جستجوی مقالات مرتبط با کلیدواژه « clinical findings » در نشریات گروه « پزشکی »

Ongoing methadone intoxication parallels the generalization of the implemented addiction cession programs, as well as the necessity to sustain an effectively durable addiction treatment course. This study aimed to investigate the predisposing factors and clinical features of methadone intoxication.

During a one-year period (March 2018 to March 2019), patients admitted for methadone intoxication were investigated retrospectively. Demographic data, the consumed methadone dose, electrocardiogram findings, and the level of creatinine phosphokinase (CPK) at admission were collected and entered into a statistical analyzing platform (SPSS version 22) for further statistical testing.

Seventy-five eligible patients were investigated. The mean age was 23.63±16.66, 66.7% were male, and 15 patients were children. The unemployment status led to an increased methadone poisoning (MP) incidence (P<0.05). The incidences of an increased CPK or QT segment prolongation were 17% and 7%, respectively. There was not any statistical correlation between the incidence of MP, the demographic and clinical data, as well as the used methadone dose. Moreover, the duration of the QT segment was not statistically influenced by the CPK.

MP incidence seems to be influenced by social status. The increase in CPK and QT prolongation was not influenced by the methadone dose. It seems that more studies are required to further investigate the risk and prognostic factors of MP.

Placenta accreta is one of the known causes of maternal mortality and morbidity. If diagnosed before delivery, appropriate actions can be taken. The aim of this study was to investigate the role of scaling combination of risk factors in predicting placenta accreta spectrum (PAS).

In this cross-sectional study, 120 pregnant women with two criteria and more of placenta previa in their ultrasound, underwent MRI. Clinical scores (history of surgery, cesarean section, previa, etc.) and paraclinical scores (ultrasound and MRI) were recorded and combined. In cases of hysterectomy, pathological examination was performed. The results were compared and analyzed using SPSS Version 22. The significance level was less than 0.05.

Of the120 studied patients, 90 (75%) women were diagnosed with placenta previa in which, 32(36%) patients had placenta accreta and 12 patients had placenta accreta without placenta previa. The mean ultrasound score in women without and with placenta accreta were 0.05±0.32 and 2.43±1.83 (p<0.001). The mean MRI score in women without and with placenta accreta were 0.05±0.27 and 2.07±2.02, respectively. The cut-off point, sensitivity and specificity were 0.50, 100% and 93.4%, respectively. The mean clinical score without and with placenta accreta were 1.97±1.32 and 4.89±3.21, respectively. The cut-off point, sensitivity and specificity were 2.50, 70% and 80%, respectively. The cut-off point of combination score, sensitivity and specificity were 3.50, 89%, 83%.

The results of the present study showed that the most specific test to confirm the definitive diagnosis of placenta accreta is paraclinical score, alone.

Baclofen overdose acutely affects the nervous system and induces a decrease in the consciousness level, coma, and death. The diagnosis of it is based on the patient’s history and clinical findings.

The present study aims to investigate baclofen-induced poisoning based on medical reports in a 5-year period.

This retrospective study was conducted in Loghman Hakim Hospital, Tehran, Iran. The medical profile of 135 patients with baclofen overdose was read out, collected, and analyzed using SPSS version 18.

The average age of 135 patients was 26.37±18.73 years. The majority of them were female (68.1%) and intentional attempts (66.7%). There were 117 patients (86.7%) with central nervous system symptoms. The most common nervous finding was drowsiness (n = 53, 45.3%). There was no patient with seizures. There was a significant statistical relationship between the dose of baclofen and consciousness level (GCS ≤12: 302.61 ± 236.40 mg, and GCS >12: 162.21 ± 121.02 mg, P < 0.001).

Baclofen overdose should be considered in patients referred to the emergency department with drowsiness symptoms and decreased consciousness level. Because of this poisoning, it has no specific symptoms and is common in female and young people.

Background:

 In 2019, an unknown disease called coronavirus disease 2019 (COVID-19) began to spread in China. The disease is now widespread in almost all countries and has endangered the lives of many people. For this reason, a systematic review and meta-analysis were conducted with the aim of assessing the clinical characteristics of the disease in children and adolescents with COVID-19.

This systematic review and meta-analysis have been conducted by reviewing most of the epidemiologic studies on the worldwide prevalence of COVID-19 in children and adolescents. The following international databases were used: EMBASE, Scopus, Web of Science, PubMed/Medline, Science Direct, and the Google Scholar Search Engine. The keywords used for searching included "child", "pediatric", "adolescents", "COVID-19", "Coronavirus", and "diagnosis”. The data were analyzed using STATA statistic software version 11.0.

The total number of patients was 2579, of which 1467 (56.9%) were male and 1110 (43.1) were female.All patients were in their childhood and adolescence years. At the beginning of the research, 1356 studies were reviewed, of which 987 entered the next reviewing stage. Finally, 14 studies were selected for the systematic review and meta-analysis. The prevalence of fever in children and adolescents was 55.0% (95% CI 0.55 [0.40, 0.70]), of cough 41.0% (95% CI 0.41 [0.27, 0.56]), of nasal discharge 9.0% (95% CI 0.09 [0.05, 0.12]), and of diarrhea 5.0% (95% CI 0.05 [0.02, 0.08]). 

Conclusion :

The results of this study can be a guide for pediatricians and specialists in the field of infectious diseases to identify the clinical signs of COVID-19 in children and adolescents.

Spitz Nevus is an infrequent acquired melanocytic nevus. There is still a challenge for dermatopathologists in dis- tinguishing spitz nevus from malignant melanoma particularly in adults since there is no immunohistochemistry or molecular markers which differentiate Spitz Nevus frommelanoma.

The aim of this study is to make clear what clinico-histopathological features of Spitz Nevus are in order to reduce malpractice due tomisdiagnosis.

In the present study, a series of twenty two patients have been reviewed who were diagnosed with Spitz Nevous based on proved histopathology features between the years 2009 - 2013. The patients were evaluated for demographic parameters like age, sex, clinical differential diagnosis, cutaneous location of tumor, tumor diameter, subtype, symmetry,maturation, upper cleft- ing of melanocytic nest, shoulder phenomena, epidermal hyperplasia, type, kamino body,mitotic rate , inflammatory infiltration, pagetoid spread and regression.

In our study, 45% of patientswere younger than 10 years old. The average age of patientswas 1411.37. Male to female ratio was 1.44. The commonest location was head and neck. Spitz nevus was the first clinical differential diagnosis in 20% of patients. The commonest variant type was conventional type and then polypoid and desmoplastic types. The mean size of nevi was 0.81  0.59mm. About 59% of nevi shows epithelioid cytologic features. Other histologic parameters fromthemost to the least frequency were symmetry (100%), maturation (100%), epidermal hyperplasia (77.3%), kamino body (68.2%), subtype (compound 68%), mitotic rate (63.6%), clefting (59%), inflammatory infiltration (54.5%), pagetoid spread (18.2%), shoulder (37.5%) and regression (9.1%).

We tried to hifhlight some clinical and histopathological features which are distinguishing Spitz nevus from other melanocytic nevi evenmalignantmelanoma.