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عضویت

جستجوی مقالات مرتبط با کلیدواژه "barberry" در نشریات گروه "پزشکی"

  • Shabnam Abbasi*, Zeinab Shohani, Kowsar Pourhashemi

    Blood plays a vital role in the body, carrying oxygen, nutrients, and hormones. Therefore, blood purification is of great importance and guarantees the proper functioning of the body. Medicinal plants have been used by people for the treatment of various diseases in the past. Due to the high side effects of the use of different chemical drugs, in recent years, medicinal plants have been relatively popular. Therefore, in this review, using the keywords of medicinal plants, purification, and blood purification, numerous articles published in this field were searched through Scopus, Google Scholar, Irandoc.ac.ir, and Sid. ir databases. Finally, 87 articles were selected and reviewed. A list of plants effective in blood purification along with their effective ingredients and other therapeutic properties was obtained. According to the results, 45.2% of plants effective in blood purification were native to Iran. Fabaceae, Asteraceae, and Lamiaceae were the most important families, respectively. Plants effective in blood purification can help improve health and purify the blood. Still, the consumption of each plant should be according to the condition of each person's body and consult with a specialist.

    Keywords: Barberry, Blood Purification, Citrus Maxima, Fennel
  • Ghanbar Laei *

    In order to investigate the reproduction of seedless, seeded and ornamental barberry shrubs through tissue culture, a factorial experiment in the form of a completely randomized design in three replications and with three factors, the first factor of three types of barberry shrubs (seedless, seeded and ornamental), the second factor of BAP hormone at four levels (0, 1, 2, 3 mg l-1) and the third factor of IBA hormone at two levels (0 and 0.25 mg l-1) was done in the laboratory of Islamic Azad University, Damghan branch in 2019. The culture medium used was based on Murashige and Stooge (MS). After preparing the culture medium and sterilizing it by autoclave, it was distributed in the test tubes. After preparation, the samples were cultured in a sterile environment and then the samples were stimulated to grow using growth hormones. The investigated traits included germination, number of leaves, length, width and surface of leaves, ratio of width to length of leaves, fresh weight and dry weight of leaves. After collecting information, the data obtained from the experiment was organized and then analysis of variance was performed with SAS statistical software and comparison of means with Duncan's multi-range test. Pearson's correlation coefficient was used in order to determine the relationships of traits. The main effects and some interaction effects on the time of greening, number of leaves, length, width, leaf area and leaf width to length ratio, leaf fresh weight and dry weight were significant. The correlation coefficient shown between the dry weight of leaves with the number of leaves (r=0.88**), leaf length (r=0.74**), leaf width (r=0.74**), leaf area (r=0.75**), green leaf weight(r=0.96**) positive correlation was significant at 1% probability level.

    Keywords: Barberry, Tissue Culture, Cultivation Environment, Ornamental
  • Soodabeh Omidvar Tehrani, Mahboobeh Ghasemzadeh Rahbardar, Kamran Shoorgashti, Mohammad Javad Dehghan Nayeri, Amir Hooshang Mohammadpour *, Hossein Hosseinzadeh
    Objective
    Severe disease onset of COVID-19 may result in alveolar injury and respiratory failure. Apoptosis and inflammation are the main causes of respiratory distress syndrome. Berberine is used in medicine as an analgesic, anti-asthmatic, anti-inflammatory, and antiviral. In the current investigation, the effect of berberine on COVID-19 outpatients was studied.
    Materials and Methods
    The present clinical trial was performed on 40 outpatients who were randomly assigned to berberine (300 mg, TID, 2 weeks) (n=19) or placebo groups (n=21). Both groups received standard therapy and they were monitored on days 3, 7, and 14 after the beginning of the therapy for clinical symptoms’ improvement, quantitative CRP, lymphopenia, CBC, and SpO2. The severity and frequency of these symptoms and the level of the parameters were statistically compared between the two groups.
    Results
    On days (0, 3, 7, and 14, there was no significant difference between the berberine and placebo groups in the improvement of clinical symptoms (cough, shortness of breath, nausea, loss of smell and taste, diarrhea, dizziness, sore throat, stomachache, body aches, and body temperature), quantitative CRP, lymphopenia, WBC, neutrophils, platelets, or SpO2.
    Conclusion
    Berberine (300 mg, TID, two weeks) is ineffective in treating COVID-19. More research with a larger sample size is needed to investigate different berberine dosages in other pharmaceutical formulations.
    Keywords: Clinical trial, Berberis vulgaris, Barberry, Coronavirus disease, Lymphopenia, Antiviral
  • سیده ساره هندی، هانیه حقیقی، شهریار شهریاری*
    مقدمه

    باکتری انتروکوکوس فکالیس (ا.فکالیس) جزو میکروب های فلور نرمال حفره دهان است که یکی از عوامل رایج در عدم موفقیت در درمان کانال ریشه، مربوط به آن می باشد. هدف از این مطالعه، بررسی قابلیت عصاره زرشک در جلوگیری از تشکیل بیوفیلم میکروبی توسط باکتری ا.فکالیس در شرایط آزمایشگاهی بود.

    مواد و روش ها

    در مرحله اول باکتری ا.فکالیس به همراه عصاره پوست و ریشه زرشک کشت داده شد و تشکیل بیوفیلم بعد از 48 ساعت ارزیابی گردید. در مرحله دوم از کشت فعال باکتری در زمان های 48 ساعت، کلیه غلظت های ریشه و پوسته، مهار رشدی مشابه با گروه کنترل داشتند. 2 هفته پس از فعال سازینیز نتایج مانند مرحله اول بود. برای تایید تشکیل بیوفیلم از رنگ آمیزی فلورسانس با SYPRO® Ruby (Invitrogen, USA, 2010) استفاده شد و سپس کلیه نمونه ها توسط میکروسکوپ فلورسانس تحت بررسی قرار گرفتند و نتایج با واحد Relative fluorescence unit (RFU) گزارش گردید.

    یافته ها

    در کشت همزمان زرشک و ا.فکالیس محیط های کشت 30 و 50 درصد ریشه و محیط کشت 30 درصد پوسته مهار رشدی مشابه با گروه کنترل داشتند. پس از اضافه نمودن عصاره پوسته و ریشه زرشک در زمان های 48 ساعت، کلیه غلظت های ریشه و پوسته، مهار رشدی مشابه با گروه کنترل داشتند. در دو هفته پس از کشت ا.فکالیس نتایج مشابه گروه اول بود. در حالی که در نمونه درمان با نرمال سالینو نمونه بدون درمان شبکه ای گسترده و ضخیم از بیوفیلم ها تشکیل شده بود.

    نتیجه گیری

    با توجه به اثرات مثبت عصاره ریشه و پوسته زرشک می توان از آن برای استریل کردن کانال های دندانی استفاده نمود و می تواند جایگزین مناسبی برای هیپوکلریت تلقی گردد.

    کلید واژگان: زرشک, انتروکوک فکالیس, بیوفیلم, درمان ریشه
    Seyedeh Sareh Hendi, Hanieh Haghighi, Shahriar Shahriari *
    Introduction

    Enterococcus faecalis (E. faecalis) is one of the microbes of the normal flora of the oral cavity, which is one of the common factors in the failure of root canal treatment. This in vitro study aimed to evaluate the ability of barberry extract to prevent the formation of microbial biofilm by E. faecalis.

    Materials and Methods

    Initially, E. faecalis was cultured simultaneously with barberry bark and root extract, and biofilm formation was evaluated after 48 h. In the second stage of the active culture of the bacteria (48 h), all root and bark concentrations had similar growth inhibition with the control group. The same results were observed after two weeks. Fluorescence staining with SYPRO® Ruby (Invitrogen, USA, 2010) was used to confirm the formation of biofilm. Subsequently, all samples were examined by fluorescence microscope, and the results were reported using Relative Fluorescence Unit.

    Results

    In the simultaneous cultivation of barberry and E. faecalis, root (30%), growth medium (50%), and bark (30%) had similar growth inhibition with the control group. After adding barberry bark and root extract (48 h), all concentrations of barberry bark and root showed similar growth inhibition with the control group. After two weeks of E. faecalis culture, the results were the same as those of the first group. However, wide and thick biofilms were formed in the samples without treatment and those treated with normal saline.

    Conclusion

    Due to the positive effects of barberry bark and root extract, it can be used to sterilize dental canals and can be considered a suitable alternative to hypochlorite.

    Keywords: Barberry, Biofilm, Enterococcus faecalis, Root Canal Therapy
  • Mohammad Esmaeil Masinaei Nejad, Narges Khanjani *, Maryam Khodadadi, Esmail Najafi
    Background

    Congenital malformations are defects that are present at birth. The purpose of the present study was to determine the status of congenital malformations and their risk factors in Noghab village, South Khorasan Province.

    Methods

    In this case-control study, 152 cases with congenital anomalies and 152 controls were enrolled. A researcher-made checklist and face-to-face interviews were used to record patient data. Chi-square test, Mann-Whitney U, and univariate and multivariate logistic regression in SPSS 22 were used for statistical analysis.

    Results

    One hundred and nineteen (72.5%) patients were male. The overall prevalence of congenital abnormalities in the village was 4.5%. The most prevalent types of disorders were neurological (35.4%) and multiple abnormalities (30.5%). According to multivariate logistic regression, consuming barberries daily during pregnancy, having first-degree relatives with anomalies, daily use of herbal medicine and weekly consumption of pickled vegetables during pregnancy, and the existence of a chronic disease in the father were significantly associated with congenital disorders in the offspring.

    Conclusion

    In addition to the previously known risk factors for congenital malformation, consumption of barberries, herbal medicine and pickled vegetables during pregnancy, might be risk factors for congenital anomalies. These products should be used with caution in pregnant women.

    Keywords: Genetic disorders, Congenital anomalies, Barberry, Prevalence, Iran
  • مقدمه

    رزوراترول و زرشک به عنوان آنتی اکسیدان های طبیعی و تنظیم کننده های متابولیسم انسانی شناخته شده اند. ولی اثرات رزوراترول و زرشک بر مورفولوژی تخمدان در سندروم تخمدان پلی کیستیک ناشناخته است.

    هدف

    این مطالعه قصد دارد که اثر عصاره هیدروالکلی زرشک در ترکیب با زروراترول بر پارامترهای بیوشیمیایی و مورفولوژی تخمدان در رت های بالغ مبتلا به سندروم تخمدان پلی کیستیک به وسیله لتروزول بررسی کند.

    مواد و روش ها

    70 رت ماده از نژاد Sprague-Dawley با سن 12-10 هفته و وزن 20±200 به صورت تصادفی به 7 گروه تقسیم شدند. گروه اول: نرمال، گروه دوم: شم، گروه سوم: رت های مبتلا به سندروم تخمدان پلی کیستیک که به صورت دهانی 1 سی سی نرمال سالین دریافت کردند، گروه چهارم: رت های مبتلا به سندروم که به صورت دهانی 150 میلی گرم بر کیلوگرم وزن، متفورمین دریافت می کردند، گروه پنجم: رت های مبتلا به سندروم که به صورت دهانی 20  میلی گرم بر کیلوگرم وزن، رزوراترول دریافت می کردند، گروه ششم: رت های مبتلا به سندروم که به صورت دهانی 3 گرم بر کیلوگرم وزن، زرشک دریافت  می کردند، گروه هفتم: رت های مبتلا به سندروم که به صورت دهانی 3 گرم بر کیلوگرم وزن، زرشک و 20 میلی گرم بر کیلوگرم وزن، رزوراترول دریافت می کردند.

    نتایج

    رزوراترول به تنهایی یا با ترکیب با زرشک در رت ها منجر به کاهش معناداری در LDL ,TG ,MDA و TNFα شد در حالی که درمان با زرشک، رزوراترول، ترکیب زرشک و رزوراترول و متفورمین منجر به افزایش معناداری در SOD ,TAC و HDL شد.

    نتیجه گیری

    رزوراترول، زرشک و ترکیب آنها به عنوان ترکیبات طبیعی با عوارض جانبی کمتر ممکن است بتوانند به عنوان درمان جایگزین در سندروم تخمدان پلی کیستیک استفاده شود.

    کلید واژگان: زرشک, رزوراترول, سندروم تخمدان پلی کیستیک, تخمدان, رت
    Fatemeh Ashkar, MohammadHassan Eftekhari, Nader Tanideh*, Farhad Koohpeyma, Maral Mokhtari, Kambyz Irajie, Aida Iraji
    Background

    Resveratrol and Berberis integerrima (B. integerrima) are known to be natural antioxidants and regulators of human metabolism. However, the effects of resveratrol and B. integerrima on the ovarian morphology in polycystic ovary syndrome (PCOS) are not obvious.

    Objective

    This study aimed to determine the effect of the hydroalcoholic extract of B. integerrima in combination with resveratrol on some biochemical parameters and ovarian morphology in the letrozole-induced PCOS rat.

    Materials and Methods

    Seventy adult female Sprague-Dawley rats aged 10-12 weeks  weighing 200 ± 20 gr were randomly divided into seven groups (n = 10/each). Group I): normal; Group II): vehicle; Group III): letrozole-induced PCOS 1 mg/kg letrozole orally, rats receiving 1 cc normal saline orally; Group IV): PCOS + receiving 150 mg/kg metformin orally; Group V): PCOS + receiving 20 mg/kg resveratrol orally; Group VI): PCOS + 3 gr/kg barberry orally; and Group VII): PCOS + receiving 3 gr/kg barberry and 20 mg/kg resveratrol orally. All animals were followed-up for 63 days. The biochemical parameters and histological assessments of ovaries were performed.

    Results

    Resveratrol alone and/or in combination with B. integerrima treatment in rats led to a significant decrease in low-density lipoprotein, triglyceride, malondialdehyde , and tumor necrosis factor-alpha concentrations (p = 0.02). The groups IV, V, VI, and VII showed a decrease in insulin resistance and an increase in the superoxide dismutase, total antioxidant capacity, and high-density lipoprotein (p =0.01). No significant difference was observed between the level of serum glucose in the treatment groups. Number of cystic follicles had a significant decrease in barberry, resveratrol, and their combination groups (p < 0.001).

    Conclusion

    Resveratrol, B. integerrima, and their combination as natural products with fewer side effects might be effective as an alternative medicine in treatment of PCOS.

    Keywords: Barberry, Resveratrol, Polycystic ovary syndrome, Ovary, Rat
  • سمیه رضایی، فرنگیس قاسمی*
    زمینه و هدف

    با توجه به اثرات نامطلوب مصرف بعضی مواد غذایی در دوران بارداری، در این تحقیق، اثر مصرف عصاره آبی میوه زرشک (Berberis vulgaris ) بر تکوین کبد و کلیه بررسی گردید.

    مواد و روش ها:

     56 سر موش صحرایی ماده (20±188 گرم(و 8 موش نر)20±188 گرم(انتخاب و لقاح داده شد. موش های باردار در گروه های کنترل (بدون تیمار)، شاهد (دریافت کننده سرم فیزیولوژی) و 2 گروه تیمار (دریافت کننده 2/0 سی سی از عصاره آبی زرشک با دوز mg/kg/bw 20 و 50 به صورت تزریق درون صفاقی) تقسیم و تیمار روزانه از روز 6 تا 10 بارداری انجام شد. موش ها در روز 14 و 20 بارداری تشریح شدند. کلیه و کبد جنین ها جدا و پس از تثبیت در فرمالین 10% و پاساژ بافتی، از آن ها مقاطع 5 میکرونی تهیه و اسلایدهای حاصل، رنگ آمیزی گردید. جنین ها مرفومتری شده و تغییرات بافتی در میکروگراف ها مطالعه شد. داده ها با ANOVA و آزمون کای اسکور تحلیل شدند.

    نتایج

    اندازه قد در جنین تیمارهای 20 روزه کاهش و وزن افزایش معنی دار (01/0>p) نشان دادند. بافت کبد جنین تیمارهای 20 روزه، پرخونی سنوزوییدها، تخریب اندوتلیوم عروق و کاهش تعداد و واکوئله شدن هپاتوسیت ها را نشان دادند. تغییرات جزئی در بافت کلیه جنین تیمارهای 20 روزه مثل تخریب اپیتلیوم مجاری مشاهده گردید.

    نتیجه گیری:

     بنا به نتایج حاصل، زرشک به صورت وابسته به دوز و سن جنین، بر بافت کبد جنین و تا حدودی بر کلیه آثار منفی دارد. لذا مصرف کمتر آن در دوران بارداری توصیه می شود.

    کلید واژگان: جنین, زرشک, هپاتوسیت, مجاری ادراری
    Somaye Rezaii, Farangis Ghassemi*
    Background & Objective

    Considering the undesirable effects of eating some foods during pregnancy, this study investigated the effect of aqueous fruit extract of Berberis vulgarison on the development of liver and kidney.

    Materials & Methods

    56 female rats (188 ± 20 gram) and 8 male rats (188 ± 20 gram) were selected and fertilized. The pregnant rats were divided into the control group (without treatment), sham (received physiological serum) and 2 treatment groups and received 0.2cc of aqueous extract of Berberis vulgaris at doses of 20 and 50 mg/kg/bw ) by intraperitoneal injection daily from the 6th - 10th day of gestation. Half of the rats were dissected on 14thand 20thof pregnancy. The kidneys and livers of embryos were removed and fixed in 10% formalin. The sections (5 micron) and slides were prepared and stained. The morphometric study was conducted, and tissue changes in the micrographs were studied. The data were analyzed by ANOVA and Chi-squared test.

    Results

    The significant decrease in height (P<0.01), and significant increase in weight of treatment fetus (20-day-old) were observed. The liver tissue of treatment 20-day-old fetus showed sinusoid hyperemia, vascular endothelium degeneration, reduction in the number of hepatocytes and their vacuolation. The moderate changes were observed in kidney tissue as degradation of the duct epithelium, in the 20-day-old embryos.

    Conclusion

    According to obtained finding, Barberry has negative effects in a dose- and time-dependent manner on the liver, and somewhat on kidney of fetus. Therefore, its utilization should be limited during pregnancy.

    Keywords: Embryo, barberry, hepatocyte, urinary tract
  • Davood Mehrabani, Mahbobe Zabeti, Akbar Vahdati, Mehdi Pasalar *, Mina Rabiee, Seyed Jalil Massoumi
    Background
    Nowadays, the use of herbal medicine for the treatment of different diseases especially during pregnancy is increasing. It was shown that some herbs have irreparable effects on fetal development and on pregnancy. The aim of this study was to investigate the effect of aqueous extract of Berberis vulgaris on fetal height and weight during pregnancy.
    Methods
    One-hundred and twenty adult female mice were enrolled. After confirmation of pregnancy, they were divided to four groups evaluated during first, second and third week of pregnancy. The control group mice were pregnant without any intervention. The second, third and fourth group received 2000, 3500 and 5000 mg/kg of barberry, respectively. The fetal weight and height were measured in each group and compared.
    Results
    In the first, second and third week of gestation, 5000 mg/kg of barberry decreased the embryo’s weight and height in comparison to other groups.
    Conclusion
    The high dose of barberry resulted in adverse effects on fetal growth especially in the last week of pregnancy. Therefore, it should be administered with caution during gestation period.
    Keywords: Barberry, Fetus, Height, Weight, Pregnancy
  • بابک هوشمند مقدم*، مژگان اسکندری، ناهید بیژه، محسن محمدنیا احمدی، جواد نوروزی
    زمینه و هدف
     با توجه به تغییرات فیزیولوژیکی و ایمونولوژیکی بدن انسان به دنبال فعالیت حاد وامانده ساز و شواهد موجود در طب سنتی از آثار زرشک در تقویت سیستم ایمنی، هدف از مطالعه حاضر ارزیابی اثر مکمل یاری کوتاه مدت آب زرشک بر پاسخ ایمونوگلوبین هایA،G ،M  و کورتیزول دختران فعال متعاقب فعالیت ورزشی وامانده ساز بود.
    روش کار
    در این مطالعه کار آزمایی بالینی،20 دختر جوان فعال سالم (سن 28/1±92/23 سال؛ وزن 71/5±69/55 کیلوگرم) به طور تصادفی در دو گروه تجربی (مصرف 250 میلی لیتر آب زرشک و فعالیت درمانده ساز) و کنترل (مصرف 250 میلی لیتر دارونما و فعالیت درمانده ساز) قرار گرفتند. هر دو گروه پس از مکمل یاری دو هفته ای، فعالیت ورزشی منتخب تا حد واماندگی را بر روی نوارگردان اجرا کردند. در این پژوهش ارزش غذایی آب زرشک استخراج و تغذیه آزمودنی ها مورد تحلیل قرار گرفت. نمونه های خونی جهت سنجش متغیرهای ایمنی هومورال در شرایط مشابه در سه مرحله پیش آزمون، پس از دو هفته مکمل یاری و پس از آزمون وامانده ساز، اندازه گیری و با استفاده از آزمون های تی مستقل، آنالیز واریانس با اندازه گیری مکرر و آزمون تعقیبی بونفرونی در سطح 05/0p≤ تجزیه وتحلیل شدند.
    یافته ها
    نتایج نشان داد که در گروه مصرف کننده آب زرشک مقادیر ایمونوگلوبین های A (026/0=p)، G (013/0=p) وM  (017/0=p) پس از فعالیت حاد وامانده ساز به طور معناداری نسبت به گروه کنترل، بیشتر بود؛ درحالی که در گروه تجربی مقادیر کورتیزول (018/0=p) به طور معناداری کمتر از گروه کنترل بود.
    نتیجه گیری
    به نظر می رسد، مصرف دو هفته آب زرشک با افزایش کارایی سیستم ایمنی بدن باعث کاهش آثار سرکوبگر فعالیت حاد وامانده ساز  بر سیستم ایمنی دختران فعال می شود
    کلید واژگان: زرشک, فعالیت وامانده ساز, ایمونوگلوبین, کورتیزول
    Babak Hooshmand Moghadam*, Mozhgan Eskandari, Nahid Bijeh, Mohsen Mohammadnia Ahmadi, Javad Norouzi
    Background and Purpose
     Regarding the physiological and immunological changes of the human body following the acute exhaustive activity and the evidence in traditional medicine of the effects of barberry on the strengthening of the immune system, and since saffron is a valuable and rich carotenoids spice and has been used in traditional medicine for a variety of uses, the aim of this study was Evaluation of the Effect short-term Barberry Juice Supplementation On the response of immunoglobulin A, G, M and cortisol in active girls following exhaustive exercise activity.
    Methods
    In this clinical trial study, 20 healthy young girls (23.92 ± 1.28 years, weight 55.69 ± 5.71 kg) were randomly divided into two experimental group (Consumption of 250 ml Barberry Juice and exhausting activity) and control group (Consumption of 250 ml placebo and exhausting activity). After the two-week supplementation, both groups performed exercise activity until they were of exhaustion on the treadmill. In this research, the nutritional value of Barberry Juice was extracted and the subjects' nutrition was analyzed. Blood samples were measured to measure the humoral immune variables in similar conditions in three stages of pre-test, after two weeks of supplementation and after the exhaustive test and using Independent T-test, ANOVA with repeated measure and Bonferron's post hoc test were analyzed at p≤0.05.
    Results
    The results showed that in the experimental group, the levels of immunoglobulin A (p=0.026), G (p=0.013) and M (p=0.017) after acute exhaustive activity were significantly higher than the control group, whereas in the experimental group cortisol values (p = 0.018) were significantly lower than the control group.
    Conclusion
    It seems that, Consumption of Barberry Juice for two weeks with increased immune function, Reduces the effects of acute exhausting activity on the immune system in active girls.
    Keywords: Barberry, exhausting activities, Immunoglobulins, Cortisol
  • Nooshin Mohammadzadeh, Soghra Mehri, Hossein Hosseinzadeh*
    Berberis vulgaris L (B. vulgaris) and its main constituent berberine have been used in traditional medicine for a long time. This medicinal plant and berberine have many properties that have attracted the attention of researchers over the time. According to several studies, B. vulgaris and berberine exhibited anti-inflammatory, antioxidant, anticonvulsant, antidepressant, anti-Alzheimer, anti-cancer, anti-arrhythmic, antiviral, antibacterial and anti-diabetic effects in both in vitro and in vivo experiments. In regard to many reports on protective effects of B. vulgaris and berberine on natural and chemical toxins, in the current review article, the inhibitory effects of these compounds against natural, industrial, environmental and chemical toxicities with focus on cellular mechanism have been categorized. It has been mentioned that berberine could ameliorate toxicity of chemical toxins in brain, heart, kidney, liver and lung in part through antioxidant, anti-inflammatory, anti-apoptotic, modulation of mitogen-activated protein kinase (MAPK) and nuclear factor-ĸB (NF-ĸB) signaling pathways.
    Keywords: Antidote, Anti-inflammation, Antioxidant, Barberry, Berberine, Berberis vulgaris, Chemical toxin, Natural toxin
  • Berberine attenuates convulsing behavior and extracellular glutamate and aspartate changes in 4-aminopyridine treated rats
    Hamid Reza Sadeghnia, Ali Reza Taji, Fatemeh Forouzanfar, Hossein Hosseinzadeh *
    Objective(s)
    K channel blocker 4-aminopyridine (4-AP) stimulates the release of glutamate from nerve terminals and induces seizures. Berberine as a potential herbal drug exerts several pharmacological actions on the central nervous system including anxiolytic, anticonvulsant, and neuroprotective properties. The present study aimed to investigate the effect of berberine on seizure onset and time course of the extracellular levels of excitatory amino acids (EAA), glutamate and aspartate, changes produced by 4-AP in rat hippocampus.
    Materials And Methods
    The rats were given either saline or berberine (50, 100 and 200 mg/kg, IP) 40 min before administration of 4-AP (15 mg/kg, IP) and the onset of seizure was recorded. A group of rats also received diazepam (DZP, 15 mg/kg, IP) 20 min prior to 4-AP administration. Hippocampal extracellular levels of EAA were also measured using microdialysis assay. Analysis of the dialysate samples was performed by reversed-phase high performance liquid chromatography (HPLC) with precolumn derivatization with o-phthaldialdehyde and fluorescence detection.
    Results
    Our findings suggest that berberine significantly delayed the seizure onset following 4-AP injection. There was a considerable increase in the extracellular glutamate and aspartate levels in 4-AP treated rats and 4-AP-evoked release of EAA was sharply reduced (about 4-5 fold especially at 20 min after 4-AP administration) in berberine treatment groups.
    Conclusion
    The results of present study show that berberine attenuates 4-AP induced seizures by decreasing hippocampal aspartate and glutamate release in rats.
    Keywords: Barberry, Berberis vulgaris, Berberine, Excitatory amino acids, 4-Aminopyridine (4-AP), Seizure
  • Zahra Abootorabi, Maliheh Poorgholami, Mohammad Yahya Hanafi-Bojd, Reyhane Hoshyar *
    Recently, synthesis of gold nanoparticles (AuNPs) is the subject of a lot of studies due to various applications in medicine, agriculture, and industry. The development of non-toxic and safe methods such as green chemistry to produce AuNPs is obviously recommended. In the current study, 2 antioxidant rich herbs of barberry and saffron stigma were applied as reducing agents for the 1-pot synthesis of size-controlled AuNPs. These AuNPs were characterized through ultraviolet-visible spectrophotometry (UV-vis), transmission electron microscopy (TEM), and X-ray diffraction (XRD) techniques. Optimal temperature and pH for the biosynthesis of AuNPs conjugated with herbs were 50°C and 7.5, respectively. XRD and TEM results authorized AuNPs production in 5 - 15 nm for barberry and 5 - 10 nm for saffron and confirmed the stability, sphericity, and uniformity for both the nanoparticles.
    Keywords: AuNPs, Barberry, Saffron, Antioxidan
  • Maryam Valavi, Fateme Mezginejad, Fatemeh Haghighi, Mina Hemmati *, Asghar Zarban, Elham Rabiei Gask
    Background
    The use of herbal medicine has recently increased because of its effectiveness, limited side effects, and easy accessibility. In the present study, we investigated the antioxidant properties and diabetes treatment potential of 3 medicinal plants of barberry, saffron, and jujube.
    Methods
    In the present study, 65 diabetic male Wistar rats were randomly divided into 13 groups. Groups 1 to 6 included diabetic rats that received hydroalcoholic extracts and groups 7 to 12 received aqueous extracts of the plants. The rates in Group 13 were diabetic controls, and 5 male Wistar rats were used as non-diabetic controls. Total antioxidant capacity, lipid peroxidation, radical scavenging activity, and fasting blood glucose were measured at the end of the 21st day of the treatment.
    Results
    Hydroalcoholic and aqueous extracts of the plants decreased malondialdehyde, and in contrast, increased total antioxidant levels (P ≤ 0.05). Increased levels of insulin and decreased levels of FBG in all treated groups were observed, which were notable for hydroalcoholic extract of saffron.
    Conclusions
    The antioxidant properties of the plants, especially saffron and jujube, lead to the regeneration of pancreatic islet and probably increase insulin release in these treatment groups; and, the plants exert their beneficial antidiabetic effects because of their antioxidant potential.
    Keywords: Diabetes, Oxidative Stress, Jujube, Saffron, Barberry
  • Mansoureh Pashaee, Abdolhossein Shiravi, Vida Hojati
    Diabetes mellitus is one of the most common diseases of the endocrine system. Barberry (Berberis vulgaris), as a common herb incorporated in treatment of various diseases, is used as anti-itch and anti-microbial medicine as well as lowering blood sugar and blood pressure. In this study, the effects of a hydroalcoholic extract of B. vulgaris on skin wound healing of diabetic rats were investigated. Forty eight male Wistar rats weighting 180 to 230 g were divided into four groups: control group (non-treated non-diabetic rats), sham group (oserin-treated diabetic rats), experimental 1 group (non-treated diabetic rats), experimental 2 group (B. vulgaris extract-treated diabetic rats) and then, 3-cm-length cuts were created on the skin of the dorsal lumbar region and then the wounds were treated on a daily basis. Lesion length measurements were conducted during the experiments using a caliper. For the purpose of histological studies, wound samples were taken from each group and finally, statistical data analysis was conducted using the one-way ANOVA test in addition to the Duncan test performed using the SPSS software. The results indicated that the second experimental group had the best influence on wound healing compared to others. Accordingly, the B. vulgaris extract might be able to improve the wound healing process along with reducing the lesion length due to its anti-diabetic and antimicrobial effects in rats after 21 days.
    Keywords: Diabetes, Barberry, Skin lesions, Rats
  • حلیمه صادقی، مریم اخوتی
    سابقه و هدف
    بررسی برون داد علمی یکی از مهم ترین شاخص های پژوهش و تولید علم شناخته می شود. با توجه به اهمیت گیاه زرشک در طب سنتی و جدید، این پژوهش به منظور بررسی تحقیقات انجام شده روی گیاه دارویی زرشک در پایگاه های اطلاعاتی معتبر تا سال2013 انجام گرفت.
    مواد و روش ها
    پژوهش توصیفی تحلیلی است که در آن مدارک نمایه شده در دو پایگاه اطلاعاتی Web of Science و Scopus توسط نرم افزارهای تحلیل گر دو سایت تجزیه و تحلیل شد. همچنین برای تعیین ارتباط بین مشارکت علمی و تعداد استناد، ضریب همبستگی پیرسون، محاسبه شد.
    یافته ها
    803 رکورد از پایگاه Web of Science و 1278 رکورد از Scopus بازیابی شد. پرکارترین نویسنده در دو پایگاه Karimov، A بود. مجله « Khimiya prirodnykh soedinenii» با 26 مقاله در Web of Science و Khimiya prirodnykh soedinenii« با 44 مقاله مهم ترین مجله شناخته شد. »دانشگاه علوم چین« در Web of Science (28 مقاله) و دانشگاه کانکتیکات آمریکا (24 مقاله) در Scopus از نظر تولید علم در رتبه اول قرار دارند. بیشترین تولیدات علمی در دو پایگاه متعلق به کشور آمریکا و موضوع غالب در حوزه علوم پزشکی، در Web of Scienceداروسازی و در اسکوپوس پزشکی داخلی بوده است. رابطه معناداری بین تعداد نویسندگان و تعداد استناد دریافتی مدارک تولید شده در زمینه زرشک وجود نداشت.
    نتیجه گیری
    در این تحقیق مجلات مهم، نویسندگان پرکار، موسسه های فعال و کشورهای پیشرو در زمینه زرشک مشخص شدند که الگوی مناسبی برای پژوهشگران این حوزه در داخل کشور و خارج کشور جهت ارتقای سطح کیفی و کمی تحقیقات است
    کلید واژگان: تولیدات علمی, زرشک, اسکوپوس, وب آو ساینس
    H. Sadeghi, M. Okhovati
    Background and
    Purpose
    Investigation of scientific output is known as one of the most important indicators of research and knowledge production. With respect to the importance of berberis in traditional and modern medicine, this study aims to investigate the research conducted on berberis medicinal plant in authoritative databases and the contribution of the medical field during 1993 to 2013.
    Materials And Method
    This is a descriptive-analytical research in which indexed documents in Web of Science and Scopus were analyzed by analyst softwares of the two databases. Pearson coefficient was calculated to determine the relationship between scientific contribution and citation rate.
    Results
    803 and 1278 documents were retrieved from Web of Science and Scopus, respectively. In both databases, “Karimov, A” had the most papers. “Khimiya Prirodnykh Soedinenii” included 26 documents in Web of Science and 44 ones in Scopus, therefore, they were published the most papers on berberis. “China Sciences” university published the most papers in Web of Science and “University of Connecticut America”had the most papers in Scopus. The highest rate of papers published belonged to U.S and the dominant subject in Scopus was pharmacology and in Web of Science the dominant subject was internal medicine. No significant relationship was observed between the number of authors and the citation rate.
    Conclusion
    The prolific authors, influential journals, active institutions, and leading countries were identified. The findings present a suitable pattern for researchers and policy makers in Iran and abroad to improve the quantity and quality of research in this field.
    Keywords: Scientific Products, Barberry, Scopus, Web of Science
  • Ali Zarei, Saeed Changizi Ashtiyani, Soheila Taheri, Majid Ramezani
    Many herbaceous plants contain compounds that have biological effects in addition to their medicinal properties. They have compounds with numerous properties, including hypo lipidemic, hypoglycemic, antioxidant, and hepato protective ones, which have been analyzed at different levels. One of these plants, with the scientific name of Berberis vulgaris, is barberry. The most important compounds identified in this plant are berberine, oxycontin, palmatine, bervulcine, berbamine, columbamine, jatrorrhizine, coptisine, and berbamine. In addition to alkaloids, organic acids such as chelidonic acid, citric acid, malic acid, resin, tannin, pectinic, and mucilagic substances are among the ingredients of barberry. In this paper, it was attempted to determine the role and effect of the extract of barberry on various body organs. The results showed that berberine actually increases insulin sensitivity and is capable of inhibiting alpha glucosidase, adipogenesis, and thus acts as an anti-obesity and hypoglycemic agent. Berberine reduces the density of serum cholesterol and triglycerides and can improve the function of liver enzymes, therefore, it can be suggested as a hypo lipidemic and hepato protective plant extract. The hepato protective effects of this extract are probably due to its antioxidant properties. Studies showed that barberry have numerous health benefits, including anti-inflammatory ones. Moreover, it can be used as a medicinal herb to treat a variety of disorders, such as diabetes, liver disease, gallbladder pain, digestive, urinary tract diseases, and gallstones. However, more studies on this issue and doing more focused and intensive researches in this field are recommended.
    Keywords: Liver, Cholesterol, Diabetes, Thyroid, Barberry, Berberis vulgaris
  • Dr Mr Rezaei, Dr Mh Sayadi *, M. Khaksarnejad
    Background
    Soil pollution and accumulation of heavy metals in crops in industrial areas is one of the most important environmental issues threatening the life of plants, animals, and humans. The aim of this study was to determine the concentration of Cr and Cd in the soil and barberry plants in farms surrounding the Qayen Cement Company, South Khorasan Province, Iran.
    Materials And Methods
    In this study, 8 soil samples were collected from a depth of 0-30 cm and 30-60 cm and 4 samples of barberry plant containing fruits and leaves in summer 2014. The concentrations of Cr and Cd in the samples were determined using atomic absorption spectrometry.
    Results
    The maximum concentration of Cr and Cd was observed in the soil sample collected from a depth of 0-30 cm (95.10 and 1.32 mg/kg of soil, respectively). The concentration of Cr and Cd was higher in the fruits of barberry than the leaves; 18.58 mg/kg and 59.45 µg/kg, respectively, which are higher than the standard values. Transfer factor was calculated as less than 1 for all stations.
    Conclusions
    According to obtained results, Qayen Cement Company has the greatest impact on plants in this region. The barberry fruit is the strategic product in Qayen; therefore, attention to and management of the impact of the cement factory on agricultural products is necessary.
    Keywords: Heavy metals, Transfer factor, Cement plant, Barberry
نکته
  • نتایج بر اساس تاریخ انتشار مرتب شده‌اند.
  • کلیدواژه مورد نظر شما تنها در فیلد کلیدواژگان مقالات جستجو شده‌است. به منظور حذف نتایج غیر مرتبط، جستجو تنها در مقالات مجلاتی انجام شده که با مجله ماخذ هم موضوع هستند.
  • در صورتی که می‌خواهید جستجو را در همه موضوعات و با شرایط دیگر تکرار کنید به صفحه جستجوی پیشرفته مجلات مراجعه کنید.
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