جستجوی مقالات مرتبط با کلیدواژه "کولورکتال" در نشریات گروه "پزشکی"

Prostate-specific antigen has been reported in non-prostate cancer tissues such as the breast, ovary, endometrium, kidney, adrenal, liver, salivary glands, and esophagus, as well as in colon cancer tissues. The study aimed to compare the serum level of the above antigen in women with colorectal cancer and the control group.

In this case-control study, 17 female patients with colorectal cancer and 17 healthy women who were admitted to Al-Zahra Hospital in Isfahan during 2021-2022 were selected and compared in terms of prostate-specific antigen levels.

The median free PSA level in the case group was 0.01 (0.005-0.01), and in the control group was 0.008 (0.007-0.009) (P < 0.001), and the median total PSA level in the two groups was 0.012 (0.007-0.04) and 0.001 (0.001-0.005) ng/dL, respectively (P > 0.001) and the difference between the two groups was significant.

In this study, total and free PSA levels in women with colorectal cancer were significantly higher than healthy women. Total and free PSA serum levels decreased with age, but this inverse correlation was not statistically significant. There was no significant correlation between total and free PSA serum levels and the location or stage of tumors. Measurement of PSA level in women with colorectal cancer may be helpful in the diagnosis of biopsy and applicable for early diagnosis of the disease.

Colorectal cancer is one of the most common cancers among men and women in the world. Of all the risk factors of colorectal cancer, nutritional factors are among the most important and preventable risk factors. Epidemiological studies as well as laboratory evidence have investigated the effect of omega-3 intake in the prevention of colorectal cancer, and considering the contradictory results in this area, the present study was conducted to investigate the effect of this nutrient on colorectal cancer.

In this systematic review and meta-analysis, eligible studies were carefully and independently searched by two researchers using the keywords “colorectal cancer” or “colon cancer”, “Omega 3 fatty acids”, “fish oil”, “n-3 PUFAs” and “ω-3” in ISI, PubMed, Scopus, ProQuest and Embase databases from 1993 till the end of 2017, and the search was restricted to English language. The abbreviations RR, OR, and HR were extracted with a 95% confidence interval and subjected to statistical analysis based on the random effects model.

Among 6554 articles, 15 prospective cohort studies were finally included in the research. Despite the lower rate of colorectal cancer in both genders (p=0.394, 95% CI: 0.85-1.06, RR: 0.95) as well as men (p=0.395, 95% CI: 0.79-1.09, RR: 0.93) and women (p=0.583, 0.74-1.17, 95% CI: 0.74-1.17, RR: 0.93) who consumed omega-3, no statistically significant difference was found between consumers and non-consumers.

The results of this study demonstrated that there was no significant relationship between the intake of omega-3 and its subtypes and the incidence of colorectal cancer.

Colorectal cancer can significantly cause physical, psychological and social problems. This study was done to determine the prevalence of anxiety and depression in patients with colorectal cancer in Babol located in north of Iran.
This cross-sectional, analytical study was done on 120 (75 males, 45 females) patients with colorectal cancer which registered in the Babol cancer registry in north of Iran during 2008-12. A questionnaire containing demographic information, aspects of the disease and HADS questionnaire was completed by interviewing to assess anxiety and depression for each patient.
The prevalence rate of depression and anxiety in patients was 23.4% and 30.8%, respectively. Gender, residency of rural area, and having comorbidities are related to depression among which location was identified as an independent predictor. Urban residency had 79% less risk of depression than rural residents (95% CI=0.06-0.67, OR=0.21, P The prevalence of anxiety and depression in colorectal cancer patients was high in this area. Therefore, interventions are recommended to increase awareness and greater attention to rural women and controlling comorbidities.

Colorectal cancer has a significant impact on physical، mental and social discomfort of patients. The aim of this study was to assess different aspects of health-related quality of life and its association with demographic characteristics and some clinical features in colorectal cancer survivors in the city of Babol. This cross-sectional study was conducted in 2013 among 120 colorectal cancer survivors identified in the cancer registry from 2007 to 2012. A questionnaire containing demographic data، disease characteristics and health-related quality of life (EORTC-QLQ-C30 standard questionnaire) was completed via face to face interview at patients’ homes. The mean total score of performance scale was significantly higher in men (69/24± 16/71) than in women (57/67 ± 17/87) (P=0. 001). Men obtained higher scores in all 5 performance scales which was statistically significant in the domains of physical، emotional and cognitive performance. Among the demographic variables، comorbidities، education and employment were identified as the independent predictors of quality of life. The patients had an average quality of life which was associated with employment، education and comorbidities. Therefore،، empowering the health staff، increasing the awareness of patients and their families as well as better management of comorbidities can help the patients to return to an active life.

Background and Colorectal cancer is the fourth most common cancer in Iran. The incidence of this cancer, especially in the northern regions in Iran, has increased in the last two decades. This study was designed to update the demographic and clinical characteristics of patients with colorectal cancer in Mazandaran province. All patients with diagnosis of colorectal cancer who were treated during 2008-2014 in Imam Khomeini Educational Hospital and Touba polyclinic (a university affiliated center) were included. We evaluated the age, sex, location of tumor, stage of tumor, presence of metastasis, location of metastasis, and clinical symptoms. Three hundred and sixty four patients, including 53.4% male and 46.6% female, were examisned. Almost one-third (31.3%) of patients were younger than 50 years of age and there was no significant difference in the mean age of both sexes (p=0.42). At time of diagnosis, 37.2% of patients were in stage 4. Family history of cancer was positive in 45%, and this rate increased to 63.9% in cases younger than 50. The mean age of patients with positive family history was lower compared to those with negative family history (P=0.028). The mean age of colorectal cancer in studied patients, especially those with positive family history, was lower compared to what have been found in similar studies. The majority of patients were in advanced stages at the time of diagnosis. These findings call for more attention to the initial sign and symptoms of colorectal cancer and carrying out screening programs for early diagnosis and treatment.

Colorectal cancer is the fourth most common cancer in Iran with a diverse geographic distribution. The purpose of this study was to determine the incidence of colorectal cancer and assess the clinical and epidemiologic characteristics of survivors in the city of Babol، Iran.

In this cross-sectional study، all new cases of colorectal cancer، recorded by the Cancer Registry Center of Babol، were included for the assessment of the incidence of colorectal cancer during 2007-2012. Clinical and epidemiologic features of patients were investigated via interview in 2013.

A total of 237 patients were registered during the specified period، although only 120 subjects had survived until 2013. Age-standardized rate was 7. 7 per 100،000 people in 2007، which increased to 14. 6 in 2012. Overall، 54% of subjects were urban residents، 46% were illiterate، 30% were smokers، 16% used hookah، and 10% consumed opium. Family history of colorectal cancer was reported in 27 patients (22. 5%). The average age of survivors was 56. 74±14. 14 years; about a third of patients were younger than 50 years at the time of diagnosis. The mean interval between the presentation of symptoms and diagnosis was 10±13. 3 months، and the most common symptoms of the disease included altered bowel habits، rectorhalgia، abdominal pain، constipation، and weight loss، respectively.

The obtained results showed the increased incidence of colorectal cancer in Babol city. Considering the significant number of young people and the long interval between the onset of symptoms and definitive diagnosis، it is recommended that training courses on the warning signs and screening of colorectal cancer be planned.

Cancer is the third cause of death in Iran. Gender is an important covariate for incidence of most cancers. So، epidemiological data on Gender differences related to common cancers provide good evidence in control of cancers. The aim of this study was providing population-based information on the gender differences in incidence rates and epidemiology of esophagus، stomach، colon and rectum cancers in the Fars province.

This study was a secondary data analysis. We studied registered esophagus، stomach، colon and rectum cancers cases in Fars from 2009 to 2010. Direct Annual Age Standardized Incidence Rates (AASIRs) were estimated for men and women. Using STATA software، Females AASIRs and truncated AASIRs at 25 years (TIRR) were compared with males considering age، dominant morphology ratio and tumor grade.

Six hundered fourteen cases were studied. The numbers of registered esophagus، stomach، colon and rectum cancers were 78 (%12. 7)، 254 (%41. 4)، 182 (%29. 6) and 100 (%16. 3)، respectively. Two hundred thirty one (%37. 5) cases were women and 383 (%62. 5) were males. TIRR (female/male) for esophagus، stomach، colon and rectum cancers were 0. 68 (0. 43-1. 07)، 0. 42 (0. 32-0. 54)، 0. 71 (0. 53-0. 96)، 0. 92 (0. 62-1. 36)، respectively. There were significant relationships between age and gender (p=0. 046)، tumor grade (p=0. 050) and morphology (p=0. 004) in case of stomach cancer. For colon cancer age and tumor morphology were significantly related (p=0. 019).

Risk of Stomach and Colon cancers in females were lower than males in Fars Province. Male gender was a risk factor for stomach adenocarcinoma.

Colorectal cancer is one of the most common cancers worldwide including 38% of gastrointestinal cancers. Colorectal cancer is the third type of Iranian men and fourth in women in ranking. The purpose of this study was to determine the role of environmental risk factors in colorectal cancer. In this case-control study, the authors selected cases from colorectal cancer patients in Arak and controls were selected from Arak hospitals in proportion to the number of cases. Data collected by using a structured questionnaire and based on interviews with patients and their medical records. We used chi-squared and independent t-tests to analyze data. Logistic regression applies to eliminate the effect of possible confounding variables. From all participants 55.7% were male and 90% got married. 33.6% were overweight and/or obese. Mean ± SD of age and BMI was 54.41±14.88 yr and 24.42±4.58, respectively. Regression model showed that fatty food intake, high education and positive family history are the predictor risk factors of colorectal cancer. Due to preventable colorectal cancer and increased global incidence of disease, educational intervention about the importance of disease, methods of screening and diagnosis, treatment and rehabilitation of patients are necessary.

Colorectal cancer is the third most common cancer and the third leading cause of cancer death. Most often it is derived from an adenomatous polyp. Therefore, detection and treatment of these baseline polyps could potentially decrease the prevalence and incidence of colorectal cancers. One of these screening procedures is colonoscopy, which is more Precise than others like. Barium enema in detecting primitive and small polyps. In addition, colonoscopy has the added benefit that lesion can be removed during the same procedure. Thus, this study was performed to determine the frequency of polyps and colorectal tumors among patients who underwent colonoscopy in Shariati hospital between November 2000 and November 2002. Patients and This retrospective analytical cross-sectional study was performed on 993 patients who underwent colonoscopy in Shariati hospital from November 2000 to November 2002. Method of sampling was by census. All patients were evaluated for demographic variables, location and size of polyps and tumors by using a checklist. The data were collected, described and analyzed using SPSS V.11.5 sofware. Chi2 and Student t-test were performed in the data analysis. Among 993 patients who were studied, 529 (53.3%) were males and 464 (46.7%) were females. The frequency of polyps and tumors in this study was 15.4% (153 of 993) and 4.8% (48 of 993), respectively. There was a significant association between the frequency of polyps and its location (P<0.01). The most common location of polyps was sigmoid (76.5%). Also, a significant association was observed between the frequency of tumors and its location (P<0.01). The most common location of tumors was again recto-sigmoid colon (70.8%). Additionally, polyps and tumors were respectively 1.6 and 1.7 times more prevalent in men than women. Regarding the most prevalent location of polyps and tumors, the use of fexible sigmoidoscopy may lead to detection and even treatment of many accessible polyps and tumors which could result in prevention of many colorectal cancers. Also colonoscopy is useful to detect lesions which were not detected by sigmoidoscopy and these inaccessible polyps and tumors can be bilopsied.

Introduction & At the present, cancer is the third factor in mortality and constitutes. The second grand of non-transmitted chronic disease. The colorectal cancer is among the most important kind of cancer through out the world. It is the most prevalent cancer of the gastrointestinal system. It constitutes about 70% of the mortality due to cancer. In this project we have made an epidemiologic study of colorectal cancer in Arak for a period of ten years. In this descriptive study, the documents of 274 patients with colorectal cancer hospitallized in Vali Asr, Imam Khomeini and Ghods hospital in Arak during 1994-2004 were evaluated. The extracted data consisted of age, sex, stage of disease with, type of cancer, the primary symptom at the time of referring time were analyzed by SPSS software. There were 54.7% men and 45.3% women. The mean age of the patient's age was 56.22 and 17.5 percent of them were less than 40 years old. Most patients were in the third stage of cancer at the diagnosis time and the most prevalent type of the cancer has been adenocarcinoma. The most prevalent region of anatomic lesion was rectum. Rectorrhagia was reported to be the most prevalent symptom at the first referral. Considering the high frequency of the patients with age less than 40 years and the youthfulness of the society genetic problems and environmental risk factors should be considered. Assessment of risk factors and the isolation of patients should be done at the earlier stage. Considering the high frequency of rectosigmoid tumors in our study, it seems that fiberoptic sigmoidoscopy method has important role in the early diagnosis and treatment of these patients in Iran.