جستجوی مقالات مرتبط با کلیدواژه "گرانولوم" در نشریات گروه "پزشکی"

Granuloma is a delayed type hypersensitivity reaction in response to foreign material. It is manifested by the organized accumulation of mature mononuclear macrophages. Sometimes granuloma may be formed in the absence of external factors. In addition to infectious agents, autoimmune diseases and primary immune deficiencies can cause granuloma. A number of primary immune deficiencies can cause autoimmune disorders and granulomatous inflammation, so these people in addition to frequent infections suffer from non-infectious complications that can have an important effect on prognosis. In this review, we intended to have an overview of primary immunodeficiency diseases with granulomatous inflammation and evaluate the effects of these lesions on the prognosis and course of the disease. Article search was performed by Scopus, Web of Science, and Google Scholar databases. We tried to use the latest and most reliable articles in English and Persian language that are related to our topic. The best articles were selected as references after evaluation of the journal and methodology of the paper. .

Timely diagnosis and treatment of inflammatory conditions, which sometimes appear before infectious manifestations, will be effective in improving the prognosis of the disease. The treatment of these patients with immunosuppressive drugs and corticosteroids should be based on several factors such as: patient's condition, severity of granulomatous inflammation, and presence of active fungal or bacterial infection.

One of the most important pathologies of tattooing is granulomatous reaction to the tattoo which is usually represented by symptoms like pain, inflation, redness and tenderness at the tattoo area. Granulomatous reaction to tattoo occurs at all ages and has been seen among both male and female. Due to the new rise in popularity of cosmetic tattoos and its pathologies, we intend to explore a descriptive study of the demographic and histopathologic characteristics of the granulomatous reactions due to cosmetic tattoos.

Razi hospital patients with proven tattoo granuloma pathology in a 3-year period were identified and studied and their demographic-histological characteristics were recorded. The study is of a cross-sectional type. 196 patients were enrolled in the study, a questionnaire was prepared for each patient and information was collected through them. 

The mean ± standard deviation age of the patients was 45.46±8.54. The mean ± standard deviation tattoo time was 4.18±4.33. The mean ± standard deviation frequency of tattooing was 1.64±1.8. The most common tattoo area was eyebrow in 88.3% of the patients and least common was upper eyelid in 0.6%. The most common pathology result was tattoo granuloma in 41.7% of the patients and the least common was Lichenoid in 2.8%.

Considering the highest frequency of pathological diagnosis of tattoo-granuloma (Sarcoidal and foreign body) with 41.7% in our study and observing the relationship between tattoo-granuloma and sarcoidosis in previous studies, complete examination of patients, long-term follow-up of patients which will have sarcoidosis in the future and examining the clinical response to treatment seems logical and beneficial. It is also important to consider whether the treatment of current lesions will play a role in preventing sarcoidosis in the future or not.

To report a rare presentation of ophthalmic tuberculosis.

 A 19-year-old man was referred to the glaucoma clinic due to multiple attacks of increased intraocular pressure (IOP) in his right eye. IOP of the right eye was 50 mmHg, and glaucomatous damage of the optic nerve was present. In gonioscopy, an oval-black lesion was present in the ciliary body band on the temporal side, which looked like a granuloma in ultrasound biomicroscopy (UBM). After rejecting immunological diseases due to the 20mm tuberculin test, the diagnosis of ciliary body tuberculosis was made. The patient was treated with a multi-drug regimen for 9 months. After 4 weeks, IOP was normalized, and at the end of 9 months, the ciliary body granuloma disappeared.

Ciliary body tuberculosis can cause multiple attacks of acute IOP rise (possibly due to the release of pigment and necrotic debris). Systemic causes of glaucoma such as tuberculosis should be kept in mind, especially in unilateral cases, and performing a thorough gonioscopy is useful in this regard.