جستجوی مقالات مرتبط با کلیدواژه « aloe vera gel » در نشریات گروه « پزشکی »

Diabetics usually suffer from chronic complications, including microvascular and macrovascular disorders. The capillaries supplying the sexual organs affect normal sexual functions. The erectile process has been shown to be impaired in diabetics. Vascular damage in diabetics may be associated with decreased testosterone production, sperm count, testicular weight, and seminiferous tubule diameter. In this study, we investigated the effects of Aloe vera gel extract (from Sistan and Baluchistan, Iran) on the male genital system in streptozocininduced diabetic rats.

A total of 24 male Wistar rats were included in the study. Diabetes was induced in 12 rats by intraperitoneal injection of a single dose of streptozotocin (STZ). The rats were divided into four groups. The first and third groups received saline (NaCl) by gavage daily. The second and fourth groups received Aloe vera gel extract daily by gavage. Treatments were continued for 30 days. At the end of the treatment period, blood samples were taken and serum glucose and testosterone levels were measured by photometric methods. Histological examinations were performed on the prostate and testes.

Mean weight index, serum levels of glucose and testosterone, mean sperm count, germinal epithelium (GE) thickness, and seminiferous tubule diameter improved significantly in the diabetes + Aloe vera group.

We concluded that consumption of Aloe vera gel extract improved sexual complications in diabetic rats.

Although several studies have highlighted the beneficial effects of Aloe vera on burn wounds, limited clinical evidence exists in this regard. This study aimed to evaluate the impact of the Aloe vera gel on healing, itching and pain of burn patients.

This clinical trial was conducted at Sina Hospital in Tabriz, Iran. The patients with second and first degree burn wounds on symmetrical organs, were randomly assigned to control (n=34) and experimental (n=34) groups. The Aloe vera gel and silver sulfadiazine cream were used in the experimental and control groups, respectively. To assess the healing effects, the Bates-Jensen Wound Assessment Tool (BWAT) was employed. Regarding itching and pain, visual analogue scale (VAS) was used for precise evaluation and comparison on days 1, 3, 5, 7, 9 and 14. The data were analyzed using SPSS version 13.

Although the wounds in both groups healed up completely within two weeks, the healing process among the patients in the experimental group was faster. The peak of wound itching was on day 7 in both groups. The wound itching significantly reduced half an hour after being dressed with Aloe vera gel. The wound pain in the experimental group was less than control group during the study period. Moreover, there was no pain in either experimental or control group on day 14.

Aloe vera is an effective agent in reducing itching and pain, and it can substantially increase the rate of healing. Accordingly, this agent can be considered in the treatment of burn wounds.

One of the most common problems in the intensive care units (ICUs) is pressure ulcers (PUs). The present study aimed to evaluate the effectiveness of aloe vera gel, olive oil, and compound aloe vera gel‑olive oil in the prevention of PUs.

This randomized clinical trial was conducted on 240 patients. They were randomly divided into four groups, aloe vera gel (n = 60), olive oil (n = 60), aloe vera gel‑olive oil combination (n = 60), and control (n = 60). Braden scale and National Pressure Ulcer Advisory Panel scale were used to collect data. The intervention was performed for 30 days. In the intervention and control groups, the patient received routine care. In each intervention group, 10–15 ml of olive oil or aloe vera gel or a combination of olive oil and aloe vera was rubbed into body areas under pressure.

There were no PUs detected in all groups before the intervention; after the intervention, 12 patients in the olive group, 20 patients in the aloe vera group, 10 patients in the aloe vera‑olive combination group, and 22 patients in the control group developed PUs. The results reported 40% of the patients with stage 1 PU and 10% of them with stage 2.

Due to the effectiveness of olive oil and aloe vera‑olive oil combination in preventing PU, it is recommended to use these herbal compounds in preventing PU on ICU patients.

Nowadays biomaterial has been proposed as a suitable alternative for chemical substance. It has no odor and taste and its consumption is beneficial to human health. The present study aimed to investigate the effect of application of chitosan coating individuality and along with Aloe Vera gel on the nutritional level and quality of strawberry fruit (cv. Camarosa).

After application treatments Aloe Vera gel (0, 50 and 100%), Chitosan (0, 0.5 and 1%) and their combination, plates contain strawberry were kept in the refrigerator with a temperature of 4 ± 1 °C, at humidity of 85- 90%. Traits were evaluated in the first days zero, 4, 8 and 12.

The results showed fresh weight of fruit, chlorophyll, vitamin C and anthocyanin significantly affect by Aloe Vera 100%+ Chitosan 0.5% application. Also, plants treated with Aloe Vera 50% + chitosan 0.5% produced higher taste index, phenol and antioxidant capacity. On the other hand, lower weight loss of fruit, malondialdehyde and total soluble solids was observed with Aloe Vera 100 % + Chitosan 0.5 %. Storage life significantly was enhanced with Aloe Vera 50% + Chitosan 0.5% up to 15.7 days which was the same level with Aloe Vera 100% + Chitosan 0.5%.

Overall, the application of Aloe Vera treatment 50% or 100% along with Chitosan 0.5%, would be a highly recommended practice in the maintaining the nutrition value and storage life of strawberry fruits.

Routine treatment of burn injuries is dressing with Nitrofurazone ointment. It has several complications including sensitivity. Aloe vera is a traditional treatment for wound healing.  This study aimed to compare the effectiveness of Aloe Vera gel with Nitrofurazone ointment in the healing of superficial partial-thickness burns.

Methods & Materials: 

The present study was a split body controlled clinical trial which was carried out on 30 patients with superficial partial-thickness burns. The study was conducted in the Shafa Hospital in Kerman, Iran in 2016. The sample was recruited from patients who had at least two burns, each burn on an alternate side of the body. Samples were allocated to two groups that received Aloe Vera gel or 2% Nitrofurazone ointment on their burns. Bates-Jensen Wound assessment tool was used to evaluate the healing of burns. Statistical analysis was conducted by SPSS-16 and using the repeated measure ANOVA.

The repeated measure ANOVA showed that there was a significant change in the score of BWAT in all areas during the intervention period ( p=0.001), but The trend of healing in the two groups during the intervention period was not significantly different( p=0.098).

Based on this study it looks like Aloe vera gel is as effective as  2% Nitrofurazon ointment in healing wounds.

Use of aloe vera gel in dairy industries is important for increasing quality of dairy products. In the present study, effects of aloe vera gel with inulin and whey powder on survival of probiotic bacteria, rheological and sensory characteristics of yogurt were investigated.

Low-fat (1.5%) probiotic yogurts were prepared from pasteurized milks, 1% of starters and 2% combinations of Lactobacillus acidophilus with Bifidobacterium animalis at 40 °C and pH 4.4. Probiotic yogurts mixed with aloe vera gels at 0, 5, 10, 15 and 20% were stored seven days at 4 oC. Since the probiotic yogurt with 10% of aloe vera gel included the best sensory scores compared to other aloe vera gel concentrations after seven days of storage at 4 oC, this formulation was mixed with inulin at 0.5, 1 and 1.5% (w/w) or whey powder at 5, 10 and 15% (w/w). 

Sensory evaluations showed that the probiotic yogurt with 10% of aloe vera gel and 1.5% of inulin included the highest scores of flavor, texture, aroma, color and acceptance within the samples after similar storage conditions. The probiotic yogurt with 10% of aloe vera gel and 1.5% of inulin included the highest survival of Lactobacillus acidophilus and Bifidobacterium animalis, while controls (with no aloe vera gels) showed the lowest survival rates of Lactobacillus acidophilus and Bifidobacterium animalis. Apparent viscosity and serum separation of probiotic yogurt with 10% of aloe vera gel and 1.5% of inulin respectively increased three times and decreased to less than 4%, compared to controls and whey samples at similar shear rates and storage times.The pH decrease of probiotic yogurt with 10% of aloe vera gel and 1.5% of inulin was much slower than those of the control and whey samples during storage, including no serum separations during storage.

Aloe vera gel and inulin improved viability of probiotic bacteria and quality of yogurt samples during storage.

Aloe vera is used for its large variety of biological activities such as wound healing, anti-fungal, anti-inflammatory, hypoglycemic, immunomodulatory, gastroprotective, and anti-cancer. Although the beneficial effects of Aloe vera on wound healing have been proven, little is known about its effects at the cellular level. In this study, we evaluated the angiogenic and migrative effects of Aloe vera gel on fibroblasts and endothelial cells. Fibroblasts and endothelial cells were cultured in monolayer conditions with low glucose DMEM with 10% serum and 1% penicillin-streptomycin. Fresh and mature leaves of Aloe vera were used for gel preparation. Cell proliferation and morphology were studied by an inverted microscope. The migration of fibroblasts was assessed by scratch assay. MTT assay was performed for cell viability assessment, and real-time RT-PCR was used for evaluation of PECAM-1, integrin α1 and β1 transcription. After two days, the protein level of PECAM-1 was detected by flow cytometry. Our results showed that Aloe vera has a higher proliferative effect on fibroblasts in comparison with endothelial cells. Aloe vera also induced the migration of fibroblasts. The viability of both types of cells was similar to control ones. Integrin α1, β1 and PECAM-1 gene expression increased significantly (P < 0.005) in Aloe vera treated fibroblasts and endothelial cells in comparison with the control groups. However, the expression of these genes was significantly higher in fibroblasts in compareison with endothelial cells. Protein levels of PECAM-1 showed no change in both cell types upon Aloe vera treatment. Aloe vera gel induced angiogenic and cell adhesion properties in fibroblasts more than endothelial cells. Further investigations are needed to show the main role of fibroblasts rather than endothelial cells in wound healing by Aloe vera administration.

The use of herbal and synthetic compounds can be effective in improving the areas and repair of tissues that have been affected during the processes like what happens in ulcerative colitis (UC) as a common inflammatory disorder. According to the beneficial effects of aloe vera, in this study, we aimed to assess the therapeutic effects of oral aloe vera gel on acetic acid-induced colitis in rats by histopathological and molecular analysis of Bax, and BCL-2 genes expression (using RT-PCR technique) in colon tissue samples.

This experimental study comprised 32 adult male Sprague Dawley rats weighting 220 ± 20 g that were randomly divided into four groups as follows. The control group (healthy rats), colitis group in which UC was induced by transrectal administration of 3% acetic acid with no treatment, oral form of sulfasalazine group in which UC was induced by transrectal administration of 3% acetic acid, then was treated by oral administration of sulfasalazine 500 mg/kg body weight, and the fourth group which received oral form of aloe vera gel (200 mg / kg) for 21 days, respectively after induction of UC. Then, the therapeutic effects of treatment groups were compared with the control group and the colitis group with no treatment, by the assessment of histopathological and molecular changes in the colon tissues of rats on the 7th, 14th, and 21st days. Finally, the collected data were analyzed using statistical tests.

 Histologically, aloe vera gel treatment could reduce and heal colon tissue damages in induced colitis. Also, this gel reduced apoptosis in rat’s colon with acetic acid-induced colitis, which showed in significantly decreased in Bax mRNA expression and significantly increased BCL-2 mRNA expression compared with the colitis group with no treatment.

Aloe vera gel has a significant effect on the treatment of UC in rat because of the beneficial effect that was found from aloe vera such as decreasing the severity of colitis as evidenced by histopathological findings, and with respect to apoptosis and gene expression that were related to wound healing process, and suppression of the elevation of Bax mRNA with the upregulation of Bcl-2, which can be considered effective in the treatment of UC.

Natural biomaterials are a key base in tissue engineering, and collagen, as the maincontent of the extracellular matrix (ECM), is frequently used in tissue engineering. Aloe verahas some therapeutic effects on ulcers, therefore, the use of this natural resource has alwaysbeen considered for improving collagen function. We aimed to evaluate the effect of Aloe vera/Collagen blended on cell viability, cell attachment, and angiogenic potential by determining ofintegrin α1β1 and platelet endothelial cell adhesion molecule (PECAM-1) genes expression inhuman adipose-derived stem cells (hASCs).

In this study, hASCs after harvesting of adipose tissues from abdominal subcutaneousadipose tissue and isolation, were cultured in four groups of control, collagen gel, Aloe veragel, and Aloe vera/collagen blended in vitro environment at 24h and then cell viability wasassessed by MTT (3-(4,5-dimethylthiazol 2-yl)-2,5-diphenyltetrazolium) assay. Integrin α1β1 andPECAM-1 genes expression were evaluated by real-time RT-PCR.

The results of MTT showed that the combination of Aloe vera/collagen was retained thecell viability at the normal range and improved it. In real-time RT-PCR results, integrin α1β1 andPECAM-1 gene expression were increased in the Aloe vera/collagen blended group comparedto the control group.

For tissue engineering purposes, Aloe vera improves collagen properties in theculture of hASCs by increasing the expression of the integrin α1β1 and PECAM-1 genes.