جستجوی مقالات مرتبط با کلیدواژه « سرطان های روده بزرگ » در نشریات گروه « پزشکی »

The aim of this research is to improve Colorectal Cancer screening trying to control an individual lifestyle to reduce the probability of developing Colorectal Cancer, detect the disease in early stages, and then accelerate the screening of risky individuals and postpone the screening of ones with low risk. In this retrospective study information of 309 individuals including 84 patients whose diagnosis had been between years 2006 to 2013 and 225 healthy individuals were collected through phone or face to face interviews and exploring patient medical records. Popular techniques to develop classification models in clouding support vector machine, naive bayes, k-nearest neighbor, and decision tree were applied. Finally actionable models were determined according to both types of measures and based on domain-driven data mining approach. The results show that most of the developed models have acceptable evaluation results in predicting lifestyles. The developed non-technical measure clearly distinguishes the value of every false negative prediction and every true positive prediction itself. And finally, the actionable classifiers have been selected for domain practitioners. Only two of all the developed classifiers could satisfy both technical and non-technical measures. The results showed developed models must not only be evaluated by technical measures, but also be evaluated by medical domain interestingness, and also their application ability to actual problem solving should be explored.

Studies show polymorphism in leptin gene cause increase in level of leptin hormone and increased level of leptin hormon is associated with abosity، insulin resistance and increased risk of colorectal cancer. The aim of this study was to assess the incidence of leptin gene polymorphism rs 7799039 in Tehran and to investigate the influence of this polymorphism in increased risk of colorectal cancer. In this case-control study، genotyping of the leptin gene were determined in series of 108 colorectal cancer patients and 108 controls by using polymerase chain reaction and restriction fragment length polymorphism genotyping assays (PCR-RFLP). The statistical analysis was done with SPSS 16. The frequency of A allele in patient group and control group were 52. 8% and 62. 5%، respectively. In this study allele frequency showed significant deference between patient group and control group (P=0. 04). In patient group frequency of GG، GA، AA for leptin gene were 19. 4%، 55. 6% and 25%، respectively and in control were 38%، 49. 1% and 13%. These findings suggest that polymorphism Leptin rs 7799039، is associated with decreased risk of CRC