جستجوی مقالات مرتبط با کلیدواژه « گیاه خرفه » در نشریات گروه « پزشکی »

Due to the importance of investigating nosocomial infections and drug resistance in bacteria causing these infections, the use of herbs can be very helpful in treatment. In the present study, the effect of silver nanoparticles obtained from portulaca oleracea extract on bacteria causing nosocomial infections and effective parameters in the synthesis of these nanoparticles were investigated.

First, an aqueous extract of portulaca oleracea was added to a 1 mM silver nitrate solution. The extract was used as a reducing and stabilizing agent for nanoparticles. The effect of effective parameters for the optimization of silver nanoparticles was evaluated by ultraviolet-visible spectroscopy and transmission electron microscopy. The antioxidant and antibacterial effect of the synthesized nanoparticles was determined by studying the activity of catalase, MIC, MBC, disk, and well method.

The results showed the effect of alkaline pH as well as silver salt concentration on the quality of synthesized nanoparticles. Also, the results of the antimicrobial test showed that gram-negative bacteria revealed significant sensitivity to synthetic nanoparticles and Staphylococcus aureus showed the highest resistance to nanoparticles. Antioxidant properties were also observed against gram-negative strains.

The results showed that silver nanoparticles synthesized with portulaca oleracea had antibacterial and antioxidant properties. Therefore, photosynthesis of nanoparticles can be a good option for the treatment of infectious diseases caused by gram-negative bacteria.

Portulaca Oleracea is a medicinal plant with many effects including analgesic and anti-inflammatory properties. This study aimed to investigate the effect of alcoholic extract of Portulaca Olerecea on CCI model of neuropathic pain (Bennet & Xie model) and acute thermal pain induced by Tail Flick. Adult male Wistar rats weighing 200-250 g were used. Sensitivity to mechanical stimuli (mechanical allodynia) and noxious thermal stimuli were evaluated by Von Frey filaments and Tail Flick, respectively. In neuropathic pain studies, animals were randomly assigned to five groups of sham, CCI, two groups subjected to CCI and injected with extract (200 and 400 mg/kg, i.p.) and a group subjected to CCI and injected with normal saline. In these groups, mechanical allodynia was assessed on day 7 after surgery. In acute pain studies, animals were divided to three groups of a group that received normal saline and two groups that received extract (200 and 400 mg/kg, i.p.). In these groups, Tail Flick was measured 30 minutes after normal saline or extract administration. Data were analyzed by SPSS and appropriate statistical tests. All of the rats that had experienced CCI, exhibited mechanical allodynia after neuropathy.Portulaca oleracea could reduce the development of mechanical allodynia after CCI at 200 and 400 mg/kg doses. Thermal acute pain was reduced by 400 mg/kg of the extract. Our findings indicate that Portulaca Oleracea extract can reduce behavioral symptoms of
neuropathic and acute pain.

The injuries of peripheral nervous system cause the death of a number of motor cells of the spinal cord. Neurotrophins family genes such as NT3 involve in neuronal survive after nerve injury and their expression changes after it. With due attention to the expansion of portulaca pleracea in the world study was conducted to determine the effects of alcoholic and aqueous extracts of Potulaca oleracea on the NT3 gene expression after sciatic nerve compression in rat.
This study was performed on 88 male wistar rats that randomly were divided in 13 groups of 6 each. They consisted of control group, 4 compression groups (The sciatic nerve was compressed with locker pincer) and 8 treatment groups: compression treatment with dose of 75 mg/kg of alcoholic and aqueous extract of Portulaca oleracea on days 1 and 7 (never compression was done on the first day). In all groups, Total RNA was extracted from the lumbar spinal cord segment in 1, 7, 14, 28 days and cDNA was synthesized, then NT3 expression changes were compared in groups.
There was a significant increase in NT3 gene expression in the compression group compared to control (p The results reveal the Portulaca oleracea leaves extracts increase the NT3 gene expression after sciatic nerve injury. This effect is more in alcoholic extract than aqueous extract.

Thyroid hormones have a key role in regulation of metabolism and function of the tissues. This study was carried out to evaluate the effect of alcoholic extract of Portulaca Oleracea on serum level of thyroid hormones in hypercholestrolemic rats. In this experimental study, 60 adult male Wistar rats were randomly allocated into six groups including: control group with normal diet, fat diet group with high fat diet and interventional groups were received high fat diet and alcoholic extract of Portulaca Oleracea with maximum dose (800 mg/kg/bw), moderate dose (400 mg/kg/bw), minimum dose (200 mg/kg/bw) intraperitoneally for 21 days and finally, animals in atorvastatin group were received high fat diet with atorvastatin (10 mg/kg/bw, intraperitoneally) for 21 days. After the end of this period, T3, T4, TSH and total cholesterol measured for each animal. Serum level of T3 and T4 in the experimental groups which were received Portulaca Oleracea extract and atorvastatin group significantly increased in compared to controls (P<0.05). Serum level of TSH level significantly reduced in the experimental groups which were received Portulaca Oleracea extract and atorvastatin group in compared to controls (P<0.05). The serum total cholesterol level significantly reduced in the experimental groups which were received Portulaca Oleracea extract and atorvastatin group in compared to fat diet group (P<0.05). Portulaca Oleracea extract with increasing of secretion of thyroid hormone reduced the total cholesterol and TSH animals with hypercholesterolemia.

Hyperlipidemia can be cause a variety of diseases such as atherosclerosis, diabetes and fatty liver and subsequent liver enzyme increases. The Portulaca Oleracea plant has hypoglycemic and hypolipidemic properties. Therefore, in this study the effect of Portulca Oleracea herb extract on serum liver enzymes including aspartate aminotransferase (SGOT or AST), alanine aminotransferase (SGPT or ALT) and alkaline phosphatase (ALP) in rats were studied. In this experimental study, 60 Wistar rats were divided into 6 groups (n=10). Control group with normal diet, fat diet group and other groups, the experimental group received the same diet plus fat Portulaca oleracea extract maximum dose (800), the mean dose of (400), and a minimum dose of (200 mg / kg) or intraperitoneally injection (ip) and sort of Atorvastatin (10 mg kg). After the end of this period (21 days), blood sampling was performed and collected data were analyzed using the t and Tukey test, and SPSS software version 11.5. Comparison of statistical results indicated that alanine aminotransferase (ALT) and Alkaline phosphatase (ALP) increase in the control group that received only fatty foods, while the experimental groups received extract of Portulaca Oleracea, and groups receiving Atorvastatin had reduced levels of liver enzymes. Regarding hypoglycemic and hypolipidemic antioxidant activity of the extract and its effect on reducing liver enzymes, plant extracts can be recommended to improve liver function.

Imbalance Between antioxidant defensive system and increased production of free radicals leads to oxidative stress that can be effective in making cellular damage and causing some diseases such as diabetes. The aim of the current study was to investigate the effect of eight-week purslane extract consumption on some peroxidant and antioxidants indicators in patients with type 2 diabetes. The Participants were 16 women with type 2 diabetes who had not the history of once a week regular physical activity program, in previous five years. They were randomly divided into two groups of experimental, purslane supplementation for eight weeks, and control. Blood sampling was performed in two stages. After eight weeks of purslane consumption, resting levels of MDA, SOD and CAT in Supplementation group showed a significant decrease compared to those of control group. Purslane consumption can improve peroxidant/antioxidant balance in women with type2 diabetes.

Purslane (Portulaca oleracea) has positive effects on total cholesterol reduction and has different effects on nerves system، thus it might affect pituitary-gonadal axis. This study aims to test the probable effects of hydroalcoholic extract of purslane on gonadotropins، estradiol، progesterone and prolactin hormones. In this experimental study، 40 adult virgin female Vistar rats strain weighing 189±2gr were divided in five groups of eights. The control group without any drug application، the sham groups received 0. 2 ml distilled water as solvent and the experimental groups 1، 2 and 3 orally received 200، 400 and 800 mg/kgBW of hydroalcoholic extract of purslane for 21 days. At the end of the period of 21 days، the blood test was taken and the amount of hormones in their blood was tested. The data were analyzed using one away ANOVA. The findings of the study indicated a significant reduction (P<0. 05) in the amount of estradiol in experimental group 3 and a reduction in the body weight in experimental group 2 compare with the both control and sham groups. No significant difference was observed in LH، FSH، progesterone and prolactin. The results indicate the dose –dependant effect of purslane in weight loss over 21 days. In addition، due to the anti-estrogenic and anti-aromatase compounds in purslane، it reduce the concentration estradiol is in the maximum dose. Thus، a prolonged application of purslane may lead to hormone disorders and a reduction in fertility.