جستجوی مقالات مرتبط با کلیدواژه "محلول های ضدعفونی کننده" در نشریات گروه "پزشکی"

Preparing the skin for surgery with antiseptics is a standard measure to reduce surgical site infection. This study aimed to evaluate the effect of skin preparation at the surgical site with povidone-iodine 7.5% and povidone-iodine 10% antiseptics with chlorhexidine and povidone-iodine 10% on the microbial count.

This clinical trial study was performed on 80 patients with elective abdominal surgery. Patients were divided into two groups by simple random methods and proportional allocation of skin preparation with povidone-iodine 7.5% and 10% antiseptics or chlorhexidine and povidone-iodine 10% antiseptics. On the day of surgery, the culture sample was taken before the primary skin preparation, then the primary preparation was done with povidone-iodine 7.5% or chlorhexidine in alcohol, then the second culture was taken, the secondary skin preparation was done in both groups with povidone-iodine10% and then the third culture was taken. Specimens of cultures were taken on a blood agar plate and McConkey plate for the examination of microbial count and type, were immediately transferred to the laboratory.

The mean differences in microbial counts before and after skin preparation with povidone-iodine 7.5% and povidone-iodine 10% antiseptics were significant (P=0.001). Also, mean differences in microbial counts before preparation with after skin preparation with chlorhexidine in alcohol antiseptics and povidone-iodine 10% were significant (P<0.001) and in general, both antiseptic groups significantly reduced microbial counts. In comparing the effect of the two groups on the mean microbial count, although the skin preparation with chlorhexidine in alcohol and povidone-iodine 10% antiseptics was better than povidone-iodine 7.5% and povidone-iodine 10% antiseptics, the difference between the two groups was not significant (P=0.324).

Both antiseptic groups were able to significantly reduce the mean microbial counts. Therefore, it is recommended that both antiseptic groups be used to prepare skin for surgery.

Choosing appropriate disinfectants has become confusing for many dental professionals because of exaggerated manupacturer claims and misleading assays reported in the literature. Dentists should be aware of guidelines that assist in the selection of appropriate chemicals. To evaluate the level of knowledge and attitude of General Dental Practitioners (GPD) who work in private clinics in the Great Tehran in 2006 about chemical disinfectants. Methods and Materials: This study was a cross-sectional descriptive study. 446 GDPs (317 (71.1%) male, 129 (28.9%) female) were selected by a random cluster sampling method and evaluated by using a questionnaire consisting of 20 knowledge and 14 attitude questions content validity was confirmed by 4 specialists in oral medicine and 6 general practitioner. Spearman-Brown's reliability was 0.66.

The mean correct answers were 8.6 ± 3.0 (95% Cl: 8.3 to 8.9, ranged from 2 to 17) of maximum 20. Using multilinear regression formula showed that only age had negative relation with correct answers. The most difficult question was concerned with provision of and of particulars.

Knowledge level of GDPs about chemical Disinfection was low. It seems that traditional educational methods should be changed to new methods (Reform). 60.5% of the population was keep to receive. Information from programs and 46% wished to use educational leaflets.

Many studies have shown that microorganisms are the main cause of pulpal diseases and the main purpose of root canal therapy is their elimination from the root canal system. Antiseptic agents are used to reduce bacteria but their antibacterial activities differ from in vivo to in vitro studies and might be inactivated by dentin and its components in root canal space. This study was designed to investigate the effect of dentin on antibacterial activity of different antimicrobial agents. In this experimental study, two antibacterial agents (sodium hypochlorite and chlorhexidine) with different concentrations were used in four experimental groups: Group 1: dentin, Group 2: demineralized dentin with EDTA, Group 3: dentin matrix and Group 4: dentin mineral component. The species used in this study was Entrococcus faecalis. Different concentration of agents were added to mixture of each experimental group and bacteria. At the baseline and after one and 24 hours, samples were collected and cultured. After incubation period, colonies were counted. Data were analyzed by Tukey test with p<0.05 as the limit of significance. 2% and 0.2% chlorhexidine, and 5% sodium hypochlorite solutions at the three studied times eliminated Entrococcus faecalis completely. 1% sodium hypochlorite eliminated all bacteria in 1h and 24 hs. Statistical analysis showed significant differences between experimental and control groups (P<0.05). Sodium 1% hypochlorite at time 0, could reduce bacteria significantly (P<0.05) but didn’t eliminate them completely. Inactivation of intracanal antiseptics was not observed in this study. As elimination of bacteria occurred, application of these antibacterial agents are recommended in endodontic treatment. Further investigations on other antibacterial agents, other concentrations and shorter time intervals are recommended.