جستجوی مقالات مرتبط با کلیدواژه « هیپوفیز » در نشریات گروه « پزشکی »

A lot of data exists in the literature about de novo acromegaly and the results of treatment with somatostatin analogue (SSA) and primary surgery. However, in recurrent and persistent acromegaly researches are sparse. The main subject of current study is evaluation of surgery and treatment with SSA in recurrent and persistent acromegalic patients.

In this historical cohort study, the target patients were the ones referred to pituitary clinic of Sina Hospital between 2013 and 2018. Two methods of repeat surgery (as preferred option) and medical treatment with SSA were advised to patients and the treatment was finally chosen according to the patient’s will. Visual field, pituitary MRI, basal GH, IGF1, OGTT were assessed in months 3, 6 and 12 of follow-up. Finally, the rate of favorable outcome (OGTT < 1 ng/ml, without any new visual field deficit and tumor regrowth) and remission (normal GH and normal IGF1) were separately assessed.

Of 14 patients collected in surgical group (6 microadenomas and 8 macroadenomas) remission was achieved in 57% (8 cases) and favorable outcome was found in 64% (9 patients). In 16 patients of medical group remission was achieved in 62% (10 cases), while favorable outcome was seen in 25% (4 patients).

It seems that in pure monohormonal non-metastatic recurrent acromegaly with a resectable and accessible mass in imaging the preferred approach can be surgery. In high risk patients and in cases who prefer medical therapy or cases with unresectable mass medical treatment with SSA can be advised.

Endosulfan toxin is an organochlorine pesticide reduces the ability of reproductive system. In traditional medicine, herbs are used for treatment of infertility. Boswellia thurifera herb is used to treat various diseases. This study aimed to evaluate the effects of Boswellia thurifera aqueous extract on the structure of testis and sexual hormonal changes following administration of endosulfan toxin.

Forty immature male rats (aged 4-5 weeks) weighting 100-150 g, divided randomly to five equal groups. First group received only distilled water; the second group received 500 mg/kg/day Boswellia thurifera aqueous extract for 4 weeks; the third group received 10 mg/kg endosulfan pesticide for 2 weeks; and group IV and V received 10 mg/kg endosulfan pesticide for the first 2 weeks and then for 4 weeks 250 and 500 mg/kg/day aqueous extract of frankincense. The endosulfan pesticide and plant extract were administered once per each three days and daily via oral gavage, respectively. At the end of the experiment, the rats were anaesthetized with ether and blood sample was taken from the heart. Following luteinizing hormone (LH), follicle-stimulating hormone (FSH) and testosterone levels were measured. The testis were removed and stored in 10% formalin solution. The tissue samples were fixed and dehydrated with alcohol. Serial sections of 5 µm in thickness were cut using a microtome and stained using the Hematoxilin-Eosin method.

The mean seminiferous tubular diameter, germinal layer, testosterone and FSH significantly increased in group IV compared to the group II (P < 0.05). Besides, the spermatogonias cells and Sertoli and Leydig cells significantly increased in groups III and IV compared to the group II (P < 0.05).

The administration of aqueous extract of Boswellia thurifera probably decreased endosulfan effects; so that, significantly increased the activity of pituitary-testicular axis and improved the testis structure.

As an important achievement in industrialization and urbanization، depression can be much related to the oral hygiene especially periodontal indexes which are a symbol of tooth and oral hygiene and their surrounding tissues. The purpose of this study was to compare the periodontal indexes in individuals with and without depression disorders.

The present study was carried out in the form of a questionnaire، examination، and recording in the information form. The subjects were divided into two groups of 50; a group included the patients suffering from depression who hospitalized in Neuropsychology ward of Panje Azar hospital in Gorgan، Iran and the control group included either the patients who referred to department of oral medicine and diagnosis of Babol dental school or the people accompanying the patients who had claimed to have no history of depression. The periodontal indexes of the study included: Silness and Loe plaque index، Loe gingival index، pocket depth analysis، as well as bleeding on probing. The information related to each patient was recorded in the form and then two groups were compared.

In the present study، the pocket probing were 2. 7692±0. 5991 and 2. 2917±0. 4643 in the control and case groups، respectively (p= 0. 009). The Plaque Index means were 1. 5385±0. 1 and 7763. 2593±0. 5257 in the control and case groups، respectively. Furthermore، the GI and BOP difference between the two groups were not significant. Moreover، there was no significant relationship between the mean of all the analyzed indexes and the increase of depression.

The results of the present study indicate a vivid relationship between the depth of pocket probing and depression. Nevertheless، none of the periodontal indexes were obviously related to the degree of depression.