » در نشریات گروه « پزشکی »

Hydatidosis is one of the most important zoonotic diseases in the world. The main issue of the treatment of this disease is elimination of protoscolices during surgery to prevent from causes of secondary cysts. The aim of this study was to evaluation of scolicidal effects of Cornus mas (C mas) and Lavandula officainalis (L officainalis) extract in vitro.

In this experimental study livers containing hydatid cysts were collected from Hamadan abattoir and transferred to parasitology laboratory. Under sterile conditions, protoscolices were removed from the cyst. Hydro alcoholic extracts of C mas and L officainalis were prepared. Then protoscolices was exposed with concentrations of 1, 10, 50 and 100 mg/ml at 5, 10, 20, 40 and 60 minutes. Finally the percentage of living protoscolices was examined by light microscopy and vital eosin staining.

In both extracts the highest scolicidal effect was observed in 60 minutes. L officainalis extract at concentrations of 1, 10, 50 and 100 mg / ml were 47%, 57%, 75% and 94%, respectively. Also C mas extract at the same concentrations 47%, 56%, 63% and 87% were observed. while the lowest of scolicidal effect for L officainalis and C mas in 5 minutes was observed 41%, 43%, 50%, 58%, and 41%, 43%, 46%, 51% respectively.

The highest scolicidal effect of L officainalis extract compared to C mas is probably due to the active ingredient of L officainalis, which can achieve better results by further study and identification and purification of effective material in its.

The growing interest of health products based on fruits and herbs has led manufacturers of oral health products to focus on fruits and plant products, which can be replaced by conventional chemical products to improve treatment methods and pay attention to the category of preventive dentistry.

In this study, the optical properties of cranberry and Cornus mas tea with Avantes broadband light source in the range of 300-1100 nm were investigated. The quasi-optical light spectroscopy test method includes 4cc of two cranberry and Cornus mas tea, which were prepared from about 1.7 g of dried fruit of these two fruits in 40 ml of 60oC water for 15 minutes. A review of 36 articles from PubMed, Scopus, and Google has been conducted by Usage Research from 1994 to 2020 to introduce the use of this fruit in the prevention and treatment of oral diseases.

Cranberry and Cornus mas tea, both have a maximum peak spectrum around 759.8 nm and a minimum transmission spectrum around 439 nm. There is an acceptable agreement between the results of the transmission spectrum (in the range of 300-1100 nm) and the absorption spectrum (in the range of 400-750 nm). Cranberries, like Cornus mas, are chemically rich sources of antioxidants and anthocyanins.

Spectroscopic studies in terms of optical interpolation features showed that the two fruits were not significantly different. Studies of chemical properties also suggest that polyphenols with anticariogenic properties and anthocyanins by inhibiting interleukins, reduce the use of antibiotics to prevent and treat periodontal disease, prevent bacterial resistance in they oppose dental treatments using antibiotics. Therefore, there is no significant difference between these two fruits in terms of photochemical properties, which shows that these two fruits can be a good alternative for each other in terms of health and treatment in oral use.

Due to the increase in the strains of antibiotic-resistant bacteria, it is necessary to obtain effective herbal compounds and nanocapsules synthesized from plant extracts to eliminate these strains.

The present research study was conducted to examine the antibacterial effects of Cornus mass extract and its synthesized nano-capsules on the bacterial strains resistant to antibiotics.

Samples including a combination of (urine, sputum, wounds and blood) of 436 hospitalized patients was collected and a number of 50 strains which demonstrated the highest resistance to antibiotics was separated to examine the antibacterial characteristics of the innovative compositions under study.

The findings showed that from among the 50 strains under study in 80% of the cases the E. coli bacteria and in 20% of the cases the Acinetobacter were the cause of infections. with the increase in the concentration of the extract, the size and dimension of nano-capsules increased so much so that in a concentration of 2.5 mg of extract, nano-particles as large as 72 nanometers was reported. Also, in fixed concentration of extracts diluted in more aceton, the size and dimension of nano-particles decreased to the extent that in a concentration using 15 mililitre of aceton, nano-particles equal to 66 nano meter was observed. Conclution: The findings relating to the antimicrobial characteristics of the Cornus mass extracts and its synthesized nano-capsules showed that respectively 36% and 56% of the strains under study possess antibacterial characteristics.

Antileishmaniasis drugs such as antimonials have problems such as disease recurrence, drug resistance, side effects and long-term treatment period. Therefore it seems necessary to search for new drugs, particularly herbal compounds with no side effects.

The present study was conducted to investigate the effect of hydroalcholic extract of Cornus mas on Leishmania major in vitro and wounds in Balb/c mice.

Various concentrations of hydroalcholic extract of Cornus mas were prepared using maceration method in 80% ethanol. Then, 100 μl RPMI medium containing 5×105 /well leishmania major promastigote was added to 96-well cell culture plates. Afterwards extract was added in each concentrations and the plate was incubated at 26 °C on 0h, 24h, 48h, and 72h. Then the MTT solution was added and absorbance was measured with ELISA reader in 570 nm in vivo: 60 Balb/c mouse after inoculation of L. major promastigote in the base their tail, after leishmaniasis lesions concentrations of 200 and 400 mg/kg of extract were injected to test groups one day in between for 30 days. Diameter and condition wound healing was recorded before and after the treatment. Then results were analyzed by SPSS software.

The findings revealed that the effect of C. mas on leishmania was dependent on dose of extract and time treatment also all concentrations of the extract could reduce the diameter of the wound and reduce parasitic load.

The results indicated that extract of C. mas had the favorable effect in leishmanicidal activity in experimental conditions and in the animal model. Based on this, it is recommended that the effect of the herbal ointment and gel in the future on leishmaniasis should be investigated.

Urinary tract infection is a common cause of outpatient visits of patients in medical centers and sometimes they need to be admitted because of their deterioration of an underlying condition or incapacitating. The aim of this study was the comparison of cranberry pills and nitrofurantoin pill to prevent recurrent urinary tract infection among 15-45 years old women who goes to the Kashani hospital’s clinic in Shahrekord.
This study was a clinical trial on 3 groups each one contains twenty one 15-45 years old women with recurrent urinary tract infection that are visited in Kashani hospital’s clinic. Patients were randomly divided into 3 groups. The first group received cranberry 500 mg tablets for 6 months and the second group received nitrofurantoin 100 mg during night for 6 months and the third group received placebo. These patients were followed up during the 6 months and once in two months the patient were examined clinically, Urinary Analysis, Urinary Culture, and in terms of recurrent cystitis.
In our study, no significant difference was observed between the groups in terms of recurrent UTI recurrence, although there were differences (P>0.005). Positive urine culture in nitrofurantoin group was 9.6% and in cranberry group was 19% and in placebo group was 33.4% during 6 months. In terms of dysuria in 6 months and the second time there was significant difference between placebo and cranberry (P=0.004). Dysuria in cranberry group was 14.2% and in placebo group was 56.2% during 6 months.
According to the results, taking the cranberry pills with the dose of 500 mg per day can reduce dysuria in patients with recurrent urinary tract infection.

For producing foods that promote health through gut microbial reactions, different types of food ingredients such as probiotics, prebiotics and bioactive plant secondary metabolites such as phenolic compounds can be used. The aim of this study is evaluating interaction effect between probiotics and phenolic content present in cornelian cherry juice during fermentation.
Cornelian cherry juice with natural and adjusted pH with sodium bicarbonate inoculated with three industrial and two native probiotic bacteria(L. rhamnosus, L. plantarom and L. casei) and two native probiotic bacteria (L. casei)(108cfu/ml). Then samples were placed at incubator (30°C) immediately after inoculation. Then changes in chemical characteristics such as pH, acidity, phenolic compounds content, anthocyanin content and antioxidant activity andviability of probiotic evaluated during 3days of fermentation with time intervals of 24 hours for samples with adjusted pH.Significant differences between the averages of obtained data were done by one way ANOVA test. Also differences between the averages of each treatment during time were done by repeated measure test by SPSS software at significant level of 0.05.
It can be said from the changes of phenolic content; antioxidant activity and anthocyanin content that degrading of tannins with high molecular weight during 48 hours of fermentation cause of increasing phenolic content and antioxidant activity in cornelian cherry juice and with Continuation of fermentation decrease cause of producing decarboxylase enzymes by probiotics. Also it is considered that native strain l. casei spp. T4 compare to others have more resistance against obstacle conditions of cornelian cherry juice and maintained its viability during fermentation and remained at initial number (8log cfu/ml).
Dietary supplements probiotics may, at least theoretically, can increase degrading of polyphenols, increase antioxidant activity and easily absorbing of these compounds in human body.

Recently, an increased demand for nondairy probiotic products comes from the popularity of vegetarianism, lactose intolerance, and high cholesterol content in dairy products. The objective of this study is evaluating the effect of refrigerated study on the viability of probiotics and some physicochemical characteristics in cornelian cherry juice. Cornelian cherry juice with natural and adjusted pH with sodium bicarbonate was inoculated with three industrial bacteria (L. rhamnosus, L. plantarom and L. casei) and two native probiotic bacteria (L. casei) (108 cfu/ml). Then the samples were placed in the refrigerator (4°C) immediately after inoculation. Next, the changes in chemical characteristics such as pH, acidity, phenolic compounds content, anthocyanin content, antioxidant activity, microbial characteristics (such as enumeration of live probiotic cells), and sensory properties were evaluated during 4 weeks with the time intervals of one week for the samples with adjusted pH. Significant differences between the averages of obtained data were checked by one way ANOVA test. Also differences between the averages of each treatment during the refrigerating time were examined by repeated measure test using SPSS software at the significant level of 0.05. Data analysis showed that treatment type, storage period and interaction effect of these two factors have significant effects on the changes of physicochemical characteristics and probiotic viability (P<0.05). The results revealed that native probiotic strain L. casei spp. T4 compared to other strains maintained its viability at 8.67 log cfu/ml after 4 weeks of refrigerated storage. Also there were the most changes in physicochemical characteristics in the cornelian cherry treatments containing this strain, which is a marker of fermentative activity during the refrigerated storage. The results showed that cornelian cherry juice because of low pH and presence of inhibitor phenolic compounds has negative effect on viability of probiotics, especially industrial strains during the refrigerated storage.

Diabetes mellitus is a common endocrine disorder that affects 100 million people annually. It is considered as an important risk factor for clinical disorders such as nephropathy, neuropathy, retinopathy and cardiovascular diseases. The aim of this study was to examine the effects of cranberry (Cornus mas L.) on blood glucose and HbA1C levels in patients with type 2 diabetes. This randomized clinical trial, double-blind, placebo-controlled performed in the period of 6 weeks. 60 patients aged 41-65 years with diabetes participated in the study. Patients were randomly divided into control, consumer capsule placebo (n= 30) and group use, Cornus mas capsules. At the beginning and end of the study, fasting blood sugar (FBS), and glycosylated hemoglobin (HbA1c) were measured using t-test and ANCOVA. There was no significant difference between the groups at baseline about the characteristics of the subjects (FBS, HbA1c, age). Cornus mas group compared with the control group receiving at the end of 6 weeks, the factors FBS and HbA1c decreased significantly (P< 0.05). Reducing FBS and HbA1c in patients with diabetes consumed Cornus mas for control is valuable. These changes in fasting blood glucose and glycosylated hemoglobin levels may be the result of anthocyanin compounds in the level of Cornus mas.

Urinary tract infections (UTIs) are the most common medical complication experienced by individuals living with SCI. Several factors are responsible for the high prevalence of UTIs in individual with SCI. Concerns regarding the overuse of antibiotics in individuals with SCI and emerge multi-drug-resistant bacteria, has prompted consideration for consumer –directed alternatives to improve urinary tract health. This study was designed to evaluation of cranberry juice on bacteriuria and pyuria and in spinal cord injured patients with neurogenic bladder in Shahrekord, Iran. This study was randomized, double-blind, placebo-controlled trial. 60 patients (51 male and 9 female) with creatinine levels below 1. 5 mg/dl and in the analysis of their urine white blood cell (WBC) counts were greater than 10 in a high-powered field (pyuria) or with a presence of bacteriuria (>= 104 cc/ml) in their urine culture selected in this study. Urine analysis and culture were carried out at before and after intervention. Samples was divided into two two groups of 30. The case patients were given a dose of 250 to 300 ml of cranberry juice cocktail with 30% concentration, daily with meals. The control group was fed the same amount of a placebo cocktail. After two weeks, first morning urine analysis and culture test were done. Data collected and analyzed using K-squared method using the SPSS software and Paired-T test technique. Urine analysis and culture before and after interventions show, Urinary PH in case and control groups did not any significant statistical difference before and after intervention (P>0. 05). A change in pyuria and bacteriuria levels in case patients was observed after the treatment which was statistically significant (P<0. 05). However, after treatment, the bacterial colony count in the case patients had dropped as a result of the cranberry juice consumption. the urine foul-smell was noticeably reduced in treated case patients (CI>95٪). Consumption of cranberries can be effective in treating SCI patients with UTI under certain conditions. The effectiveness was most profound in patients with normal GFR who did not use urinary catheter for urination. The effectiveness was especially seen in short term reduction of pyuria and bacteriuria levels and in reduction of foul-smelling of patient's urine.

Background and Today cancer is considered as one of the leading causes of death worldwide. An impressive number of modern drugs used in cancer treatment are isolated or derived from natural sources based on their use in traditional medicine. Cornus mas L. (Cornaceae) has medicinal applications in treating a wide range of diseases such as cancer. This study was designed to evaluate the Cytotoxic effect of Cornus mas L.fruit hydroalcoholic extract on normal and cancer cell lines. Rip fruit and unripe fruit extract was prepared by soxhlet extraction method. The anticancer activity of different concentrations of the extract (0, 10, 50, 100, 150, 200, 250µg/ml) in three cell lines MCF7 (breast cancer), HepG2 (liver cancer), and CHO (normal hamster ovary) were examined using MTT. Statistical analysis was performed using SPSS V.16. The findings revealed time and dose-dependent inhibition and also significant differences between the levels of IC50 of unripe and ripe fruit in all cell lines (P< 0.05). Also, the level of IC50 of unripe and ripe fruit on normal cell lines was significantly different from that of the cancer cell lines (P< 0.05). However, cytotoxicity of unripe fruit was found more than ripe fruit. This study showed that hydroalcoholic extract of Cornus mas L.(unripe and ripe), have a considerable cytotoxic effect on cancer and normal cell lines and should be further investigated to find effective compounds present in the fruit extract. Hence, effective steps could be taken towards finding new drugs in treating cancer.

Metabolic syndrome consists of a group of metabolic disorders which is associated with increased cardiovascular risk. Several studies are conducting in regard to the effects of plant polyphenols as an alternative treatment for metabolic syndrome. Therefore, the goal of the present study was to assess the effects of cranberry supplement on some features of metabolic syndrome. In this double-blind randomized clinical trial, 48 women with metabolic syndrome were followed for 8 weeks, divided into two groups: intervention and control. The participants in the intervention group received 2 capsules of cranberry extract (equal to 400 miligrams of cranberry extract) and the participants in the control group received two placebo capsules daily. Serum levels of glucose, insulin, lipid profile, oxidative stress marker, fat tissue distribution and blood pressure were measured at the beginning and after 8 weeks of the study, and were compared between the two groups. Compared to the control group, HDL- cholesterol level increased significantly in the intervention group (P<0.05). Also a significant reduction was seen in systolic blood pressure and waist circumference in the intervention group (P<0.05), whereas no change was made in levels of glucose, insulin, insulin resistance index and oxidative stress marker. In the present study, cranberry supplement increased HDL-cholesterol level, decreased blood pressure and waist circumference in patients with metabolic syndrome, but did not have any effect on other lipid indices and oxidative stress marker.

Diabetes is a chronic disease characterized by elevated blood glucose levels and disturbances in carbohydrate, fat and protein metabolism. Cornus mas (cornaceae) is one of the major medicinal plants in Asian countries that cotained high level of anthocyanins with potential to prevent hyperglycemia and obesity. In this study, we investigated antidiabetic effects of cornus mas in compared to glibenclamid as a standard drug on alloxan-induced diabetic rats. Thirty two male Wistar rats (190-240 g) were divided into four groups (n = 8): group 1 nondiabetic rats, group 2 alloxan-induced diabetic rats with no treatment, group 3 alloxan-induced diabetic rats treated with glibenclamid (0.6 mg/kg body weight) and group 4 alloxan-induced diabetic rats treated with cornus mas fruit 2 g daily for 4 weeks. Diabetes was induced by single intraperitoneal injection of alloxan 120 (mg/kg body weight). The results indicated that treatment with cornus mas fruit orally significantly reduced blood glucose levels and increased insulin levels in treatment of diabetic rats compared with no treatment diabetic group. Concurrent histological studies of the pancreas demonstrated the same results. On the base of histological results, cornus mas have a significant on increasing the size of pancreatic islets than diabetic groups (P < 0.05). Our results showed that cornus mas fruit has antidiabetic effects and can improve pancreas damage caused by free radicals in diabetes. The effects of this fruit can occur due to the presence of anthocyanin and other antioxidant compounds.