جستجوی مقالات مرتبط با کلیدواژه "alcoholic liver diseases" در نشریات گروه "پزشکی"

Food derived antioxidants have a special property for long term use as chemopreventive factor in disease states such as alcoholic liver diseases and hepatitis. This research decided to assess the property of several Eruca sativa Mill extract in ethanol induced liver injury in animals.

30 rats were divided into four groups included treatment groups with E. Sativa extracts (Water and methanolic), prophylactic and control. Oxidants/antioxidants profile, lipid profile, and serum liver functions tests were done.

The finding revealed that extracts of E. Sativa decrease the alcoholic liver injury. In addition, the extracts of E. sativa may exert their prophylactic and cure role against ethanol oxidative stress by enhancing the antioxidant enzymes and antioxidant molecules levels.

Totally, this research proofed that the E. sativa leaves water extract is better than methanolic extract in decreasing alcoholic liver injury.

Alcoholic liver disease (ALD) is the main cause of chronic liver disease across the world and can lead to fibrosis and cirrhosis. The etiopathogenesis of ALD is related to ethanol-induced oxidative stress, glutathione reduction, abnormal methionine metabolism, malnutrition, and production of endotoxins that activate Kupffer cells. Curcumin is an active ingredient of the rhizome of turmeric. The substance is shown to have minor adverse effects. As the substance possess low bioavailability in free formulation, different strategies has been conducted to improve its bioavailability which resulted in production of nanomiscels and nanoparticles. Curcumin can provide protection for the liver against toxic effects of alcohol use. Several studies showed curcumin blocks endotoxin-mediated activation of NF-κB and suppresses the expression of cytokines, chemokines, COX-2, and iNOS in Kupffer cells. According to the molecular studies, curcumin inhibits NF-κB signaling pathway, regulates cytokines production and modulates immune response. It has been shown that curcumin can suppress gene expression, especially cytokines genes resulting in down-regulation of tumor necrosis factor-α (TNF-α), interleukin 1 (IL-1), IL-6, IL-8, adhesion molecules (ICAM, VCAM) and C-reactive protein. Hence, curcumin can have therapeutic effects on the majority of chronic inflammatory diseases such as asthma, bronchitis, inflammatory bowel disease, rheumatoid arthritis, ALD, fatty liver, and allergy.