جستجوی مقالات مرتبط با کلیدواژه "ferula" در نشریات گروه "پزشکی"

Medicinal plants have effectively treated Alzheimer’s disease (AD). In this study, the oleo-gum-resin of Ferula persica known as sagapenum was selected to investigate its inhibitory activity toward enzymes involved in the creation and progression of AD. Also, the phytochemical analysis, which was not previously reported in the literature, was conducted. The in vitro inhibitory activity of dichloromethane, methanol, and aqueous extracts was investigated toward acetylcholinesterase (AChE) and butyrylcholinesterase (BuChE) according to the modified Ellman’s method. Moreover, the phytochemical analysis of the most potent extract was conducted using different column chromatography techniques. The dichloromethane extract showed selective BuChE inhibitory activity (IC50 = 23.41 µg/mL), compared with donepezil as the reference drug (IC50 = 1.97 µg/mL). Phytochemical analysis of the related extract led to the isolation and identification of aurapten, farnesiferol A, umbelliprenin, farnesiferol C, farnesiferone A, karatavicinol, ferocaulidin, and ligupersin A, which were assayed toward cholinesterases (ChEs). Farnesiferol A was the most potent and selective inhibitor of BuChE (IC50 = 31.46 µg/mL). Moreover, it showed good β-secretase 1 (BACE1) inhibitory activity (IC50 = 5.14 µM), compared with the positive control, OM99-2 (IC50 = 0.014 µM) to be considered a multi-target directed ligand against AD. Selective anti-BuChE activity of the dichloromethane extract of sagapenum, as well as farnesiferol A and its good anti-BACE1 activity, may play a significant role in the development of anti-AD supplements.

Candidiasis therapy is a complicated concern because of the occurrence of resistance to antifungal agents. We studied the anti-fungal effects of Ferula macrecolea essential oil (FME) against Candida albicans resistant and sensitive strains, as well as its cytotoxic effects against normal and cancer cell lines.

The minimum inhibitory concentration (MIC) and minimum fungicidal concentration (MFC) of F. macrecolea essential oil against C. albicans ATCC 5027 and C. albicans ATCC 76616 were studied by broth-microdilution approach. The cytotoxicities of FME on HGF1-PI (normal gingival cell line) and HepG2 (liver cancer cell line) cells were also studied.

The main components of essential oil were terpinolene (71.25%), n-nonanal (6.32%), and linalool (3.95%), respectively. The MIC and MFC of FME on C. albicans sensitive to nystatin were 1.6 and 2.0 μg/mL, respectively. The MIC and MFC of FME on nystatin-resistant strains were 3.3 and 4 μg/mL, respectively. The MIC and MFC of terpinolene on C. albicans sensitive to nystatin were 0.8 and 1.0 μg/mL, respectively. The MIC and MFC of terpinolene on nystatin-resistant strains were 2 and 2.4 μg/mL, respectively. The essential oil and terpinolene had no significant cytotoxic effects against normal cells.

We revealed the promising antifungal effect of F. macrecolea essential oil and its main component, terpinolene, against C. albicans sensitive and resistant to nystatin with no significant toxicity on normal cells.

There are few evaluation about the effects of Fennel and Ferula on human polycystic ovary syndrome (PCOS). The goals of this study were to evaluate and compare the effectiveness of two medicinal plants of the Apiaceae family (Fennel and Ferula) in management of PCOS. The sample size was 47 participants with PCOS who were randomly divided into 3 groups. The Ferula assa-foetida L group received 100 mg of Ferula (n=14), the Foeniculum vulgare group received 46 mg of Fennel (n=15), and the placebo group received placebo twice daily for 3 months (n=14). Before the intervention, there were no significant differences between groups in terms of clinical parameters, endometrial thickness, or ovarian volume. After the interventions, the number of ovarian follicles was decreased in the Ferula and Fennel groups as compared to the placebo group (p<0.05). The number of ovarian follicles in both ovaries in the Ferula and Fennel group decreased and this decrease was significant in the right side as compared to placebo group. Our findings showed significant changes in dehydroepiandrosterone sulfate (DEHAS) and thyroid-stimulating hormone (TSH) levels after the intervention (p<0.03) between the Ferula and Placebo groups. Since use of Ferula could make significant changes in TSH and DEHAS levels and decrease the number of right and left ovarian follicles compared to Fennel and placebo, it can be concluded that this herbal medicine is more effective than Fennel in managing PCOS.

Ferula is a genus of the family Apiaceae and it includes around 170 species of flowering plants mostly native to the Mediterranean region and eastern to central Asia. In Iran, Ferula spp. are widely used in cuisine and traditional medicine. This review discusses the anti-inflammatory, anti-oxidant, and immunomodulatory activities of different species of Ferula. 

To prepare the present review, Scopus, Google Scholar, PubMed, and Web of Science scientific databases were searched to retrieve relevant articles published from 1985 until December 2020. 

Based on our literature review, Ferula plants and their derivatives decrease the levels of inflammatory mediators and exert anti-apoptotic effects. Under oxidative stress conditions, these plants and their constituents were shown to decrease oxidative markers such as malondialdehyde, reactive oxygen species, and nitric oxide but increase superoxide dismutase, glutathione peroxidase, catalase activity, and glutathione level. Ferula plants and their constituents also showed immunomodulatory effects by affecting various cytokines. Besides, in vivo and in vitro studies showed hypotensive, neuroprotective, memory-enhancing, anti-oxidant, hepatoprotective, antimicrobial, anticarcinogenic, anticytotoxic, antiobesity, and anthelmintic effects for various species of Ferula and their constituents. These plants also showed a healing effect on gynecological issues such as miscarriage, unusual pain, difficult menstruation, and leukorrhea.  All these beneficial effects could have resulted from the anti-inflammatory, anti-oxidant, and immunomodulatory effects of these plants and their constituents.

Based on the available literature, members of the genus Ferula can be regarded as potential therapeutics against inflammatory conditions, oxidative stress, and immune dysregulation.

More than 90% of oral cancers are cases of squamous cell carcinoma. Standard treatment of cancer includes a combination of surgery, chemotherapy and radiotherapy. Each of these treatments, however, brings about certain problems and side effects. Today herbal medicine, has become a more preferable option in dealing with health problems or preventing them because this type of medicine has better compatibility with the body and does not cause undesirable side effects. In this study , the effect of Ferula persica plant methanol extraction on Cox-2 levels in SCC induced rat tongue is conducted in vivo.
In this lab research, 75 rats from SD race in the age – range of 2/5 – 3 months were selected and put in five groups. In order to induce tongue carcinoma, 4– Nitroquinoline 1 (4 NQO) powder was used 3 times a week for each rat. Furthermore, Ferula persica extract was given to each of the groups in order to examine Cox-2 changes in the blood.
Comparison of Cox-2 average in various groups resulted in the observation that there was significant difference between the Cox-2 levels in the groups which had only received carcinogen and the other groups. In this group, Cox-2 level was less and in the group that had received Ferula extract (500 mg) along with carcinogen , Cox-2 level was found to be more than other groups.
Ferula persica extract does not have reducing effect on serum Cox-2.

The genus Ferula L. includes perennial flowering plants belonging to the Apiaceae family. This genus is a rich source of biologically active phytochemicals such as sulfur-containing derivatives, coumarins, sesquiterpenes, sesquiterpene lactones, sesquiterpene coumarins, glucuronic acid, galactose, arabinose, rhamnose, and daucane esters. Over the last decade, considerable attention has been paid to biological activities of these compounds; it is assumed that the most prominent biological features of the genus Ferula are their cytotoxic effects. This article discusses cytotoxic activity of the genus Ferula and their important compounds.
In this mini-review article, papers published from 1990 to April 2016 were included and the following information was discussed; cytotoxic activity of the genus Ferula and their important compounds, the type of cell line used in vitro, concentrations of the extracts/active compound that were used, and the underlying mechanisms of action through which Ferula-related chemicals induced cytotoxicity. In addition, we explained different mechanisms of action through which the active constituents isolated from Ferula, could decrease cellular growth.
It is highly recommended that potent and effective compounds that were isolated from Ferula plants and found to be appropriate as adjuvant therapy for certain diseases, should be identified. Also, the versatile biological activities of sesquiterpene coumarins suggest them as promising agents with a broad range of biological applications to be used in the future

Different irrigating solutions with high antimicrobial activity have been introduced for cleaning of the root canal system. However, effects of Prangos ferulacea (PF), Ziziphora tenuior (ZT), Dracocephalum moldavica (DM), and Ferula gummosa (FG) on oral and dental pathogens have not been extensively evaluated due to their optimal biocompatibility and insignificant side effects. The aim of this study was to evaluate the antibacterial effects of essential oils of mentioned plants on Enterococcus faecalis.
In this in vitro study the plants were collected from Zanjan Province, Iran. Analysis of the essential oil was carried out by gas chromatography/mass chromatography. Micro‑broth dilution and disc diffusion methods were used for assessment of the antimicrobial activity, and minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) were evaluated.
All the four essential oils had antibacterial effects on E. faecalis, and ZT had the greatest antibacterial activity. Assessment of the mean diameter of the growth inhibition zone showed higher antibacterial activity of PF and ZT than that of chlorhexidine. The MIC and MBC of ZT showed that the antimicrobial activity of ZT against E. faecalis was greater than that of other plants evaluated in this study.
The results of this study indicated significant antibacterial effects of the mentioned plants on E. faecalis. The greatest antimicrobial activity belonged to ZT. The current study suggests extraction of effective compounds in these medicinal plants to use them in the clinical setting.

Different irrigating solutions with high antimicrobial activity have been introduced for cleaning of the root canal system. However, effects of Prangos ferulacea (PF), Ziziphora tenuior (ZT), Dracocephalum moldavica (DM), and Ferula gummosa (FG) on oral and dental pathogens have not been extensively evaluated due to their optimal biocompatibility and insignificant side effects. The aim of this study was to evaluate the antibacterial effects of essential oils of mentioned plants on Enterococcus faecalis.
In this in vitro study the plants were collected from Zanjan Province, Iran. Analysis of the essential oil was carried out by gas chromatography/mass chromatography. Micro‑broth dilution and disc diffusion methods were used for assessment of the antimicrobial activity, and minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) were evaluated.
All the four essential oils had antibacterial effects on E. faecalis, and ZT had the greatest antibacterial activity. Assessment of the mean diameter of the growth inhibition zone showed higher antibacterial activity of PF and ZT than that of chlorhexidine. The MIC and MBC of ZT showed that the antimicrobial activity of ZT against E. faecalis was greater than that of other plants evaluated in this study.
The results of this study indicated significant antibacterial effects of the mentioned plants on E. faecalis. The greatest antimicrobial activity belonged to ZT. The current study suggests extraction of effective compounds in these medicinal plants to use them in the clinical setting.

Cancer is one of the most significant causes of death around the world, and oral squamous cell carcinoma (OSCC) represents 90% of oral malignancies. Ferula persica has been used for treatment of different diseases in Iranian traditional medicine. Previous studies reveal some evidence relating to the value of preventing malignancies through F. persica..
The aim of the present study was to evaluate the protective effect of methanolic extract of Ferula persica in rat tongue neoplasm induced by 4-Nitroquinoline-1-Oxide (4-NQO)..
This experimental study was carried out in the pharmaceutical research center in Tabriz, Iran. According to ethical considerations, the results of the pilot study (five rats in each group) and pathologic changes in 30% of cases with considering α = 5%, P = 80%, and d = 5%, 15 samples for each group were determined. In this study, the OSCC was induced by 4-NQO in 60 SD rats (in four groups). At the same time, three groups of rats received Ferula persica methanolic extract (FPME) intraperitoneally (IP) in the doses 50, 250, and 500 mg per kilogram of body weight twice each week for 14 weeks..
The obtained weight differences between groups were not significant (P = 0.18). Pathological changes in the treated and non-treated groups were significantly different (P The results showed that the FPME prevented the progress of the malignancy in the OSCC model in rats. However, further investigations are necessary to clarify effective fractions, mode of action of the FPME, and its potential therapeutic application in different types of cancer..

Ferula gummosa Boiss. (Apiaceae family), which has been used in traditional medicine of Iran as anti vaginal infection, anti-sinusitis, sedative, and anti-inflammation. In this research, the gums of plant root were collected from the Heidary nature reserve in Razavi Khorasan Province (Iran) in August 2012. The ethnopharmacological data about traditional uses of plant were obtained from the rural healers (women 67-75 year) of this region. Essential oil of the plant root gum was obtained by hydrodistillation (Clevenger apparatus) and was analyzed by gas chromatography–mass spectrometry. Antibacterial activity of plant ethanolic extract was studied in vitro against Candida albicans and 9 Gram-positive and negative bacteria using well method and the minimum inhibitory concentration (MIC) assay. Results showed that a total of 39 components have been identified in the plant sampl oil, representing 81% of the total oil and β-pinene (19.88%), guaiol (8%), shyobunone (6.96%), delta-cadinene (4.65%), α-pinene (3.16 %), β-phellandrene (3.28%) and myrtenol (2.8%), were the main essential oil composition, respectively. The results from antibacterial screening (Table 2), were showed that C. albicans (25.2 ± 1.6), Staphylococcus epidermidis (23.6 ± 0.7 mm), Staphylococcus aureus (21.3 ± 0.2 mm), Escherichia coli (16.5 ± 0.8 mm), Bacillus cereus (19.5 ± 0.1 mm), Enterococcus faecalis (17.2 ± 0.8 mm) and Pseudomonas aeroginosa (17.8 ± 0.2 mm) inhibition zone and MIC (35.4-112 μg/ml) were the most sensitive pathogenes to the plant extract respectively, which followed Shigella (12.3 ± 0.3 mm) and Klebsiella pneumonia (12.5 ± 0.2 mm) were found to be moderate sensitive bacteria and then the Salmonella typhymorium which completely was resistant to plant root extract. According to these results, it can be concluded that the extract of F. gummosa L. have suitable antimicrobial and anti-Candidacies activity, which can be used as natural anti-infection to treat of many infection diseases, especially in vaginal infection.

From the ancient times, medicinal herbs have been regarded as efficient resources for the treatment of diseases. Among the diseases that can be treated by medicinal herbs, infectious diseases like oral ones are of notable importance.. The aim of this study was to evaluate the antibacterial effects of Ferula assa-foetida L (F. assa-foetida L.) and Quercus infectoria Olivier (Q. infectoria Olivier) aqueous and ethanolic extracts on Streptococcus mutans (S. mutans) and Streptococcus sanguis (S. sanguis).. The studied plants were F. assa-foetida L. and Q infectoria Olivier. Their extracts with different concentrations of 100, 50, 25, 12.5, 6.25, and 3.125 mg/mL were prepared in culture medium, with well diffusion method, and, for control, their antibacterial effects were compared with chlorhexidine. For each extract, the antibacterial ability was determined based on the created inhibition zone diameter in the microbial culture medium.. The aqueous and ethanolic extract of F. assa-foetida L. lacked the inhibitory effect against the growth of S. mutans and S. sanguis bacteria. There was a significant difference among the inhibitory zones created by dissimilar concentrations of Q. infectoria (P = 0.025). Also, the aqueous and ethanolic extracts’ minimum inhibitory concentration (MIC) for S. mutans bacterium was calculated to be 12.5 mg/mL, while its value for S. sanguis bacterium was 6.25 mg/mL.. The results of our study, regarding the observed effects based on differences in concentrations, suggest that further and more comprehensive studies should be undertaken to determine the appropriate concentration for obtaining the effect of the extract of F. assa-foetida L. and Q infectoria Olivier on S. mutans and S. sanguis..