جستجوی مقالات مرتبط با کلیدواژه "anti-anxiety agents" در نشریات گروه "پزشکی"

Linalool is one of the active monoterpene alcohols found in many plants, such as lavender, rosemary, and jasmine. This compound has anti-inflammatory, antibacterial, and antimicrobial properties and is a popular aromatic compound in cosmetics and health industries. Linalool has two optical isomers, R and S, with different aroma profiles. Recently, many studies have been conducted on the effects of linalool on the central nervous system, which has shown that this compound can positively affect brain function. Numerous studies have demonstrated that linalool possesses neuroprotective, anti-inflammatory, and antioxidant properties. Furthermore, it demonstrates sedative, anti-anxiety, antidepressant, anticonvulsant, analgesic, and anti-Alzheimer's effects.

Linalool holds promise as a natural compound for enhancing cognitive performance and supporting brain health. However, further research is needed to clarify its precise mechanisms of action and assess its long-term effects. This review article provides a comprehensive overview of linalool's impact on the brain, highlighting its antioxidant, anti-apoptotic, and anti-inflammatory properties in various neurological disorders.

Development of new medicines with fewer adverse effects and more efficacies is needed for the treatment of psychiatric disorders. The present study aimed to investigate the putative antidepressant and anxiolytic effects of methanolic extract of Salvia spinosa L. (SS) in mice.

Elevated plus-maze (EPM) and open field tests (OFT) were conducted to evaluate anti-anxiety and locomotor activity of animals treated with the methanolic extract of SS [12.5, 25, 50, and 100 mg/kg, intraperitoneal (IP)], respectively. Antidepressant-like activity of the extract was evaluated using forced swim test (FST) and tail suspension test (TST). Total phenol and flavonoid contents were measured using spectrophotometric methods.

IP administration of SS (25, 50, and 100 mg/kg) significantly increased the percentage of time spent and the percentage of arm entries into the open arms of EPM and decreased locomotor activity (100 mg/kg), compared with the control group. Furthermore, the immobility time of animals significantly decreased in both FST and TST with doses of 25, 50, and 100 mg/kg of the extract, as compared to the control group. The total phenolic content of methanolic extract was 55.17 mg of gallic acid equivalents (GAE) per gram of dry extract and total flavonoid content was 53.07 mg of quercetin as equivalents (QE)/ g of extract.

Salvia spinosa L. has antidepressant- and anxiolytic-like effects in animal models of psychiatric disorders.