جستجوی مقالات مرتبط با کلیدواژه "bowen's disease" در نشریات گروه "پزشکی"

Bowen’s disease (BD) is an in situ squamous cell carcinoma ofthe skin. Pigmented Bowen’s disease (pBD) is a rare variant,representing less than 2% of all BD cases. We report a case ofGiant pBD arising from seborrheic keratosis in a 65-year-old man.The dermoscopy showed a scaly surface, structureless brown togrey-black areas with dotted vessels, glomerular and reticulatevessels, and a few brown globules. Histopathology was classicalwith a “windblown appearance”; prominent melanophages wereseen in the dermis. Owing to the size and thickness of the plaque,a wide excision with a split-skin graft was done. The graft uptakewas good, and the patient was followed up on days 4 and 26post-surgery. We present our experience with the diagnosis andmanagement of this rare case of giant pBD. To the best of ourknowledge, such a case has not been previously reported.

Bowen’s disease (BD) is a non-melanoma skin cancer with several histological subtypes. Herein we describe a case of a 35-year-old woman with a 4-cm diameter crusted plaque on the parietal scalp region. She had the lesion for 2 years. It had previously been histologically diagnosed as pemphigus vulgaris and only treated with a topical cream. The lesion progressively became thicker and larger. A new biopsy showed atypical cell proliferation through the whole thickness of the epidermis and follicular epithelium, with dermal microinvasion along with acantholysis and clear cell formation. The patient underwent total lesion excision (1 cm margin) with the diagnosis of both acantholytic and pagetoid subtypes of BD and dermal microinvasion. We describe a rare case of a young female patient with both subtypes of BD present in one lesion on an area not exposed to the sunlight. The lesion was initially misdiagnosed as pemphigus vulgaris.

Bowen's disease (BD) is an epidermal in-situ squamous cell carcinoma (SCC). Most Human Papilloma Viruses (HPV)-positive lesions in Bowen's disease are localized to the genital region or distal extremities (periungual sites) in which HPV type-16 is frequently detected. Patient was a 64-year-old construction worker for whom we detected 2 erythematous psoriasiform reticular scaly plaques on peri-umbilical and medial knee. Biopsy established the diagnosis of Bowen's disease and polymerase chain reaction assay showed HPV-6, -18 co-infection. Patient was referred for surgical excision.

Bowen’s disease is a form of intraepidermal squamous cell carcinoma (SCC) characterised by a persistent, non-elevated, red, scaly or crusted plaque with a small potential for invasive malignancy. Most cases of typical Bowen’s disease in the white population are found on the lower legs of the elderly women. However, in this part of the world, i.e. Kashmir, the most common site is thighs followed by the lower abdomen. A range of treatment options are available for it including cryotherapy, curettage and cautery, photodynamic therapy, laser destruction, surgical excision, 5-fluorouracil cream, imiquimod cream, and radiotherapy. The aim of this study was to evaluate the efficacy of surgical excision in Bowen’s disease. All the patients with biopsy proven Bowen’s disease were included for the study. A detailed history was taken for each patient including the history of medical treatment for Bowen’s disease. Wide surgical excision (including either fusiform excision, W-plasty, or Z-plasty) was performed in each patient and the patients were then followed up for any recurrence. No sign of renewed disease activity at 6 months follow-up was taken as cure. All patients are intended to be followed up for 5 years. Ten out of 12 patients reported the use of topical imiquimod cream but complained of the progression of lesions. Surgical excision was performed in 12 patients. All the patients are currently under regular follow-up. Except for secondary infection and wound dehiscence in one patient, all the patients are in good condition with no signs of recurrence. Although it was a preliminary study, we recommend surgical excision in treatment of Bowen’s disease due to low recurrence rate.

Precancerous lesions are disorders that are highly likely to become malignant. Early diagnosis of precancerous skin lesions helps to prevent skin cancers. The aim of this study wasclinicopathological assessment of precancerous skin lesions in patients referred to the dermatology department of Imam Reza hospital.

Two hundred and nine patients who were diagnosed with precancerous lesions and referred to the dermatology department of Imam Reza hospital from 1997 to 2007 were studied. Study parameters included participants’ age, sex and occupation, type of precancerous skin lesion, clinicopathological type of the lesion and location. The data was collected from the patients’ records in the dermatology department and their microscopic slides inthe pathology department.

The most common precancerous skin lesion was actinic keratosis (68.4%) followed by Bowen’s disease (7.2%). About 67.5% of the patients were male with a mean age of 61.7 years. Moreover, 53.1% of the patients worked outdoors. The most common site of the lesions was head and neck (83.3%) and 18.7% of lesions were associated with malignancy. The most common pathological form of actinic keratosis was the proliferative type (28.9%).

The results of this study showed that precancerous skin lesions were more prevalent in men aged over 50 years, in sun-exposed areas and in occupations practiced outdoors. In addition to squamous cell carcinoma, these lesions could alsobe associated with basal cell carcinoma.