جستجوی مقالات مرتبط با کلیدواژه "فاکتور رشد اندوتلیوم عروق" در نشریات گروه "پزشکی"

The sport exercises include a potential to prevent breast cancer. The aim of this study was assessing the prophylactic effect and adjuvant therapy of exercise on cytokines involved in angiogenesis in estrogen-dependent breast cancer.

Thirty- two female Balb/C mice were randomly assigned in 4 groups. After orientation in the environment, two groups of mice performed continuous endurance exercise for 8 weeks, and then estrogen-dependent MC4L2 cancer cells were injected to them. After that, one group of each of trained and non-trained mice performed endurance exercise 5 days per week for 6 weeks. Tumor volume was measured by a digital caliper weekly. Finally, the mice were sacrificed; tumor tissue was removed. Tumor sample was homogenized and the level of IL-6 and VEGF were measured using ELISA.

There was a significant difference in the level of IL-6 and VEGF among the groups and tumor growth (p<0.001). The level mean of IL-6 and VEGF cytokines and tumor growth in groups performing endurance exercise after malignancy (RTE and ETE) was lower than groups not performing (ETR and RTR),(P<0.05).

Due to reduction of the level of these cytokines in groups doing exercise before and after malignancy, exercise training is presumed to have adjuvant therapy in estrogen-receptor dependent tumors in addition to very effective prophylactic role.

Phytoestrogens enhance bone integrity through prevention of bone loss and stimulation of bone formation، and also facilitation of bone healing. The aim of the present study was to evaluate the effect of vitex agnus castus extract، as a source of phytoestrogen on alkaline phosphatase and VEGF (vascular endothelial growth factor) and also callus formation in women with long bone fractures. In a double-blind randomized placebo controlled trial، 32 women with long bone fracture، age 20-45 years old، were randomly divided into the VAC (vitex agnus castus)، receiving 1 Agnugol tablet (containing 4 mg dried fruit extract of vitex agnus castus) -daily for 8 weeks or a placebo group. Serum alkaline phosphatase and VEGF were measured at the beginning and the end point، and also callus formation was checked at the end of study. Serum alkaline phosphatase was increased in both groups compared to the baseline. Although the elevation of ALP (Alkaline phosphatase) in placebo group was not significant، in treatment group، ALP was considerably increased (p=. 05). Comparison of the change of VEGF showed that، only in VAC group، VEGF level was significantly increased (p=. 01). The callus formation which revealed the fracture healing، in VAC and control groups was 71. 4% and 53. 8%، respectively. Treatment with vitex agnus castus extract for 2 months could enhance the VEGF level، however، further studies are need to show the effects of vitex agnus castus extract on alkaline phosphatase level and callus formation.