جستجوی مقالات مرتبط با کلیدواژه "ضایعات مغزی" در نشریات گروه "پزشکی"

Traumatic Brain Injury (TBI) is one of the leading causes of death in younger people. It activates neuroinflammatory responses that play an important role in breaking the blood-brain barrier and resulting in brain edema. Various studies have indicated the anti-inflammatory effect and the ability of lettuce extract to reduce oxygen free radicals. Therefore, it is expected to improve the consequences of TBI. Therefore, this study aims to investigate the anti-inflammatory effect of lettuce extract on the outcomes of patients with TBI admitted to the Intensive Care Units (ICUs).

This is a randomized clinical trial. Patients were divided into two groups of intervention (n=15) and control (n= 15). In the intervention group, patients received 250 g of lettuce aqueous extract twice a day for 7 days. In the control group, a placebo was administered.  For all patients, the levels of inflammatory markers and variables related to the patient outcome were recorded. The data were analyzed in SPSS v.18 software using t-test, Mann-Whitney U test, repeated measures ANOVA, and chi-square test.

There was no significant difference between the study groups in any study variables (P>0.05).

Lettuce aqueous extract is not effective in improving the outcomes of patients with TBI in ICUs, which can be due to the small sample size, short study duration, the illness of patients, the influence of confounding factors such as acidosis, and use of different lettuce cultivation method.

Ischemic stroke is a severe neurological disorder that affected millions of people worldwide. Recent studies have shown that alpha-pinene has antioxidant effects during cerebral ischemia. The present study investigated the probable protective effects of alpha-pinene on brain infarction and neurological disability after a transient model of focal cerebral ischemia/reperfusion in rats.

30adult male Wistar rats whose weight ranged from 250 to 350 g were divided into five groups including a control group, a sham group, and three treatment groups. For ischemic stroke induction, the middle cerebral artery was occluded for 60 min followed by 24 hours of reperfusion. Alpha-pinene was injected intraperitoneally at the beginning of reperfusion. The neurologic outcome, infarct volume 2, 3, 5-Triphenyl tetrazolium chloride, and histological studies were done 24 hours after the end of artery occlusion.

The results showed that the application of alpha-pinene (50 and 100 mg/kg) led to a significant decrease in the infarct size as well as an improvement in neurobehavioral function. Moreover, alpha-pinene reduced the number of damaged neurons in the ischemic area.

The findings of the current study indicated that olive oil effectively reduced ischemia, promoted reperfusion, and improved neurological outcomes. Olive oil is a potent neuroprotective factor that may prevent neurodegeneration of transient focal ischemia at the beginning of reperfusion at ischemic areas.