جستجوی مقالات مرتبط با کلیدواژه "bnp" در نشریات گروه "پزشکی"

Recently, various serum markers have been used for the diagnosis and prognosis of acute heart diseases in emergency departments. Thus, the present study was designed and conducted to determine such a role. This is an Analytical Cross-Sectional study conducted on the patients with syncope complaints. The patients were entered the study based on the inclusion and exclusion criteria and were subjected to initial evaluations including history, physical examination, ECG, blood sugar measurement, and, if necessary, brain CT scan, Doppler echocardiography, and CTA. A hundred people complaining of syncope were included in this study. The results showed that 19% and 81% of the subjects were suffering from cardiac and non-cardiac syncope, respectively. The average Pro BNP of the studied individuals was 196.06 ± 128.45 pg/ml. according to the results, age and length of hospitalization had a positive and significant relationship with the average Pro BNP (P value<0.01). Furthermore, the average Pro BNP was significantly higher in the people with positive TPI, cardiac syncope, and abnormalities in ECG and Doppler findings (P value<0.01). The results of the diagnostic value of Pro BNP in identifying cardiac syncope also showed that its sensitivity and specificity were 94.73% and 56.79%, respectively. The results of this study showed that the increase in the Pro BNP values was associated with age, increased length of hospitalization, and ECG abnormalities. In addition, as an independent marker, Pro BNP had good acceptability in identifying cardiac syncope cases.

Thyroid hormones (THs) have different effects on the heart and peripheral vascular system. Several changes occur across different status of thyroid dysfunctions. Overt hyperthyroidism (OHyper) induces significant changes in cardiac functions. Untreated OHyper is a cause of heart failure (HF). B-type Natriuretic Peptide (BNP) synthesized primarily in the myocardium. Thus, it is recommended as a diagnostic and prognostic marker for patients with HF. The present study was conducted to measure the effects of OHyper on the BNP level. A case-control study was conducted at a private clinic; Mosul Daily Surgical Clinic, Mosul, Nineveh, Iraq. From 1st Oct., 2020 to 1st Mar., 2021. Thirty (30) apparently healthy subjects with normal thyroid functions; Euthyroid (EU) subjects regarded as control group. Another newly diagnosed thirty (30) OHyper patients were enrolled in this study after exclusion of any facts that affect BNP level as cardiac disease, hypertension, patient taking angiotensin converting enzyme inhibitor, and pregnant ladies. They were diagnosed on the basis of thyroid function tests (TFTs); Thyroid Stimulating Hormone (TSH), Free Triiodothyronine (FT3) and Free Thyroxine (FT4). Plasma level of BNP were measured in OHyper and EU subjects’ group. Plasma BNP level is higher in patients with OHyper than EU individuals with mean values of 27.40± 35.59 and 21.68± 28.57 pg ml-1, (p>0.05) respectively. Moreover, there was a positive correlation between plasma BNP and serum FT4 level in EU (r=0.31, p=0.01) and in OHyper patients (r=0.57, P=0.001). OHyper affect plasma BNP level possibly influencing the secretion of this peptide. Therefore, thyroid functions have to be considered when evaluating any high plasma BNP level.

Congestive heart failure is heart muscle failure that causes pulmonary congestion and eventually pulmonary edema, which despite recent medical advances, is still a progressive syndrome with high mortality, the prevalence of which has increased in recent decades. Therefore, in this study we compared lung ultrasound findings in acute heart failure patients with the BNP.

This study was performed in the emergency room of Imam Reza hospital in Tabriz. For patients entering the emergency room after taking a history, both standard gold (BNP) tests and beside ultrasound of the lung were performed. Ultrasound was performed at the same time as obtaining blood sample to ensure that the ultrasound specialist did not know the result of diagnosis. During the ultrasound, if there were multiple B-Lines that were at least 3 mm apart, patient was diagnosed with pulmonary edema due to heart failure.

Number of participants in this study was 108 people, 54.6% of whom were men and the rest were women. The correlation coefficient between width and number of kerley lines was 0.79, between NT-pro BNP and width of kerley lines was 0.65 and between NT-pro BNP and number of kerley lines was 0.77, which indicates a significant positive correlation (P value <0.001).

The results of present study showed that in patients with acute heart failure, the number and width of kerley lines in pulmonary ultrasound evaluation increase rapidly. There is also a high correlation between number and length of kerley lines with NT-pro BNP serum values.

BackgroundCongenital heart disease (CHD) is the most common cause of major congenital birth defect. The aim of this study was to investigate the association of CHD with serum levels of Tumor necrosis factor-α (TNFα), Interleukin 6 (IL-6), and B-type Natriuretic Peptide (BNP) in infant and children.
Materials and MethodsThe present study was conducted in Heshmat heart hospital and 17 Shahrivar hospital Rasht city, Iran. In 50 children, 25 with CHD and 25 age and sex-matched healthy children (were selected from companions or patients without heart disease), 3 ml vein blood samples of right hand were taken by a trained nurse and samples were sent to a private laboratory. After separation, the plasma placed at temperature of -20 °c. ELISA kits used for measuring BNP and eBioscience Bender MedSystems GmbH kit for measuring IL-6 and TNF-α. The results were entered into SPSS software (version 20.0).
ResultsSerum levels of TNF-α and IL-6 and BNP in the healthy and patient groups were evaluated and by comparing results of the two groups there was no significant difference in serum levels of TNF-α and IL-6, but the serum levels of BNP has significant difference between two groups (80.7 ± 52.5 pg/ml vs. 455.4 ± 550.4 pg/ml, P=0.003). There was no significant relationship between BNP changes with changes in serum TNF-α, IL-6 levels.
ConclusionOur study provided conclusive evidence BNP level is elevated in children with CHD; and significant relationship was observed between incidents of CHD respect to changes in serum BNP level.

Myocardial infarction (MI) is the irreversible cell death caused by ischemia in parts of myocardium. Atrial and brain natriuretic peptides (ANP and BNP) are known as strong markers of myocardial infarction. This research aimed to evaluate the effect of precedent of six-week light intensity interval training (LIIT) on the ANP and BNP gene expression in rats after Myocardial Infarction. Twelve Wistar male rats of 10 weeks old and mean weight 250-300gr were allocated in two groups with six Rats in each groups of 1. LIIT (60 minutes interval running on a treadmill, each cycle including four minutes of running with an intensity of 55-60% VO2max and two minutes of active recovery with a 45-50% VO2max intensity, three days a week for six weeks) and 2. control group (without any precedent of training). Real-time PCR was used to assess the expression of ANP and BNP genes in myocardium (after inducing MI By blocking left coronary artery by surgery). For statistical analysis of data independent sample t test (p≤0.05) was used. Light intensity interval training has significant effect on decreasing the gene expression of ANP (p=0.01) and BNP (p=0.001) in rats after myocardial infarction. It appears that adaptation to light intensity interval training controls and moderates the secretion of cardiac hormones in rats after myocardial infarction.

This study aimed to assess Brain Natriuretic Peptide in early diagnose of cardiac function in children with Congenital Heart Diseases.
This study was performed on children with CHD and healthy. Severity of heart failure modified Ross classification system was used for grouping patients in four classes. For all participants, height, weight and head circumference were measured. From participants 3 cc blood samples was taken and after separation, the plasma placed at temperature of -80 c. After collecting all samples they were in testing using an ELISA BNP kit. For 50 children in control group statistical methods used to generate RV and PA pressure randomly. The data were analyzed using SPSS for Windows, Version, 15.0 (Chicago,SPSS Inc. USA) with 0.05 for the level of significant.
BNP, RV pressure, PA pressure, HB and O2 saturation had different means in cyanotic, Acyanotic and and control significantly. BNP, RV, PA , HB and O2Sat had different means in case and control significantly. , RV, HB and O2 saturation had different means significantly acordance with the sevirity of disease.BNP had correlation with PA and PA had correlation with Qp/Qs ratio ,Rp/Rs ratio , RV and O2Sat significantly .
At the end from the results of the study concluded that BNP levels in children with chd increased.
in patients with pulmonary hypertension , with increasing the level of pulmonary hypertension the BNP will increase. BNP increasing had high association with the severity of heart failure.

Acute respiratory distress (ARD) is a critical respiratory failure due to lung injury of neonates leading to the clinical appearance of poor lung compliance. The aimed of the study was to evaluate the diagnostic values in differentiating respiratory from heart diseases with using of N-terminal pro brain natriuretic peptide (NT-pro BNP) and Atrial natriuretic peptide(ANP) in neonates.
Material and Ninety neonates randomly collected from those who hospitalized in the neonate ward of the Ali Ebne abitalib Hospital, Zahedan, Iran .After taking blood samples ANP and NT pro Brian Natriuretic peptide using ELISA kit were measured. The separated serum was kept in -20 °C until BNP measurement. 250 μl of the patients’ serum was isolated to assess pro BNP level using ELISA kit (USA). Data were analyzed using SPSS- 20 with considering of P NT pro-BNP level had the highest in cardiac patients and followed by respiratory. The level of NT pro-BNP for control neonates had the lowest. These levels had significant variation (P Many studies revealed that NT pro-BNP cannot be used as a tool for differentiation between cardiac and respiratory as a cause of respiratory distress during neonate, but the results of the present study showed that it would be good biomarker.

Heart disease is one of the leading causes of disability in major thalassemia patients. Timely diagnosis and effective treatment in these patients are essential. The aim of this study is to evaluate the diagnostic value of BNP in the diagnosis of heart involvement compared with echocardiographic findings in patients with major thalassemia. This case-control study was carried out in patients with major thalassemia aged 9-25 years old admitted to Aliasghar hospital from October 2010 to November 2011. Patients with no obvious cardiac abnormalities were included. 80 major thalassemia patients with 80 healthy children matched by age and sex were entered and for both, echocardiography was performed by a pediatric cardiologist. The serum level of Brain Natriuretic Peptides (BNP) was also evaluated. The data were analyzed by SPSS17. The groups studied were matched well regarding age and gender (P =0.1346, 0.429). Regarding the echocardiographic results, some of the parameters of the left heart in case group were significantly higher than control group as well as some of the parameters of right heart. The mean value of BNP in case group was higher significantly. There was a significant correlation between BNP and right heart MPI (r = 0.229, P = 0.041) and age (r = 0.237, P = 0.035). Based on the results, systolic and diastolic function in patients with major beta thalassemia were impaired. Therefore, measurement of BNP level in addition to serial echocardiography is recommended to early diagnose heart involvement in patients with major beta thalassemia without clinical symptoms.