جستجوی مقالات مرتبط با کلیدواژه « endodontic sealers » در نشریات گروه « پزشکی »
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Introduction
One of the most common problems in endodontic treatments is post-treatment pain, and sealers might be one of the factors influencing the degree of pain following root canal therapy. The purpose of this study is to compare pain following endodontic treatment using an AH-26 resin sealer against the Resil experimental sealer in mandibular molars with irreversible pulpitis.
Materials and MethodsOne hundred patients with irreversible pulpitis in the mandibular first or second molar were randomly divided into two groups (n=50) based on the type of sealer applied. Two postgraduate students with at least five years of experience treated all patients. All patients had a single root canal treatment. Postoperative pain scores and analgesic consumption were assessed after 6, 12, 24, and 48 hours and 3, 4, 5, 6, and 7 days after the treatment. The data were statistically analyzed by Fisher's exact or Chi-Square test (to compare the distribution of qualitative variables in two groups), repeated measures ANOVA (to compare changes in pain intensity over time in two groups), Boneferronie (for pairwise comparisons), Friedman, Wilcoxon and Mann-Whitney tests (for assessment of the changes in pain scores over time). The generalized estimating equations (GEE) were used for assessing time and group effects.
ResultsThere was no significant difference in postoperative pain between groups at any of the time points studied (P>0.05), and also for patient analgesic consumption between groups (P>0.05). Both groups recorded the maximum pain levels in the first 6 hours. For each subsequent day postoperatively, the odds ratio (OR) of not using analgesics was 2.078.
ConclusionResil and AH-26 perform similarly in terms of the occurrence and intensity of postoperative pain in mandibular molar teeth with irreversible pulpitis.
Keywords: AH-26, Endodontic Treatment, Endodontic Sealers, Resi} -
IntroductionThis study aimed to assess the cytotoxicity of Duraflur fluoride varnish as root canal sealer against L929 mouse fibroblasts in comparison with four commonly used conventional endodontic sealers in the first 48 hours of exposure.MethodsIn this in vitro, experimental study, L929 mouse fibroblasts were exposed to 1/1, ½, ¼ , and 1/8 concentrations of Duraflur fluoride varnish, AH Plus, Fill Canal, MTA Fillapex, and AH26 sealers. After 48 hours, the methyl thiazolyl tetrazolium (MTT) assay was performed to assess the cytotoxicity of sealers. Cell viability was determined as the percentage of viable cells compared with the control group. The results were analyzed using one-way ANOVA followed by the Tukey’s post hoc test for multiple comparisons..ResultsMTA Fillapex had the lowest and AH26 had the highest cytotoxicity (p <0.05). Fluoride varnish showed high cell viability in 1/8 concentration (91.09%). Its cytotoxicity was close to that of AH Plus with no significant difference (P=0.49) but it had higher cytotoxicity than Fill Canal and Fill Apex (p <0.05). Fluoride varnish in 1/1 and 1/8 concentrations showed significantly higher cell viability than AH26 (p <0.001).ConclusionFluoride varnish sealer has acceptable biocompatibility comparable to that of conventional sealers. It has lower cytotoxicity than AH26.Keywords: Cytotoxicity, Endodontic Sealers, fluoride varnish, Methyl Thiazolyl Tetrazolium Assay}
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IntroductionMicroorganisms and microbial products are the main etiologic factors in pulp and periapical diseases. The present study aimed to compare the antifungal activity of two different sealers, AH-26 and MTA Fillapex against three strains of Candida, 24, 48, 72 h and 7 days after mixing.
Methods and Materials: The microorganisms used in this study were Candidia albicans (ATCC 10231), Candidia glabrata (ATCC 90030) and Candidia krusei (DSM 70079). This test was based on growth of microorganisms and turbidity measurement technique using a spectrophotometer. The direct contact test was conducted by direct and indirect methods. Multiple comparisons were carried out using analysis of variances (ANOVA) with repeated measures followed by Tukeys tests.ResultsThe antifungal activity of both sealers was similar in the indirect method. The antifungal activity of both sealers in the direct method was similar against Candida albicans and higher for AH-26 sealer against Candida krusei and Candida glabrata.ConclusionThe total antifungal effect of MTA Fillapex sealer was significantly less than AH-26 sealer in direct method. The antifungal effect of both sealers was similar in indirect method.Keywords: Antifungal, Antimicrobial, Candida, Endodontic Sealers} -
Statement of Problem: Adhesion to root canal dentin is one of the necessary characteristics of endodontic sealers. MTA Fillapex (Angelus, Londria, PR, Brazil) is one of the recently introduced MTA-based sealer. Only a limited number of studies have evaluated the bonding of this sealer to the dentin, with conflicting results.ObjectivesThe purpose of this study was to evaluate the bond strength of MTA Fillapex sealer) to root canal dentin compared to an epoxy resinbased sealer (AH26 sealer).Materials And MethodsTwenty root blocks (6mm length) were acquired from the middle part of the extracted single-rooted central or lateral maxillary incisor roots and their lumens were enlarged to achieve a diameter of 1.3 mm. MTA Fillapex and AH26 were placed in the lumens of root blocks (n = 10). The specimens were kept in an incubator for 7 days, the roots were sectioned perpendicular to their long axis to achieve slices with thickness of 1 mm and the push-out test was carried out by a universal testing machine.ResultsThe mean value of bond strength was 1.84 ± 0.7 Mpa for AH26 and 0.19 ± 0.1 Mpa for MTA Fillapex. The difference between the two groups was statistically significant (p < 0.001).ConclusionsWith in the limitation of this study, AH 26 showed significantly higher bond strength in comparison to MTA Fillapex.Keywords: Endodontic Sealers, MTA, Push, out Bond Strength}
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مقدمهاز مهم ترین ویژگی سیلرهای درمان ریشه، خاصیت زیست سازگاری آن ها می باشد. هدف از انجام این مطالعه، بررسی میزان سمیت سلولی سیلرهای ADSEAL، tgsealer، AH 26 و MTA Fillapex به صورت آزمایشگاهی بر روی سلول های فیبروبلاست لثه ای انسانی بود.مواد و روش هادر این مطالعه ی تجربی آزمایشگاهی سیلرها در دو حالت تازه تهیه شده و سفت شده مورد بررسی قرار گرفتند. جهت بررسی سمیت سلولی، هر کدام از نمونه ها به صورت جداگانه در RPMI-1640 (Sigma-aldrich، USA) عصاره گیری شدند. عصاره های حاصله 1، 3 و 7 روز در تماس با سلول های فیبروبلاست رده C165 در محیط کشت قرار گرفتند. سپس میزان سمیت سلولی به روش رنگ سنجی (2،5-Diphenyltetrazolium Bromide) (4،5-Dimethylthiazol-2-Yl) MTT-3 و براساس میزان جذب نوری ارزیابی شد. برای آنالیز داده ها از آزمون آماری آنالیز واریانس چند طرفه و نرم افزار SPSS نسخه 5/11 استفاده گردید (05/0 = α).یافته هادر این مطالعه همه ی سیلرها دارای سمیت سلولی بودند. با توجه به آزمون آماری، اختلاف معنی داری بین میزان سمیت سلولی سیلرهای AH 26 (0/28 = p value) در حالت تازه تهیه شده و سفت شده وجود داشت ولی در مورد سیلرهای ADSEAL (0/910 = p value)، MTA Fillapex (0/952 = p value) و tgsealer (0/566 = p value) بین این دو حالت اختلاف معنی داری وجود نداشت. هم چنین با توجه به میانگین کلیه ی داده های به دست آمده از هر سیلر، کم ترین سمیت سلولی را MTA Fillapex (0/78) و بیش ترین سمیت سلولی را ADSEAL (0/60) نشان داد.نتیجه گیریبا توجه به محدودیت های این مطالعه، از بین سیلرهای مورد بررسی، سیلرهای MTA Fillapex و ADSEAL به ترتیب دارای کم ترین و بیش ترین میزان سمیت سلولی رتبه بندی شدند.
کلید واژگان: سمیت سلولی, فیبروبلاست, زیست سازگاری, سیلر معالجه ریشه}IntroductionBiocompatibility is one of the most important properties of endodontic sealers. The aim of the current study was to investigate the cytotoxicity of four endodontic sealers (AH26، MTA Fillapex، tgsealer and ADSEAL) on human gingival fibroblasts in vitro.Materials And MethodsIn this in vitro experimental study، four endodontic sealers were evaluated in fresh and set states. The fresh and set specimens were separately extracted in RPMI-1640 (Sigma-Aldrich، USA). The extracts were placed for 1، 3 and 7 days in close contact with C165 human gingival fibroblast in cell culture. Then the samples cytotoxicity was assessed by MTT assay (3-(4،5-dimethylthiazol-2-Yl) -2،5-diphenyltetrazolium bromide) and spectrophotometric analysis. Data were analyzed with multivariate analysis of variance using SPSS 11. 5 (α=0. 05).ResultsThe results showed that all the sealers were cytotoxic. According to statistical analysis a significant difference was seen between fresh and set specimens in AH26 (p value = 0. 028) but there were no significant differences in ADSEAL (p value = 0. 910)، MTA Fillapex (p value = 0. 952) and tgsealer (p value = 0. 566) between the two sealer states. In addition، based on means of all the data of each sealer MTA Fillapex (0. 78) had the least cytotoxicity and ADSEAL (0. 60) had the highest cytotoxicity.ConclusionIt can be concluded under the limitations of the present study that among the sealers evaluated in the present study MTA Fillapex and ADSEAL had the highest and lowest cytotoxicity، respectively.Keywords: Biocompatibility, Cytotoxicity, Endodontic sealers, Fibroblast} -
IntroductionAntibacterial activity is one of the desirable properties of an ideal sealer. This study aimed to compare the antimicrobial effect of three different sealers, i.e. resin (AH26), calcium hydroxide (Apexit) and zinc oxide eugenol (ZOE) based sealers.Materials And MethodsDirect contact test with agar diffusion was used in this in vitro study. The freshly mixed sealers were AH26, Apexit and pure ZOE. They were prepared according to manufacturer’s instruction and placed in prepared wells of 30 agar plates inoculated with Streptococcus (S) mutans and Prevotella (P) melaninogenicus (15 samples for each microorganism). All plates were incubated for 7 days (196 hours) at 37˚C under anaerobic conditions, and zones of inhibition were measured after 3 days, 5 days and 7 days. The data were analyzed using Kruskal-Wallis and Friedman tests.ResultsIn all determined intervals, the antibacterial activity of AH26 was significantly greater than other test materials (P<0.001). ZOE sealer had moderate effect on test microorganisms, whilst Apexit showed the lowest antibacterial activity on S. Mutans and no antibacterial activity on P. melaninogenicus.ConclusionThe ascending sequence of bacterial growth inhibition zones was as AH26>Pure ZOE>Apexit.Keywords: AH26, Antibacterial activity, Apexit, Endodontic sealers, ZOE sealer}
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Introduction
The materials used for obturation of root canal system may be extruded through apical foramen into the periapical tissue. Therefore, biocompatibility of these materials is very important. The purpose of this study was to evaluate the in vivo biocompatibility of three conventional endodontic sealers: AH26, Roth 801, and ZOE after their subcutaneous implantation in rats.Methods
Twenty-two mature male Albino rats, weighting from 250 to 500grs were used. Each animal received four polyethylene implants; three implants were containing test sealers and one was empty tube as negative control. The animals were sacrificed at third day and third month after implantation and the implants were dissected with 2cm of surrounding tissue margins. Then, tissue reactions to the test materials were evaluated histologically and quantitatively by a pathologist under light microscope, after histologic processing and staining with H-E. The obtained results were analyzed statistically by Mann-Whitney test.
Results
After 3 days, tissue reaction to ZOE was more acute than AH26, Roth 801, and control group. But after 3 months, no significant difference was observed among these three sealers and among those and control group.
Discussion
According to this study, all of the sealers cause inflammatory reactions immediately after contact with tissue, but the intensity of these responses decrease with time. The acute responses of third day changed to chronic, proliferative, healing processes in third month.Keywords: Endodontic Sealers, Tissue reaction (response), Subcutaneous Implantation}
نکته
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