جستجوی مقالات مرتبط با کلیدواژه « سرطان سرویکس » در نشریات گروه « پزشکی »

Cervical cancer is the fourth most common cancer among women worldwide and is a heterogeneous disease. The exosomal miRNAs could be applied as diagnostic biomarkers and therapeutic targets in cervical cancer. The present study was performed with aim to use a bioinformatics analysis to identify key miRNAs and related genes and pathways in exosomes derived from cervical cancer cells.

In this study, the differential expression of exosomal miRNA and RNAs in healthy and HeLa cells was investigated by analyzing the GEO database for miR-seq and RNA-seq in R software. Subsequently, overlapped miRNA target genes and differentially mRNA from exosome were selected and then, GO and KEGG pathway analysis was performed. The overlapped genes were integrated to construct a PPI network and hub genes selection.

In the present study, it was observed that 31 miRNAs were upregulated and 16 miRNAs were downregulated in exosomes. Also, 341 overlapped genes from miRNAs targets and mRNA-seq were selected for future analysis. GO analysis indicated that overlapped genes were significantly enriched in the leucine transport, MAP kinase phosphatase activity, and glutamine transport. KEGG analysis suggested that the genes were enriched in cellular senescence, p53 signaling pathway and cell cycle. The top ten genes including CCNB1, BUB1, KIF20A, MKI67, FOXM1, BIRC5, NCAPH, ZWINT, GINS2, and ASF1B were identified from the PPI network.

The results identified key miRNAs with altered expression and characterizing key genes in exosomes derived cervical cancer cells. This study will provide novel insights to determine the potential mechanisms associated exosomes derived from cancer cells in cervical cancer progression.

Cervical cancer is one of the most common causes of cancer death in women. The present study was performed aimed to evaluate and compare Pap smear and colposcopy findings as cervical cancer screening methods in patients reffered to Amir Al-Momenin hospital of Semnan.

In this cross-sectional and retrospective study, liquid-based Pap smear and colposcopy results of 200 colposcopiy candidates referred to the clinic of Amir Al-Momenin Hospital were studied in 2016-2018. In this study, all patients who had undergone colposcopy for various reasons and also had done Pap smear were examined. The data of each patient were recorded in a researcher-designed checklist. The checklist consisted of demographic and main data sections. The abnormalities in Pap smears included pre-invasive and invasive positive cervical lesions. The abnormalities in colposcopy included pre-invasive and invasive positive cervical lesions. Data were analyzed by SPSS (version 23) and independent t-test, chi-square, or Fisher's test. P<0.05 was considered statistically significant.

From 200 patients, 40 cases (20%) showed positive Pap smear. Also, colposcopy results showed that 17 patients (8.5%) had positive findings. There were signficant differences in the frequency of positive and negative results of Pap smear and colposcopy in patients with symptoms of post coital bleeding (P=0.021), intermenstrual bleeding between periods (P=0.035), vaginal discharge (P=0.009), and pelvic pain (P = 0.011). 

The non-positive results of Pap smear in positive cases of colposcopy emphasizes the quality control of Pap smear procedures and indicates the need to use colposcopy in suspicious cases. Direct colposcopy is recommended in case of warning signs such as post coital bleeding and abnormal discharge.

One of the most important causes of cancer death in women is cervical cancer. Early detection of precursors or early stage disease is possible using low-cost and available screening approaches, and this is associated with a reduction in patients' mortality. This study was performed with aim to compare colposcopic findings and histological findings in colposcopic cervical biopsy specimens.

This cross-sectional study was performed in 2016-2017 on 200 patients referred to the gynecology and oncology clinic of Ghaem Hospital in Mashhad with colposcopic indications. These indications included abnormal Pop smear, post coital bleeding, abnormal appearance of cervix and vagina on examination, and existence of high-risk HPV virus in tests. If there was a history of abnormal Pap smear or biopsy due to suspected cervical lesions, the subjects were excluded from the study. Initially, the cause of colposcopy, Pap smear and HPV status were extracted using the information in the file. In the next stage, under the supervision of two gynecologists with oncology fellowship, colposcopy was performed and the findings during colposcopy were recorded. Finally, the data were analyzed with the pathological report. Data were analyzed by SPSS software (version 23).

Physician diagnosis at the end of colposcopy was abnormal in 162 patients (81.5%). As a result of colposcopic pathology, the results showed abnormal pathology in 120 patients (60%). The most common pathologies reported were CIN1 (87.4%), CIN2 (9.2%), and CIN3 (2.3%), respectively. There was a correlation between the colposcopic result and the pathological result in 21% of patients (n=42). The sensitivity of colposcopy compared to the pathological result was 89% and its specificity was 30%. The positive and negative predictive value of colposcopy was 65% and 64% compared to the pathological result.

Colposcopy has an acceptable sensitivity in the diagnosis of cervical pathological lesions, but has a low specificity. Therefore, this screening / diagnostic test can be used in one of the multi-stage screening stages (after the initial screening with Pap smear) and if there are any abnormalities during the colposcopy, biopsy be performed.

Today, cancer is one of the health concerns in modern societies. Cervical cancer occurs when abnormal cells grow in the cervix. Cervical cancer is one of the fatal cancers in women. Computational models are suitable for simulating complex phenomena such as cancer. Studying cervical cancer through computer modeling and simulation is an effective way to investigate and predict tumor behavior and patients’ response to treatment methods. The objective of this study was to develop a model to simulate the growth and treatment of cervical cancer and study it and analyze the process of chemotherapy in different stages of cervical cancer.

In this research, library study and NetLogo software tool were used for modeling and simulation. First, the anatomy of the uterus, cervix, fallopian tubes, vagina, lymph nodes of the uterus, liver, and lungs was designed and modeled. Then, different stages of cervical cancer were modeled according to TNM system and based on the way the cancer cells spread, tumor growth and spread were simulated and investigated in each stage. The control of tumor by chemotherapy mechanism was also modeled.

The model developed in this study provided the possibility of observing and investigating the growth and spread of tumor in different stages of cervical cancer. Predicting how the cervical tumor grows and behaves is one of the capabilities of the developed model.

This model can be used as an appropriate tool to understand different stages of cervical cancer.

Cervical cancer is one of the most common cancers among women. Early diagnosis of this disease can reduce mortality among patients. So, women's screening is very important. One of the most common screening methods in this field is Pap smear screening and human papillomavirus test. Therefore, this study was performed with aim to compare these two methods in cervical cancer screening.

In this systematic review of systematic review research, for finding the systematic review and meta-analysis articles about cervical cancer screening, the databases of pubmed, Scopus, science direct and Cochrane were searched using the keywords of " Cervical cancer screening", " Pap Test", "HPV Test " and " cotest " from 2015 to 2018. The quality of the included studies was assessment by the AMSTAR checklist.

sensitivity of HPV in two studied researches was 94% and 89.9%, and its specificity was 90% and 89.9%, while the sensitivity of Pap smear was 70% and 72.9% and its specifity was 95 % and 95.3 %. In the Cotest experiment in comparison to the cytology test, false positives results ranged 5.8 to 19.9 versus 6.2 to 10.9.

According to the results of the studies, it seems that HPV test had more sensitivity, less specificity and more false positive results than Pap smear. However, regarding the great importance of this issue in clinical decisions, the final conclusion needs to more evaluation.

Cervical cancer is one of the significant causes of mortality in the premenopausal period and the second most common cancer in women. According to the screening test and pap smear, a physician can diagnose cancer in the early stage. Therefore, identifying the preferred and novel method of treatment is crucial. This review article performed based on recent data from PUBMED, MEDLINE, ISI, and other reliable databases. Conization or extra facial hysterectomy is appropriate in women with a micro-invasive type of cancer. Fertility preserving surgery such as conization preferred in patients in reproductive age that tend to save the fertility, tumor size is less than 2 centimeters, without invasion to lymph nodes and parametrium and unusual pathologic features such as neuroendocrine. Radical hysterectomy is the preferred method of surgery in stage IA2 and IIB1. Some oncologist surgeons recommend radical hysterectomy in stage IB2 and IIA with small size tumors and without lymph node invasion. For radical hysterectomy in tumors larger than 2 centimeters, laparotomy is the preferred method in comparison to the micro-invasive method. Ovarian metastasis is less common in case of squamous cell histology compare with adenocarcinoma, and ovary can preserve if pathology is squamous cell.

 Researches have shown that promoter methylation of the CADM1 gene is one of the main mechanisms is to silence its expression in cancer cells. The objective of this study was to determine the methylation pattern of the CADM1 gene promoter and to quantify the human papillomavirus.

In this research, 75 tumor tissues and 75 tumor marginal tissue samples taken from patients with definitive diagnosis of cervical cancer were examined. After extraction of DNA and ensuring the quality and quantity of DNA extracted by spectrophotometry and the Agarose gel electrophoresis method, the methylation pattern of the CADM1was performed by the HRM method. Determining the methylation pattern of the CADM1 gene, without considering the type of involved variants was performed by using the Eva Green method and comparing the high-resolution melting point and HPV quantities were determined after isolation from the block.

Methylation of CADM1 gene in cervical tumor cells increased significantly (P< 0.0001) in comparison with the tumor margin before and after radiotherapy. But the change in the level of methylation of tumor cells before and after radiotherapy was not significant. This means that radiotherapy does not affect the level of methylation of the CADM1 gene. Moreover, the level of methylation of CADM1 gene in patients with HPV titer higher than 500 ml / IU was significantly more than that of patients with HPV titer lower than 500 ml / IU.

Use of DNA methylated of the cancer cells as a prognosis for cervical cancer in HPV positive women it’s appropriate, also the CADM1 gene can be used as a marker of cervical cancer.

Gynecologic cancers are the important cause of women's mortality in the world. Considering the importance of epidemiological recognition of gynecologic cancers in regional form for planning the preventive measures, this study was performed with aim to assess the epidemiologic characteristics of patients with gynecologic cancers referring to Mashhad oncologic centers in 1982-2016.

In this cross-sectional study, after evaluation of all patients’ files recorded in the last 35 years, the required data were extracted and recorded. The study period was categorized into 4 intervals: before 1990, 1991-2000, 2001-2010, and 2011-2016. The relative frequency, mean age at the time of diagnosis, and the 35-year trend were then assessed. Data were analyzed by SPSS software (version 16) and Chi-Square, Anova, and Scheffe tests. P 

Among 2953 studied patients, mean age was (49.32 ± 13.69 years. The highest mean age was observed among the patients with uterine body neoplasms (52.21±12.49) and the lowest mean age in those with ovarian cancer (46.09±16.09). The mean age at the time of diagnosis of ovarian cancer has significantly increased in the last decades (p<0.001) while decreased in those with cervical cancer (p=0.017). Cervical and ovarian cancers had the highest relative frequency during the entire study period (39.3% (1161 cases) and 36.6% (1080 cases), respectively). There was also a significant difference in the frequency of various cancers across different decades (p<0.001).

Cervical cancer was the most frequent neoplasm in this study. The mean age of diagnosis had increased in patients with ovarian cancer and decreased in cervical cancer. Since cervical cancer can be controlled by preventive measures, more attention to screening of this cancer is recommended.

Cervical cancer is the second most common cancer in less developed countries. Chemoradiation is the standard treatment for advanced cervical cancer, but there is a lack of radiotherapy equipment in developing country. Therefore, this study was performed with aim to evaluate the pathologic response, treatment complication and survival rate of patients with locally advanced squamous cell carcinoma (SCC) of cervix who were not candidate for chemoradiation with use of chemotherapy before surgery.

In this single group, before-after randomized clinical trial, 24 patients with FIGO stages IB2, IIA2, and IIB squamous cell carcinoma (SCC), who were not candidate for standard chemoradiation due to different causes, received 3 courses of neoadjuvant paclitaxel (135mg/m2)+ Cisplatin (75mg/m2) chemotherapy regimen. Then, surgery was performed. Clinical response to neoadjuvant chemotherapy and treatment side effects were assessed after each course. Wertheim hysterectomy was done 4 to 6 weeks later in those with favorable response. In the absence of major risk factors in the surgical pathology, patients received 3 additional cycles of adjuvant chemotherapy. In high risk patients, adjuvant chemoradiotherapy was performed. Data was analyzed by SPSS software (version 21) and Chi-square, and Kaplan Mayer tests. P

Among 24 patients, 13 cases (54.2%) and 17 (73.9%) had FIGO stageIIB and gradeII tumors, respectively. Parametrial involvement was presented in 13 patients (54.2%). Seven patients were excluded. 17 patients underwent surgical resection. Four high risk patients and were candidate for chemoradiation. Clinical and complete pathological response rate were 17 cases (70.8%) and 8 cases (47.1%), respectively. With a median follow up of 18.5 months, mean of overall survival and disease free survival of patients treated with the study protocol were 24.51 and 25.71 month, respectively. The mean of overall survival of whole patients (24 cases) was 30.8 month (CI: 95%, 29/38-32/26).  

Neoadjuvant chemotherapy in patients with locally advanced cervical cancer despite acceptable pathologic response is not associated with survival advantage.

Cervical cancer is the second most common cancer after breast cancer in women, despite being preventable, a large number of women lose their lives as a result of this disease every year. This study aimed to determine the effect of the educational intervention based on Health Belief Model on performing Pap smear in 20-65 years old women in Yazd.
This study was a quasi-experimental in 2014. The study population included women who referred to health centers in Yazd, among them, 87 women were selected using randomized cluster sampling and divided into case and control groups. Data collection tool was the questionnaire. Two training sessions were performed by means of lectures and group discussions on overviews of cancer, cervical cancer; the serious consequences of the disease, and Pop Smear; its procedures and benefits. Both groups were evaluated before and two months after intervention. Data were analyzed using SPSS software version 20 and statistical independent t-test and pairwise t-test.
The results showed that before the intervention, there was no significant difference between the mean score of the model constructs in control and experimental groups. After intervention, the mean scores of perceived susceptibility (p The results of the study showed the efficiency of the health belief model on performing Pap smear test in women in Yazd. Based on this model, designing and implementing educational interventions improve the Pap smear performance in women.

Ovarian cancer is a common malignancy in women, the major presentations of which are gastrointestinal symptoms. The intra-abdominal metastasis of ovarian cancer often occurs in the peritoneal cavity, while cervical metastasis has rarely been reported. This study aimed to present the case of a metastatic epithelial ovarian cancer to the cervix.
Case Report: A 58-year-old woman (gravida 3) was admitted with a history of postcoital bleeding in the oncology clinic of a teaching hospital affiliated to Mashhad University of Medical Sciences in 2016. Colposcopic examination was performed due to the abnormal appearance of the cervix, and pathology results confirmed squamous cervical cancer. Considering the early stage (II A) of the disease, the patient underwent a radical surgery. In laparotomy, due to the extent of the intra-abdominal metastasis similar to that of ovarian cancer, only omental biopsy was possible. The pathology report of the specimen showed the metastasis of the serous papillary adenocarcinoma of the ovary to the omentum. Furthermore, repeated review of the pathology of the cervical specimen was indicative of ovarian metastasis to the cervix. Due to the advanced stage of ovarian cancer, chemotherapy (taxol-carboplatin) was recommended, followed by standard optimal surgical cytoreduction. Afterwards, the patient was followed-up for ovarian cancer. After less than six months, she experienced pelvic and abdominal metastasis and is currently receiving palliative chemotherapy.
Cervical metastasis is an unusual occurrence at presentation and during the progression of epithelial ovarian cancer. As an initial symptom of ovarian cancer, postcoital bleeding is rare and should be considered in the patients with cervical cancer who are at the risk of metastatic lesions from the adjacent tissues.

Background and Tumors are one of the most important threats to human life and improving the drugs used in their treatment is always necessary. Isatin is found in many plants and also synthesized through different methods. Many studies have been done on Isatin ring, including the construction of Dibromoisatin derivatives that exhibit anti-cancer effects. The aim of this study was to determine the cytotoxic effects of Dibromoisatin derivatives on cervical and liver cancer cells.
In this study, 10 Dibromoisatin derivative made at concentrations of 1, 50, 100, 200, and 400 µg/mL were tested against cervical (HeLa) and liver cancer cell lines (HepG2). The cell viability was assessed by MTT assay and the IC50 value was calculated in PRISM software.
Comparing the cytotoxic effects of Dibromoisatin derivatives showed that the highest cytotoxic effects in both cell lines was detected in composition No. 9 with IC50 value of HepG2= 1.194 and IC50 value of HeLa= 0.025.
These derivatives were more effective against liver cancer cells and some Dibromoisatin derivatives were found to have high toxicity against cancer cells, therefore, they could be of great benefit in improving the drugs used in chemotherapy.

Cervical cancer is the third most common gynecologic cancer in women worldwide. Cervical cancer has lower incidence and mortality rates than uterine corpus and ovarian cancer, as well as many other cancer sites. Unfortunately, in countries that do not have access to cervical cancer screening and prevention programs, cervical cancer remains the second most common type of cancer. Staging of the disease is made clinically. The aim of this study was to evaluate the role of magnetic resonance imaging (MRI) for diagnosing the invasion of cancer to organs and staging of cervical cancer and the relationship between clinical and pathological findings and the sensitivity and specificity of the assay in cervical cancer.
The study included records of 40 patients with cervical cancer that undergo surgery or Chemoradiation in Firoozgar University Hospital. In this study that made retrospectively, non-randomized, the MRI reports and clinical findings records and pathology results was discussed. The sensitivity and specificity of MRI for diagnosing the invasion to parameters, bladder, rectum, vagina, pelvic wall and it’s accuracy to determine tumor stage has been set.
A total of 40 patients with pathology information of cervical cancer was retrospectively reviewed in the study. The patients were 28-83 years old by mean age of 49.3 Pathology of cervical cancer in 80% of cases was SCC, 15% adenocarcinoma and 5% melanoma. The sensitivity and specificity of MRI for diagnosing invasion of parameter was 76% and 88%. The sensitivity of MRI in the detection of bladder invasion was 100% and specificity of 100%. The sensitivity of MRI in the diagnosis of rectal invasion was 50% and specificity of 100%. The sensitivity of MRI in the diagnosis of pelvic wall invasion was 100% and specificity of 86%. Sensitivity in detecting invasion into the upper third of the vagina was 100%.
Overall, this study showed a good sensitivity and specificity for detecting invasion into the bladder, vagina, pelvic wall and parameters and good specificity for the diagnosis of rectal invasion and acceptable accuracy at 67.5% for detection of tumor stage by MRI show.

Pre-sacra Epidermoid cyst is a rare diagnosis in middle-aged women which is often asymptomatic and discovered incidentally. Pre-operative biopsy is not recommended and surgical resection is the best diagnostic and therapeutic modality. This article presents a case of pre-sacral epidermoid cyst which was discovered during the staging of cervical cancer. The patient was a 47-year-old woman complaining of menometrorrhagia in May 2015. After gynecological examination and biopsy, squamous cell carcinoma of the cervix was diagnosed for her. CT scan and ultrasound for ruling out cervical cancer metastasis revealed a large cystic mass in pre-sacral area. The patient initially underwent hysterectomy and bilateral salpingo-oophorectomy. Then, laparotomy was performed for resection of pre-sacral lesion in Mashhad Omid oncology hospital. Histopathological examination showed the diagnosis of pre-sacral epidermoid cyst. Epidermoid cyst should be considered in the differential diagnosis of any asymptomatic pre-sacral cystic lesion in middle-aged women. Surgery is the optimal diagnostic and therapeutic method. The selection of surgery route depends on the size of the lesion and the surgeon's experience.

Cervical cancer is the most common gynecological cancer. Due to the effect of radiation on cervical mucosa، evaluation of response to radiotherapy with pap smear is controversial. This study was performed with the aim to evaluate the value of post-radiation pap smear as a predictive factor of tumor response. This cross-sectional study was performed during three years (2005-2008) on 30 patients with stage IIB cervical cancer who referred to oncology department of Mashhad Ghaem and Omid hospitals. Patients who continued their follow up with pap smear and gynecologic exam at the end of radiotherapy، 1، 3 and 24 months later were entered to the study. Response to radiotherapy based on pap smear and gynecologic exam at different times after the end of radiation were compared with each other and also were compared with the results of similar evaluations at the second year. Those with abnormal pap smear and diagnosis of recurrence at the end of third month were excluded from the study. According to complete concordance between pap smear and clinical exam 24 months after radiotherapy، we assumed this time as the reference for response. The concordance rate of pap smear results at the end of radiation treatment،1 month and three months after treatment، with pap smear results 24 months after radiation were 70% (p=0. 088)، 50% (p=0. 043) and 97% (0. 033)، respectively. The pap smear had 100% sensitivity، 95. 8% specificity and 97% diagnostic accuracy at the end of third months after radiation. Pap smear at the end of radiotherapy did not indicate treatment failure or poor patient outcome. Otherwise، Pap smear 3 months after radiation can be used as a predictive factor for response to treatment.

Cancer is the second most common cause of death in women during reproductive ages; however, the occurrence of cancer during pregnancy is very uncommon. With increasing the rate of pregnancies in advanced ages, the incidence of cancer during pregnancy is also being increased. Cervical cancer is one of the most common cancers presenting during pregnancy. This study was performed aimed to review the most important diagnostic and therapeutic approaches in patients with cervical cancer during pregnancy. in this narrative review article, the most recent research, reviews, guideline articles and current evidences were selected and reviewed with the main keywords of pregnancy, cancer, cervical, diagnosis, chemotherapy, radiation and surgery and its equivalents; then, the most important and strongest diagnostic and therapeutic recommendations were provided. 34 articles used in this study consisted of all articles in the PubMed database in the time period of 2000 to 2014. Approximately 1-3% of all cervical cancers are diagnosed during pregnancy, breast-feeding or one year following delivery. Pregnancy is a good opportunity for early diagnosis of cervical cancer. Maternal and fetal health is the most important diagnostic and therapeutic challenges in pregnancy. Fortunately, due to routine health care service and screening during pregnancy, most cervical cancers are detected in early stage. However, due to concern about fetus safety, there are many limitations and contraindications for using diagnostic and therapeutic methods during pregnancy. Treatment type depends on disease stage, tumor histology and gestational age and should be individually determined in each case. Cervical cancer in pregnancy can be treated successfully. In general, by considering a balance between the mother health and fetal health as the primary goal, evidence-based therapeutic approaches can be used in these patients. Survival of the mother should not be compromised due to delay in beginning of treatment.

Persistent infection with high-risk human papillomavirus (HPV) is one of the most important risk factors for developing cervix cancer. Since cell culture and serological methods have no diagnostic value for the detection of this virus and its variants, the importance of molecular methods such as PCR in the early and definite diagnosis of such virus becomes evident. This study aimed to evaluate the frequency of HPV18 based on detecting E6 gene in paraffin block samples using the PCR method.

In this study, 69 out of 150 cervix samples of precancerous and cancerous lesions were collected during 2007-2012. DNA was extracted from paraffin blocks using the phenol/chloroform method. Two L1 and E6 consensus primers were used to evaluate the HPV and 18 HPV, respectively.

Among 69 patients with cervix cancer, 53 (76.8%) cases were HPV-positive and 16 (23.19%) HPV-negative. Twelve out of 53 (17.39%) HPV-positive cases were HPV18- positive. Moreover, 6 cases were diagnosed with cervical intraepithelial neoplasia II, III and 6 with squamous cell carcinoma.

Results of the study confirm the previous reports concerning the relationship between HPV and cervix cancer. Considering the efficiency of DNA extraction and PCR protocol, we can use the test in pathology labs with simple and inexpensive facilities.

Today with an increasing frequency of HIV infection around the world، its epidemiological studies is becoming more important. This study aimed to evaluate the cervical smear in human immunodeficiency virus (HIV) infected patients and also its association with CD4 counts among an Iranian population. In a case-control study، 247 women، 58 HIV infected cases and 189 healthy controls، were included. Liquid-based cytology cervical smears and hematologic findings were compared between cases and controls. The frequency of abnormal smear was significantly higher in cases 20. 7% compared with controls 3. 2% (p<0. 001). The mean CD4 count was significantly lower in cases with abnormal smear compared with cases with normal smear (573. 0 ± 306. 9 vs. 383. 7± 123. 6; p=0. 042). ‍ Undertaking a serious effort toward provision of gynecological care and cervical cancer screening at the same health center as HIV care، in Iranian HIV infected women is suggested.

Although current treatment options for cervical cancer rely on platinum-based chemoradiotherapy, individualized approaches to therapy may improve response or reduce unnecessary toxicity. Overexpression of Excision repair cross-complementing 1 (ERCC1) has been associated with Cisplatin resistance in some tumors. We hypothesized that ERCC1 overexpression is related to treatment response. 32 patients with cervical cancer were enrolled. Malignant tissue was isolated from pretreatment biopsies, and quantitative real-time reverse transcriptase polymerase chain reaction assays were performed to determine ERCC1 expression. Patients were divided to ERCC1 positive and ERCC1 negative. Response to chemoradiotherapy was evaluated and compared among the two groups. The mean age of participants was 56.6±12 years. Objective response was obtained in 24 patients (75%). ERCC1 was 2.8 times higher in patients who did not respond to treatment compared with the responders (OR: 2.8). ‍ Assessment of ERCC1 expression in tumoral tissue is possible in the clinical setting and predicts response to chemoradiotherapy. Further studies are necessary for final judgment.