جستجوی مقالات مرتبط با کلیدواژه « fenugreek » در نشریات گروه « پزشکی »

It is hypothesized that fenugreek seeds are a rich source of fiber with anti-diabetic effects, which can help to lower blood glucose in patients with polycystic ovary syndrome (PCOS). In this study, the clinical and metabolic effects of fenugreek were compared to those of metformin in women with PCOS aged 16-40 years.

In a randomized, triple-blind, parallel clinical trial, the efficacy of fenugreek 333 mg (n=55) was compared with metformin 500 mg (n=55), both administered three times a day in women with PCOS of reproductive age. Changes in some clinical outcomes and metabolic laboratory profile outcomes were evaluated at baseline and two months after the study.

By the end of the intervention period, all investigated factors improved significantly in patients of both groups (p<0.05). Reduction in biometric indices (body mass index and waist–hip ratio), fasting blood sugar (FBS), and insulin resistance was significantly higher after metformin consumption (p<0.001). Metformin also significantly improved irregular menstruation (p=0.02). In contrast, fenugreek significantly improved patients' lipid profiles, including low-density lipoprotein (LDL), high-density lipoprotein (HDL), and triglyceride (TG) compared to metformin (p<0.001). Both interventions improved the patient's hair loss and hirsutism.

Fenugreek cannot substitute metformin in PCOS treatment. However, regarding its lipid-lowering ability and low frequency of adverse effects, it can be used as an adjuvant treatment in PCOS, especially in PCOS patients with hyperlipidemia and severe hair loss.

Fenugreek has a long history as both a culinary and medicinal herb in the ancient world. In the current study, the authors aimed to determine the effect of this plant on diclofenac-induced hepatic, renal and duodenal damages.

Thirty five albino rats were randomly divided into five groups consisting of seven rats each. The extract of fenugreek seeds or Trigonella foenum-graecum (TFG) was administered to the rats in groups III and IV via the orogastric route. Diclofenac at 50mg/kg was also administered by the oral route to the rats in groups II, III, IV and V to induce hepatotoxicity and nephrotoxicity. 500mg/kg Levofloxacin was administered as treatment to rats in group V. Twenty four hours after the last treatment, all animals were sacrificed and the organs of interest removed and dissected for histopathological examinations.

The extract of TFG increased the weight of kidney and liver tissues relative to total body weight, maintained the histology of the kidneys at a concentration of 500 and 1000mg/kg, and ameliorated the damages observed in the intestinal mucosa following administration of diclofenac. The extract also mitigated hepatocytic damages, interhepatocytic hemorrhages, vascular congestions and restored the hepatocytes’ arrangements.

The findings of the current study demonstrate that the TFG extract produced promising therapeutic effects by significantly preventing toxicity in the duodenum, liver and kidneys of the rats by healing the diclofenac-induced damages.

Trigonella L. is a well-known worldwide growing genus of the Fabaceae family. In addition to food, the plants have various medicinal properties, including reducing fat and blood sugar, antibacterial, anti-ulcer, and analgesic.

Variability in agro-morphological traits, phenolic compounds, and proximate composition of the aerial parts of some Iranian Trigonella and its relative e.g. Medicago L. species was studied to introduce the superior species for further use in breeding and exploitation programs.

The seed samples of T. astroides, T. elliptica, T. filipes, T. foenum-graecum, T. spruneriana, M. crassipes (syn: T. crassipes), M. monantha (syn: T. monantha), M. monspeliaca (syn: T. monspeliaca), M. orthoceras (syn: T. orthoceras), and M. phrygia (syn: T. aurantiaca) were collected from different regions of Iran, and then were cultivated at the same agronomic conditions. Morphological traits were measured by a ruler, digital caliper and scales. Proximate composition (moisture, ash, fibre, protein, fat, and carbohydrates) and phenolic acids of the aerial parts were determined by the AOAC method and HPLC, respectively.

Significant morphological differences among the studied species were observed. The highest protein content was measured in M. orthoceras (13.4 ± 0.4 %), followed by T. filipes (11.5 ± 0.8 %), and T. spruneriana (11.1 ± 0.4 %). Fibre content was ranged from 0.7 ± 0.04 % to 4.9 ± 0.4 %. In the extracts of the studied species, catechin, chlorogenic acid, and p-coumaric acid were found in abundance (0.01 ± 0.05 - 69.32 ± 0.7 mg/g DW).

Trigonella filipes and T. spruneriana could be selected as suitable species for further exploitation in food and pharmaceutical industries.

The green synthesis of nanoparticles using plants presents important advantages over other biological systems. Natural compounds present in plant extracts can reduce metal ions to nanoparticles in a single-step green synthesis process. Seeds of fenugreek with various compounds and antioxidant activity are suitable for green synthesis.

In this study, the performance of fenugreek seeds extract was evaluated for iron nanoparticles production.

The fenugreek (Trigonella foenum-graecum L.) seeds were extracted with a distilled water solution at environmental temperature and this aqueous extract was used for the iron nanoparticles synthesis. Response surface methodology was applied to optimize nanoparticle production by considering three independent variables: the extract to metal ion ratio (1.5-6.5), incubation time (30-90 min), and temperature (35-65 °C).

Mixing the fenugreek seeds extract and iron salt solution with a volume ratio of 1.5 at 36.5 °C for 90 min led to the optimization of iron nanoparticle production with the narrowest size distribution. At the optimized condition, the nanoparticle size was in the range of 20-40 nm.

Iron nanoparticles were successfully synthesized with fenugreek seed extract. Physical parameters such as time, temperature, and mixing volume ratio of the extract to metal ions can control the average size of the synthesized green iron nanoparticles.

Anorexia and cachexia are one of the major problems in patients suffering from advanced malignancies.

This study aimed at evaluating the efficacy of herbal combination containing Fenugreek, Fennel, and Chicory supplementation to the high-dose megestrol for the treatment of cancer-induced cachexia and anorexia.

This quasi-experimental study was performed on 47 adult patients with advanced malignancy; they experienced anorexia and weight loss over the 2 past months and referred to a university-affiliated hospital (Omid) in Isfahan, Iran. Patients who had met the inclusion criteria were assigned to take either herbal combination or placebo tablets in addition to megestrol (160 mg daily) for a 2-month follow-up. All patients’ demographic information, weight changes, anthropometric indices, as well as the quality of life criteria were recorded at the baseline and after the duration of follow-up.

Patients in the herbal combination group experienced a mean weight gain of 1.5 kg, while patients in the placebo group had an average weight loss of 0.6 kg. Anthropometric indices including triceps skinfold thickness, mid-arm muscle circumference index, and grip strength were significantly improved in the herbal combination group. The other evaluated criteria such as quality of life, functional assessment of anorexia/cachexia therapy (FAACT), and some factors of Anderson criteria were significantly improved in the herbal combination group than the placebo group.

Given the ameliorated results of the herbal combination supplementation in terms of weight gain and appetite improvement, as well as physical and quality of life enhancement, it seems that the herbal combination can be used as an adjunctive treatment for the management of patients suffering from cancer-induced cachexia and anorexia.

Mathematical algorithms offer a useful method for quantitative analysis of compounds in multi-component mixtures to overcome the overlapping problems occurred in UV spectrophotometry. The aim of this study is to develop a method to determine the bioactive compounds in herbal dosage forms produced from fenugreek extract. A UV- spectrophotometric method based on mathematical algorithm was used to simultaneous determination of trigonelline (TRG), diosgenin (DI) and nicotinic acid (NA). The maximum absorbance (λmax) was determined to be 232.65 nm, 296.23 nm, and 262.60 nm for TRG, DI and NA respectively. The calibration curves showed good linearity for all analytes in the concentration range of 1–20 μg/mL (R2=0.9995, 0.9997, 0.9994 for TRG, DI and NA respectively). The Intra- and inter-day precisions were in the range of 1.1-10.7% and 1.2-8.2% respectively. The accuracy of the method was 96.0% for TRG, 92.9% for DI, and 104.2% for NA. The limits of detection (LOD) and quantification (LOQ) were found to be 0.91 and 3.06 µg/mL for TRG, 0.99 and 3.30 µg/mL for DI and 0.33 and 1.10 µg/mL for NA. The validated method was applied for determination of the analytes in tablet, capsule and biofilm dosage forms prepared by fenugreek seed extract. The mean recovery percentages of the analytes were in the range of 90.0-97.4%, 85.6-105.4%, and 90.0-99.0% for tablet, capsule, and film dosage forms respectively. Generally,the validated method could be a good candidate for routine spectrophotometry determination of the analytes without any necessity for pre-analysis extraction.

 Effective interventions on exclusive breastfeeding that are appropriate for the existing conditions can have significant benefits on maintenance, continuity, and promotion of breastfeeding in mothers. The aim of this study is to evaluate the effect of Fenugreek on breast milk sufficiency in nursing mothers.

In this review, trials on the effect of Fenugreek on breast milk sufficiency were searched on the electronic databases of Scopus, EMBASE, Cochrane, Web of Science, and Medline, with no language or time restrictions before the end of December 2019, using the combination related keywords of Mesh. Study selection was done by two reviews.

Reviews of 9 eligible clinical trials indicated the positive effect of fenugreek on breast milk adequacy and increased breast milk supply markers in the research participants compared to the control group. Effects of Fenugreek on breastfeeding adequacy were demonstrated in increasing neonatal weight gain, breastfeeding frequency, and fecal excretion frequency, number of changing diapers, increased breast milk production, and increased maternal prolactin hormone levels.

According to the results of reviewing previous studies, the use of fenugreek to improve breastfeeding adequacy and promote neonatal growth is recommended, considering its ease of access and use and rare adverse effects on the mother and infant.

Saponins identified from fenugreek (Trigonella foenum-graecum) seeds are reported effective on dyslipidemia. However, the definite mechanism is still not elucidated systematically. In this study, we evaluate the effects of saponin extract on cholesterol absorption, metabolism, synthesis, and reverse cholesterol transport in vivo.
Saponin extract was prepared according to a craft established in our previous study. After the establishment of dyslipidemia model, 40 male Sprague-Dawley rats were divided into five groups, namely the control group (normal diet plus normal saline), HFD group (high fat diet plus normal saline), Lipitor group (high fat diet plus Lipitor (2 mg/kg)), and L, M, and H-saponin groups (high fat diet plus saponin in dosages of 6, 12, and 24 mg/kg, respectively). Rats were sacrificed at the end of the 9th week after treatment. Biochemical characteristics of rats were tested, histopathological sections of liver tissue were observed, and the protein and mRNA expression of related factors of cholesterol in the intestine and liver were determined. One-way ANOVA test (SPSS software version 11.5, Chicago, IL, USA) was used to determine statistically significant differences between the HFD and other groups.
In saponin groups, the serum lipid, bile acid efflux, anti-peroxide activities, and lipid area of liver tissue improved. Cholesterol 7alpha-hydroxylase and scavenger receptor class B type I elevated in the liver. 3-hydroxy-3-methylglutaryl coenzyme A reductase levels were suppressed in both the serum and liver. However, significant cholesterol efflux was not found and Niemann-Pick C1-Like 1 levels elevated in the intestine.
The mechanisms of saponin in Fenugreek effect on ameliorating dyslipidemia are probably related to accelerated cholesterol metabolism, inhibited cholesterol synthesis, and facilitated reverse cholesterol transport, but not cholesterol absorption.

Several studies have been conducted to examine the effect of suture material on the skin during healing of the wound while a few articles reviewed the musculoskeletal response. In this study, the effects of the two plants, myrtle and fenugreek, on the primary inflammatory response of the tongue muscles to the types of suture in diabetic rats are examined.
For conducting this study, 96 Wistar healthy male white rats weighing between 250 and 300 g were selected. The animals were divided into 3 groups, 32 each, consisting of the diabetic group, the diabetic-myrtle group, and the diabetic-fenugreek group. All the animals became diabetic two weeks before the study using Streptozotocin (STZ). For carrying out the task, all animals were anesthetized on the first day using ketamine with a dosage of 60 mg/kg and xylazine (Rampon) with a dosage of 5.7 mg/kg. Four wounds were made using No. 15 blade, and each wound was sutured using one sample of suture string (simple interrupted suture). Then, in the myrtle and fenugreek groups, these materials were placed on the sutures using swabs. After this, from each group, 8 animals were sacrificed using ether. On days 2, 4, 7 and 14, samples were taken from the suture sites with intact margins and were sent to the pathological lab, and the degree of inflammation was examined using a light microscope with magnifications of 40 and 100. At last, the data were analyzed using Wilcoxon, post hoc ( by SPSS version 13.5).
This study showed that the least amount of inflammation on all days was associated with silk string followed by plain catgut in the diabetic group, and there was a significant relationship (P=0.001) in that regard with the two other suture strings used; chromic catgut and monofilament polyamide. In the myrtle group, chromic catgut and monofilament polyamide inflammation were not significantly different as compared with the other two suture strings in the control group on all days of the study. The findings showed that in the fenugreek group and the control silk and monofilament polyamide, the inflammation severity was not significantly different from the two suture strings in the control group on all days of the study.
The findings of this study showed that the two plants myrtle and fenugreek reduce the inflammatory response in plain catgut though the effect of myrtle was more significant. Myrtle is also effective in reducing inflammation in silk while fenugreek is effective in reducing the inflammation caused by chromic catgut.

Fenugreek (Trigonella foenum-graecum) is a medicinal plant with potential applications in the medicinal purposes. Fenugreek has been used in food as a flavouring agent since ancient times in many countries like Greece, Rome and Egypt. It has a special place in the traditional medical system. The aim of this study was to review phytochemistry and pharmacological effects of Trigonella foenum-graecum.
This research was a review study. Data were collected using articles in various databases and books about pharmacological effects of Trigonella foenum-graecum.
The seeds are rich sources of lipids, protein, mucilage, calcium, dietary fiber B vitamins, Iron, protease inhibitors and several steroid saponins, tiny amounts of alkaloid, furostanol glycosides and steroidal peptide. As a medicinal plant, fenugreek recognized as a galactagogue or lactation stimulant in women after child birth as well as for its ability to treat wounds and sore muscles. In addition, it has the ability to be as antibacterial, anti-ulcer, anti-cancer, anthelmintic (antagonistic effect against parasitic worms), and antinociceptive (pain-reducing) properties. In recent years, laboratory studies and clinical trials have focused on the potential activity of fenugreek as a natural medicine.
These studies have shown that fenugreek plants possess immunomodulatory, hypocholesterolaemic, hypoglycaemic, gastro- and hepatoprotective and antioxidative properties. Pharmacological properties of fenugreek have been explored to identify a role for the plant in diabetes management and in cardiovascular health, indicating the presence of bioactive compounds in fenugreek, which may be responsible for its health benefits.

Fenugreek (Trigonella foenum graecum), native to southern Europe and Asia, is an annual herb with white flowers and hard, yellowish brown and angular seeds, known from ancient times, for nutritional value beside of its medicinal effects. Fenugreek seeds are rich source of gum, fiber, alkaloids, flavonoids, saponins and volatile content. Due to its high content of fiber, fenugreek could be used as food stabilizer, adhesive and emulsifying agent to change food texture for some special purposes. Some evidence suggests that fenugreek may also be regarded as antidiabetic, anticarcinogenic, antioxidant, antibacterial agent, antianorexia agent, and gastric stimulant, as well as remedy for hypocholesterolemia and hypoglycemia. The present article is aimed to review the potential applications of fenugreek as a functional food and nutraceutical agent.