جستجوی مقالات مرتبط با کلیدواژه « ciprofloxacin hydrochloride » در نشریات گروه « پزشکی »
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Background
Ciprofloxacin (CIP) is a broad-spectrum antibiotic, used to treat various bacterial infections. Administration of conventional oral dosage forms of CIP is associated with multiple challenges such as short residence time of the drug in the gastrointestinal tract which could reduce bioavailability and effectiveness of the drug. This study aimed to design and develop novel floating microspheres for the sustained release of CIP in the stomach over 24 hours after oral administration, besides evaluating the effect of different variables on the characteristics of developed microspheres.
MethodsMicrospheres were developed by the solvent-evaporation method utilizing cellulose acetate and polyvinyl alcohol, then characterized for physicochemical properties including bulk density, buoyancy, and entrapment efficacy. The drug-excipient compatibility was evaluated by Fourier-transform infrared spectroscopy and the Scanning electron microscopy was used to observe the morphology of microspheres. The effects of the drug to polymer ratio, polymer concentration, and the pace of stirring through the preparation process, on the size and release rate were also evaluated.
ResultsMorphology analysis indicated round-shape microspheres with a mean particle size between 66-344 µm. The polydispersity index of prepared formulations was determined to be in the range of 0.129 to 0.230. It was observed that at higher polymer concentrations the drug release rate from microspheres decreased while the mean particle size increased. Increasing the drug to polymer ratio and decreasing the stirring speed increased the mean particle size. All formulations showed more than 70% cumulative drug release in the prolonged period of 24 h while remaining buoyant in the meantime. The formulations followed Higuchi and Korsmeyer-Peppas kinetics and release the drug by diffusion mechanism.
ConclusionBased on the results obtained from in vitro release study besides floating properties, the prepared microspheres could be considered suitable for enhanced sustained-release of CIP following the oral administration.
Keywords: Ciprofloxacin hydrochloride, Cellulose acetate, Floating microspheres, Gastro-retentive drug delivery systems, Solvent-evaporation} -
زمینه و هدفهدف از این تحقیق، تهیه نانو الیاف سلولزی با پایه سبوس گندم به عنوان یک پسماند کشاورزی و ارزیابی اثر ضدمیکروبی آن با آغشته سازی داروی سیپروفلوکساسین هیدروکلراید بر روی باکتری استافیلوکوک اورئوس بود.مواد و روش هادر این مطالعه تجربی، ابتدا دیسک های سلولزی از نانو الیاف آغشته به دارو آماده شدند. سپس این دیسک ها به همراه دیسک های کاغذی استاندارد بر روی محیط استافیلوکوک اورئوس قرار گرفتند. نتایج به صورت هاله عدم رشد پس از 24 ساعت اندازه گیری گردید. تعیین میزان سیپروفلوکساسین هیدروکلراید جذب شده بر روی نانوالیاف سلولزی با مقایسه اثر دیسک های سلولزی حاوی غلظت های مختلف آنتی بیوتیک و دیسک های استاندارد سیپروفلوکساسین صورت گرفت. مدت زمان بهبودی زخم سطحی در پوست رت با پانسمان نانو الیاف آغشته به دارو و بدون دارو مقایسه گردید.یافته هادیسک (نانو آلفاسلولزی) آغشته به داروی سیپروفلوکساسین هیدروکلراید، هاله عدم رشد در محیط استافیلوکوک اورئوس ایجاد کرد. اندازه گیری ابعاد زخم با عکس برداری دیجیتال و نرم افزار ImageJ انجام گرفت. نتایج حاصل از روند بهبودی طی پنج روز با آزمون آماری آنووا و آزمایش پاتولوژی تحلیل شد.نتیجه گیرینتایج نشان داد که دیسک نانوالیاف سلولزی در محیط کشت برای کنترل باکتری می تواند مفید باشد. هم چنین مساحت زخم ها در رت هایی (موش هایی) که با دیسک های نانو الیاف آغشته به دارو پانسمان شدند به صورت معنی داری کم تر از گروه شاهد بود (05/0> p).کلید واژگان: آلفاسلولز, الکتروریسی, سیپروفلوکساسین هیدروکلراید, رت}Background and AimThe purpose of this research is to provide nanofibers from cellulose with Wheat bran as an agricultural residue and its antimicrobial activity by dipping ciprofloxacin hydrochloride on Staphylococcus aureus.Materials and MethodsIn this experimental study, cellulose disks were prepared from nano-impregnated fiber. Subsequently, these disks were placed on Staphylococcus aureus with standard paper disks and the results were measured as a non-growth zone after 24 hours. The amount of ciprofloxacin hydrochloride adsorbed in cellulose by comparing the effect of cellulosic discs containing different concentrations of antibiotics and standard ciprofloxacin disks was determined. Subsequently, the evaluation of the time of recovery of the ulcer in the skin of the rats was carried out with the drug-mediated formulation and without drug.
Findings: The disk (nano alpha-cellulosic) dipped by ciprofloxacin hydrochloride created a non-growth zone in Staphylococcus aureus. Measuring the size of the wound was done by digital imaging and the ImageJ software. The results of the recovery process were analyzed by ANOVA and pathological tests in five days.ConclusionThe results showed that the nano-fibers disk could be useful in controlling bacteria in the culture medium, and the area of the wounds in rats (rats) dressed with nano-fibers impregnated with the drug was significantly less than the control group (p <0.05)Keywords: Alpha cellulose, Electrospinninig, Ciprofloxacin hydrochloride, Rat} -
PurposeFloating drug delivery system reduces the quantity of drug intake and the risk of overloading the organs with excess drug.MethodsIn the present study, we prepared the blends of sodium alginate with polyethylene glycol (PEG) and polyethylene oxide (PEO) as a matrix, sodium hydrogen carbonate as a pore forming agent, methyl cellulose as a binder and barium chloride containing 10% acetic acid as a hardening agent. Different ratios of pore forming agent to the polymer blend was used to prepare the floating beads with different porosity and morphology. Ciprofloxacin hydrochloride was used as a model drug for the release kinetics studies.ResultsThe beads were characterized by optical and FESEM microscopy to study the morphology and pore dimensions. The results obtained shows decrease in beads size with increase in the concentration of the pore forming agent. The swelling properties of the beads were found to be in the range of 80% to 125%. The release kinetics of the ciprofloxacin from the beads was measured by UV-Visible spectroscopy at λmax of 278nm and the results shows for highly porous beads.ConclusionBy varying the amount of alginate and pore forming agent the release kinetics is found to get altered. As a result, ciprofloxacin hydrochloride release is found to be sustained from the blended beads.Keywords: Ciprofloxacin hydrochloride, Floating drug delivery system, Polyethylene glycol, Polyethylene oxide, Sodium alginate, Sodium bicarbonate}
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