جستجوی مقالات مرتبط با کلیدواژه « das28 » در نشریات گروه « پزشکی »

Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease characterized by synovitis, inflammation, and joint destruction that if not well controlled can destroy cartilage, bone, ligaments and tendons, and in some cases cause disability. The aim of this study was to evaluate the possible role of the ratio of neutrophil-lymphocyte (NLR) as an inflammatory marker in determining the severity of RA (Disease Activity Score 28 [DAS28]).

Fifty patients with RA attending the rheumatology clinic in Ilam Shahid Mostafa Khomeini Hospital, Iran, were examined for disease activity using physical and laboratory tests. NLR and disease severity were determined based on DAS28.

The disease activity, including remission and mild/moderate were seen in 34% (DAS28<2.6) and 66% (DAS28 2.6), respectively. The patients were 86% women and 14% men. Mean ages of patients with mild/moderate and remission RA were 51.30 and 36.82 years, respectively. The mean NLR was 1.80 in patients with remission RA and 1.93 in those with mild/moderate RA and no significant relationship was found in NLR between these two groups (P=0.99). There was a significant relationship between DAS28 and erythrocyte sedimentation rate (ESR) (P=0.02), and a weak relationship between DAS28 and age, gender, and medication (P≥0.1).

According to the results, perhaps ESR rather than NLR could be a prognostic factor for determining disease activity levels in RA patients with DAS28 <3.2.

Rheumatoid arthritis (RA) is an autoimmune disease with unknown origin. Several etiologic factors have been attributed to the pathogenesis of RA, which is substantially derived by inflammatory factor. Trace elements (TE) including selenium, zinc and copper are components of several fundamental enzymes in the oxidative pathways which play crucial role in the prevention of cellular oxidative stress induced by superoxides and free radicals. The current study aimed to assess the relationship between serum values of the trace elements and RA disease activity. On this purpose, searching of available electronic databanks by relative keywords and without any time limitation performed. The serum levels of selenium, zinc, and zinc/copper ratio in patients with RA were lower than those values in age- and sex-matched healthy control individuals; but zinc had a positive correlation with serum levels of albumin and negative relation with disease duration. Furthermore, copper was positively correlated to disease activity and there was no association between serum level of copper and age or gender. There was a relationship between lower values of selenium and number of affected joints in RA. It can be concluded that there is a relationship between serum values of trace elements and RA development and disease activity.