جستجوی مقالات مرتبط با کلیدواژه "فیناستراید" در نشریات گروه "پزشکی"

Despite the widespread use of Bacillus Calmette-Guérin (BCG) for the treatment of superficial bladder tumors, recurrence and treatment failure is common among a significant proportion of patients..In this regard the addition of finasteride to BCG treatment may increase the effectiveness of bladder cancer treatment. The present study aimed to assess the effectiveness of finasteride in patients with bladder cancer undergoing BCG therapy

In this retrospective cohort study, 70 men with bladder cancer who were treated with BCG alone (control group, n=35) and BCG with finasteride (case group, n=35) in Shahid Beheshti Hospital in Hamadan from 2018 to 2019 were compared in terms of treatment efficacy. Data were analyzed by SPSS software (version 21) at a 95% confidence interval.

The mean duration of follow-up was 2.29±1.55 years; moreover, , the mean age scores of patients in the case and control groups were reported as 66.00±8.95 and 62.94 ±13.69 years, respectively (P=0.273). The frequency rates of recurrence of bladder cancer in patients receiving BCG with finasteride and BCG alone were obtained at 17.1% and 31.4%, respectively (P=0.163). The mean recurrence times were as 8.50 and 7.27 months in the case and control groups, respectively (P=0.404).

As evidenced by the obtained results in patients with bladder cancer, the addition of
 finasteride tablets to the BCG treatment regimen reduces the frequency and effectiveness of the disease.

Acne vulgaris is a common disorder of adolescence which may lead to significant cosmetic and psychological problems. About 70% of adolescents suffer from acne. One of the most common abnormalities that patients seek for skin care. Acne is a chronic and inflammatory disease that affects the sebaceous glands of the follicles and has a significant outbreak, especially among adolescents and young people. The objective of this randomized, double-blind clinical trial is evaluation of the effect of Finasteride microemulsion gel in the treatment of men with mild to moderate acne. In this clinical trial, 48 men with mild to moderate acne assigned into the study randomly and the subjects divided into two groups A and B randomly. Patients evaluated by a physician in terms of clinical manifestations of acne (number of lesions, acne severity, patient satisfaction). The two groups will be followed up for 3 months. Finasteride microemulsion gel twice in a day and 1% Clindamycin phosphate topical gel twice in a day will be administered for three months for group (A) and 1% Clindamycin phosphate topical gel twice in a day will be administered for three months for group (B). If any complications are detected, the patient will be excluded from the study. Then two weeks, one month, and three months after the intervention will be followed up respectively. The mean age of the patients in the case group was 22.24 ± 0.7 years with a range of 15-28 years old and in the control group 21.7 ± 0.63 years with a range of age from 30 to 16 years. The mean of total papules at the onset of treatment was 3.5 ± 3.5 in the case group and 4.1 ± 4 in the control group and there was no significant difference between the two groups. At the end of the third month, the treatment group had a mean of 0.9 ± 0.3 in the case group and 1.1 ± 0.6 in the control group and the mean difference between the two groups was statistically significant. According to the results of this study, Finasteride microemulsion gel had a good effect on the therapeutic results and it is recommended to doctors and physicians.

Drug interactions are considered as adverse effects of drugs that alter a patient’s response to an initial medication due to concurrent administration of different drugs or other substances. This study aimed to assess the role of medical education in reducing potential Atorvastatin drug interactions in a teaching hospital by distributing alert cards and putting up posters in a nursing station. Six hospital wards of Taleghani hospital were selected for the study (Gastroenterology-liver, Nephrology, Vascular Surgery, Orthopedics, Cardiology and Endocrinology Wards). The study was conducted in three phases. In the first phase, 100 patients receiving atorvastatin were examined for presence of drug interactions. Then in the second phase, warning leaflets and informative posters about atorvastatin drug interactions and its management were provided. Leaflets were distributed among ward practitioners and posters were put up in the nursing stations. Finally, in the third phase of the study, 100 patients that were being treated with atorvastatin were examined for presence of atorvastatin drug interactions. Analysis of data was performed using SPSS version 16 and p values ​​of less than 0.05were considered significant. Overall, results showed that in all six wards after training, reductions in atorvastatin drug interactions decreased from 43% to 24% and this was statistically significant (P = 0.004). The comparison between internal and surgical wards showed a significant reduction in presence of atorvastatin drug interactions only in the internal wards where it decreased from 50% to 22.5% (p <0.001). Distribution of alert cards and educational posters put up in nursing stations was successful, in that it effectively reduced atorvastatin drug interactions.

Alopecia in males isn''t disease، but is a physiological process due to body hormonal changes. Now، there are several methods for prevention and theatment of Alopecia. Minoxidil (Local) and finastride (oral) are common drugs for this problem which are overthe- counter drugs. It is necessary to Know about application of this drugs during flight with regard to critical conditions in flight and easily access to this drugs. In this article، we review the usability of these drugs for air crew during flight. In the military section: In Candia air force، Pilots are restricted to fly with or as copilot while taking these drugs. These drugs may be used by aircrew other than pilot after a 7 day grounding period to ascertain in any potential side-effects. In the civil section: FAA authorizes use of topical medications that promote hair growth (Rogaine، minoxidil) for flight duty. Oral medications such as propecia (finisteride) and procaine are allowed if there are no side effects after aground test period

Finasteride, a 4-azasteroid compound, is a specific inhibitor of type P 5α-reductase that converts testosterone into 5α-dihydrotestosterone. In the present study, the effects of human dose of finasteride on the number of spermatogenic cells, seminiferous, prostatic and epididymal tubules diameter and thickness of mature NMRI mouse were investigated, both in in vivo and in vitro conditions. In this experimental study, in in vivo condition, 18 mature NMRI mice were divided into 3 groups of 6: control (without treatment), sham (treatment whit physiologic serum) and experimental (treatment with drug). Experimental group was received intraperitoneal injection of 5 mg/kg/day finasteride for 7 days. In in vitro condition, testes, prostates and epididyms of 18 mature NMRI mice were divided into 3 groups of 6: control (fixation with bouin without treatment), sham (treatment with physiologic serum) and experimental (treatment with 5 mg/kg/day of finasteride in culture media for 3 days). Data were analyzed using one way ANOVA and Tukey test by SPSS software. P- value< 0.05 was considered significant. In in vivo condition, treatment with finasteride did not cause significant reduction in the number of spermatogenic cells, seminiferous tubules diameter compared with control group. But, in in vitro condition, significant decrease was observed. In both conditions, the drug could cause significant decrease in prostatic tubules diameter and thickness compared with control group. Diameter and thickness of epididymis tubules were decreased just in in vitro condition. Finasteride can act in long-term treatment, high doses and in in vitro condition better than other conditions.