جستجوی مقالات مرتبط با کلیدواژه "لخته خون" در نشریات گروه "پزشکی"

Bleeding agents play a vital role in preventing complications from uncontrolled bleeding, such as death and organ damage. In addition to maximum coagulation speed and minimal blood loss, these compounds should have features such as biocompatibility, degradability, hemocompatibility, suitable mechanical properties, reasonable price, and ease of use. Recent research shows that some natural polymers such as oxidized cellulose, chitosan, starch, collagen and alginate have blood clotting properties. This study has investigated the binding performance, polymer source of these materials and products available in the market.

In this research, the role of bleeding coagulation by natural polymers was investigated in 55 authentic English and Farsi articles. International and Persian publications such as Elsevier, Springer, Wiley Online Library, ScienceDirect and SID were used. Keywords and functional words such as blood clots, sodium alginate, chitosan, hemostatic, oxidized cellulose, collagen and starch were used for searching.

The first step in wound healing is ligation. Subsequent steps that contribute to tissue regeneration include inflammation, proliferation, and remodeling. These materials are divided into synthetic and natural in the world market and research works. Natural coagulant polymers include oxidized cellulose, chitosan, collagen, starch, and alginate. Next, description of natural polymers, brief introduction of synthetic polymers, physical structure of binders and commercial samples have been discussed.

The use of natural polymers as hemostatic agents shows the high potential of these substances in improving therapeutic processes and reducing the side effects caused by synthetic substances, which can lead to the development of new and effective strategies in the management of acute bleeding.

Facilitating the fracture healing process is important to increase the fracture healing speed and to decrease the time period till union. This study aimed to evaluate the effects of blood clot and doxycycline on bone healing process.

Twenty mature male New Zealand white rabbits were used, in this study. A defect was created in the middle part of the radius. The rabbits were randomly distributed into 4 groups and the gaps were filled with the graft materials: blood clot, doxycycline, combination of blood clot and doxycycline and control group in which the defect was left empty. Radiographs of operated limbs were taken on 14th, 28th, 42nd and 56th postoperative days. Histologic samples were taken on the 56th day post surgery.

On radiographic evaluation significant difference between the groups was not observed (p>0.05). On histopathological evaluation, blood clot and doxycycline groups were superior to control group (P<0.05), also combination of blood clot and doxycycline group was superior to other ones (P<0.05). There was no evidence of graft rejection in any group.

This study demonstrated that the combination of blood clot and doxycycline has a better function in bone healing process than other groups.