جستجوی مقالات مرتبط با کلیدواژه "chronic stable angina" در نشریات گروه "پزشکی"

جستجوی chronic stable angina در مقالات مجلات علمی

انتخاب همه

Rheumatoid factor, anti-nuclear antibody in ischemic heart disease: Acute versus chronic patients

Akram Sedaghat, Masoumeh Sadeghi, Ramin Heidari, Effat Sistani, Zahra Bayanfar

Arya Atherosclerosis, Volume:10 Issue: 6, Nov 2014, PP 305 -310

Background
Immunopathological and inflammatory processes play important roles in the initiation and development of ischemic heart disease. Hence, this study aimed to evaluate the relationship between serum levels rheumatoid factor (RF) and anti-nuclear antibodies (ANA) and severity of coronary stenotic lesions.
Methods
Totally 140 patients with acute coronary syndrome (ACS) (n = 70) and chronic stable angina (CSA) (n = 70) that undergoing coronary angiography were enrolled in this study. ANA by the enzyme-linked immunosorbent assay (ELISA) and serum level of RF was measured by latex method. The severity of coronary stenotic lesions calculated by Gensini score. To analyze the correlations of ANA and RF to Gensini score Pearson correlation test was used. To adjust the effect of age and other confounder factors such hypertension, diabetes, hyperlipidemia and smoking multiple linear regression was used.
Results
The mean serum levels of RF and ANA in CSA group were significantly higher than ACS group after adjusting for the confounder factors (P < 0.050 for ANA). Serum levels of ANA significantly correlated with severity of coronary stenotic lesions calculated by Gensini score (r = 0.40 and P < 0.050). After adjusting confounders, multiple linear regression analysis showed ANA remained independently associated with Gensini scores in ACS group (B = 0.505, P < 0.001).
Conclusion
Higher serum levels of ANA may be considered as independent risk factors for ACS.

Keywords: Rheumatoid Factor, Anti, Nuclear Antibodies, Acute Coronary Syndrome, Chronic Stable Angina, Gensini Score

Abstract View Paper Original: English
بررسی میزان سطح اسید اوریک سرمی و شدت درگیری عروق کرونر در آنژیوگرافی در بیماران مبتلا به chronic Stable Angina

مریم نباتی، محمدرضا شیران، زهرا اصفهانی، کیوان وسف نژاد، ولی الله حبیبی، مژده دبیریان، محمدصادق پارسایی، بابک باقری

مجله دانشگاه علوم پزشکی مازندران، پیاپی 98 (اسفند 1391)، صص 19 -26

سابقه و هدف
بیماری کرونری قلب (Coronary Artery Disease) اولین علت مرگ در جوامع امروزی و اولین علت مخارج بهداشتی فرد را تشکیل می دهد. عوامل خطر متعددی را برای ابتلاء به بیماری عروق کرونر مطرح می کنند که از جمله این ریسک فاکتورها بالا بودن سطح سرمی اسید اوریک به عنوان فاکتوری التهابی می باشد. بر همین اساس این مطالعه جهت بررسی میزان سطح سرمی اسید اوریک وشدت درگیری عروق کرونر در آنژیوگرافی در بیماران مبتلا به Chronic Stable Angina با در نظر گرفتن و ادجاست سایر ریسک فاکتورها مانند سن- سیگار- هایپر تنشن- هایپر لیپیدمی- دیابت انجام شده است.
مواد و روش ها
این مطالعه به صورت cross-sectional تحلیلی جهت بررسی سطح اسید اوریک سرمی و شدت درگیری عروق کرونر در آنژیوگرافی در 201 بیمار مبتلا به آنژین صدری مزمن صورت گرفته است. سایر عوامل خطر شایع بیماری قلبی عروقی نیز شامل دیابت، فشارخون، هایپرلیپیدمی، سن و مصرف سیگار نیز در بیماران ثبت و در بررسی ارتباط در نظر گرفته شدند.
یافته ها
در این مطالعه بیماران شامل 78 بیمار زن (39 درصد) و 123 مرد (61 درصد) بودند. عوامل خطر شامل دیابت، فشار خون، سن، هایپرلیپیدمی و اسید اوریک در دو جنس مرد و زن تفاوت معنی داری نداشته است. میانگین شدت درگیری کرونر در بیماران مورد مطالعه 7/10±8/15 بوده و میانگین سطح اسید اوریک mg/dl 0/6 ± 5/10 بوده است که ارتباط مثبت و معنی داری بین آن ها هم در زنان و هم در مردان وجود داشته است (ضریب همبستگی pearson= 510/0، 0001/0>p، ضریب pearson=537/0، 0001/0>p). همچنین ارتباط معنی داری بین شدت درگیری عروق کرونر با پرفشاری خون، سن و سابقه دیابت و هایپرلیپیدمی وجود داشت. آنالیز آماری چندگانه نیز نشان داده است که 15 درصد این تغییرات مربوط به اسید اوریک می باشد.
استنتاج
با توجه به یافته های این مطالعه، به نظر می رسد که بین سطح اسید اوریک سرم و شدت CAD ارتباطی مستقل وجود داشته باشد.

کلید واژگان: آنژین صدری مزمن, بیماری عروق کرونر, اسید اوریک سرم

چکیده مشاهده متن زبان: فارسی

Relationship between the Level of Serum Uric Acid and Severity of Coronary Artery Atherosclerosis Determined by Coronary Angiography in Patients with Chronic Stable Angina

Maryam Nabati, Mohammadreza Shiran, Zahra Esfahani, Keyvan Yousefnejad, Valiollah Habibi, Mozhde Dabirian, Mohammadsadegh Parsaee, Babak Bagheri

Journal of Mazandaran University of Medical Sciences, Volume:22 Issue: 98, 2013, PP 19 -26

Background and
Purpose
Coronary artery disease (CAD) is the first cause of death in modern societies. It is also the first cause for individual health care cost. Multiple risk factors are mentioned for its development among which elevated uric acid is recently introduced as an inflammatory factor. This study was performed for evaluating the serum uric acid level and severity of CAD determined by coronary angiography in patients with chronic stable angina after considering and adjusting other risk factors such as age, smoking (C.S), hypertension (HTN), hyperlipidemia (HLP) and diabetes mellitus (DM).
Materials And Methods
This cross-sectional analytic study was performed in 200 patients with chronic stable angina to determine the relationship between the level of serum uric acid and severity of coronary atherosclerosis in angiography. Other common cardiovascular risk factors including age, DM, HTN, HLP and C.S were also considered.
Results
A total of 78 women (39%) and 123 men (61%) were included in the study. There were no significant differences between sex and risk factors including DM, HTN, HLP, C.S, age and serum uric acid level. In the studied population, the mean severity of coronary atherosclerosis score measured by Gensini score was 15.8± 10.7 and the mean level of uric acid was 10.5±6mg/dl. Significant correlation was seen in severity of coronary atherosclerosis and level of serum uric acid in the study population (r=0.51, 0.537, respectively P<0.0001). Also, there was significant correlation between coronary atherosclerosis severity and HTN, age, DM and HLP. Multivariate analysis showed 15% contribution of serum uric acid level in developing coronary atherosclerosis.
Conclusion
This study showed an independent relationship between serum uric acid level and severity of coronary atherosclerosis.

Keywords: Chronic Stable Angina, coronary artery disease, serum uric acid

Abstract View Paper Original: Persian
The relation between lipoprotein (a) levels and findings of coronary artery angiography

Mansour Sholehvar, Hamid Sanei, Yeganeh Satei

Arya Atherosclerosis, Volume:7 Issue: 5, Winter 2012, P 70

Background
Lipoprotein (a) (LP (a)) has been identified as one of the independent risk factors for coronary artery diseases. Various studies on the amount of serum LP (a) with relation to intensity and extent of observed lesions on coronary angiography have yielded in different results. Therefore, this study aimed to examine the importance of LP (a) levels and its relationship with the findings of coronary artery angiography.
Methods
The present research was conducted by considering clinical symptoms, level of serum lipids and amount of LP (a) in 92 patients who were under angiography because of chronic stable angina. The angiography was performed in a standard way with conventional views and was interpreted by at least two cardiologists.
Results
The levels of LP (a) were considerably higher in the group with two-vessel coronary artery lesions (55 ± 45 mg/dl) as compared with the patients with one-vessel (30.3 ± 27 mg/dl) or three-vessel diseases (26.9 ± 15 mg/dl). The statistical analysis of the results in these three groups demonstrated that there was no relationship between the levels of serum LP (a) and intensity of observed lesions on the coronary angiography.
Discussion
Although a few studies have reported a statistical relationship between the serum levels of LP (a) and intensity of observed lesions on coronary angiography, similar to numerous other researches, such a relationship was not observed in the present study. However, the findings of this study confirm that LP (a) should be considered as a risk factor for early coronary artery diseases.

Keywords: Lipoprotein (a), Coronary Artery Angiography, Chronic Stable Angina, Risk Factors

Abstract View Paper Original: English

نکته

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جستجوی مقالات مرتبط با کلیدواژه "chronic stable angina" در نشریات گروه "پزشکی"