جستجوی مقالات مرتبط با کلیدواژه « beta-defensins » در نشریات گروه « پزشکی »
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Background
This study compared human β-defensin 1 (hBD-1) salivary levels in patients with periodontitis before and after phase I periodontal therapy.
MethodsThis controlled before-and-after study included 16 patients in the intervention group and 28 participants in the control group. Patients in the intervention group had stage 3 grade B periodontitis with no systemic diseases and had not taken any medications in the last six months. The control group included participants with healthy periodontium. Before and after phase I periodontal therapy, salivary samples were collected from the intervention group. ELISA was used to measure hBD-1 levels.
ResultsSalivary levels of hBD-1 decreased after phase I periodontal treatment in periodontitis patients, approaching those in healthy individuals. However, this reduction was not statistically significant (P=0.389). In patients with a probing depth (PD) of at least 3 mm, salivary levels of hBD-1 decreased significantly (P=0.019) following the intervention. There was no significant correlation between changes in hBD-1 levels and clinical indices, such as clinical attachment loss (CAL), probing depth, or bleeding index (BI) (P˃0.05).
ConclusionThe current study demonstrated promising results concerning a probable link between hBD-1 and periodontitis. However, more research with sufficiently large sample sizes and more robust study designs is necessary.
Keywords: Beta-Defensins, Chronic Periodontitis, Enzyme-Linked Immunosorbent Assay, Root Planing} -
BackgroundYogic stretching (asana) has been proven to have an effect on salivary human beta‑defensin‑2 (HBD‑2) concentration, which is an antimicrobial peptide and is an inflammatory marker in periodontal disease. Sudarshan Kriya Pranayama (SKP) is a part of yoga which involves rhythmic breathing. Hence, we aim to evaluate the periodontal parameters and to estimate the salivary HBD‑2 level before and after SKP program in periodontitis individuals.Materials and MethodsAn interventional study was designed and individuals were divided into three groups: Group I – healthy periodontium, Group II – chronic gingivitis, and Group III – chronic periodontitis. SKP was the interventional tool. The clinical parameters such as plaque index (PI), gingival index (GI), probing pocket depth (PPD), clinical attachment level (CAL), and salivary HBD‑2 level were analyzed at baseline and 90 days after the SKP practice. Enzyme‑linked immunosorbent assay (ELISA) was used to evaluate salivary HBD‑2. McNemar’s Chi‑square, Paired samples t‑test, and one‑way ANOVA were used to analyze the results. P < 0.05 was considered statistically significant.ResultsFollowing the SKP intervention, the clinical parameters such as PI and GI improved significantly in all the groups (P < 0.001); however, Group III showed a significant reduction as compared to the other groups. The mean baseline salivary HBD‑2 levels of Group I, Group II, and Group III were 91.78 ng/μl, 110.22 ng/μl, and 157.63 ng/μl which was further decreased to 95.22 ng/μl, 98.22 ng/μl, and 132.88 ng/μl, respectively, following SKP intervention (P < 0.001). However, Group III had a higher HBD‑2 level at 90th day as compared to other groups.ConclusionThere was an improvement in PI and GI with a decrease in salivary HBD‑2 in chronic periodontitis patients following SKP. Hence, SKP can be considered as an adjunct to treatment modality in patients with periodontal disease.Keywords: beta-defensins, Human, periodontal disease, yoga}
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