جستجوی مقالات مرتبط با کلیدواژه "creatinine ratio" در نشریات گروه "پزشکی"

Context: Diabetic nephropathy is a common complication of diabetes mellitus with a higher incidence. Renin-angiotensin system blockers, as the main treatment for patients with diabetic kidney disease, can not only reduce albuminuria, but also lead to hyperkalaemia and creatinine. Therefore, additional protective therapeutic interventions are needed.
Evidence Acquisition: An electronic literature search was conducted in international and domestic databases including PubMed, Embase, CNKI, Scopus, Index Copernicus, DOAJ, and Wanfang database for trials up to January 2017. The search terms used were as follow: "Diabetic Nephropathies", "vitamin D3", "Cholecalciferol", "Calcitriol", "Alfacalcidol", "Paricalcitol", and "Randomized Controlled Trial". Quality assessments were evaluated with the Newcastle-Ottawa Quality Assessment Scale. Data were extracted by 2 independent reviewers (TJL and WGL). For all analysis, the standard mean difference (SMD) or odds ratio (OR) with 95% confidence intervals (CIs) were calculated, and heterogeneity of the studies was analyzed using I2 statistics.
Twenty-four studies were (1,978 patients) identified in the literature retrieve process. The assessment scores indicated that all the admitted studies were reliable with scores ranging from 6 to 9. The pooled results indicated that vitamin D3 had a significant effect in reducing albuminuria (MD = -0.23, 95% CI: -0.30, -0.15) and that the vitamin D3 group had a low ratio of urinary microalbumin to creatinine than the control group (SMD = -0.49, 95% CI: -0.90, -0.08). The results also revealed that vitamin D3 group had a lower hs-CRP than the control group (MD = -0.80, 95% CI: -1.26, -0.34).
Based on the evidence of this study, vitamin D3 could be suggested as a recommended drug for patients with diabetic nephropathy in clinical practice.

The aim of the study was to compare albumin to creatinine ratio (ACR) in the morning urine sample with the 24-hour urinary albumin excretion in diabetic patients by using facilities available in Iran, also determining correlation between them and day to day variation of ACR.
In this 8-month long cross-sectional study conducted in the year ending on 20 March 2006 in Zanjan, a 24-hour collected urine sample and 2 single morning samples were evaluated for measuring albumin by use of immune-turbidometry in 201 outpatients afflicted with diabetes mellitus type 2. The correlation coefficient of ACR in single samples and 24-hour urinary albumin excretion samples were assessed by use of Pearson correlation statistical test, and the regression analysis and its diagnostic function in diagnosing of micro-albuminuria.
Fifty one out of 201 patients (25.40%) had micro-albuminuria and 8 (4%) were afflicted with macro-albuminuria. The correlation coefficient of ACR was maximally 81% (P Until more assessment of other available laboratory kits is made, the morning urine albumin/creatinine ratio test will not be an acceptable alternative for measuring 24-hour urine albumin in diagnosis of micro-albuminuria in diabetic patients in Iran.

Considering that gestational hypertension may have severe effects on the mother and fetus, this study was conducted to examine the nutritional status of pregnant women and urine calcium-to-creatinine ratio during 24th - 28th weeks of pregnancy and their relationship with the incidence of hypertensive disorders during pregnancy.
This prospective longitudinal study recruited 538 pregnant women attending prenatal clinics in Tehran, Iran in 2011. A food frequency questionnaire (FFQ) was completed for all mothers at the baseline for nutritional intake assessment, and a random urine sample was taken between 24th - 28th weeks of pregnancy to calculate the Ca/Cr-ratio. Hypertensive disorders were classified into two groups: a, gestational hypertension in case of detecting a blood pressure ≥ 140/90; and b, preeclampsia in case of increased proteinuria. Data were analyzed using SPSS V.16 and N4 software programs.
In this study, 14 (6.2%) pregnant women had hypertensive disorders during pregnancy. The desired nutritional status and Ca/Cr-ratio had no significant relationship with hypertensive disorders during pregnancy. The regression test was used to investigate the variables affecting hypertensive disorders, which showed the significant relationship of pre-pregnancy BMI and mother’s age with hypertensive disorders during pregnancy (P ≤ 0.05).
In this study, the incidence of hypertensive disorders had no relationship with the Ca/Cr-ratio and the nutritional status of the pregnant women. However, since more than 80% of the participants had undesirable nutrition, mothers’ nutrition in the first half of pregnancy is necessary to be under observed.