جستجوی مقالات مرتبط با کلیدواژه « fetuin a » در نشریات گروه « پزشکی »

Hepatokines secreted by the liver play a pivotal role in the pathogenesis of type 2 diabetes, directly influencing glucose and lipid metabolism. Exercise training is recognized as an effective treatment strategy for type 2 diabetes. This study aims to investigate the impact of moderate intensity continuous training (MICT) on the levels of Fetuin-A and tumor necrosis factor-alpha (TNF-α) in type 2 diabetic rats.

Fifteen male Wistar rats aged between 8 and 10 weeks were randomly assigned to three groups (5 rats in each group): healthy control, diabetic, and training diabetic. Diabetes was induced through intraperitoneal injection of nicotinamide and streptozotocin (STZ). The MICT protocol involved eight weeks of continuous running, five days per week, at 55-60% of maximal oxygen consumption. Blood samples were collected 48 hours after the last training session, and serum levels of TNF-α and Fetuin-A were measured.

The observed reductions in Fetuin-A, TNF-α, and glucose levels were not statistically significant in the trained group compared to the diabetic group. However, a significant decrease in insulin levels (p=0.002) and insulin resistance (p=0.01) was observed in the trained group compared to the diabetic group.

In conclusion, moderate intensity continuous training, as a non-pharmacological intervention, appears to play an effective role in the management of type 2 diabetes by improving insulin resistance and reducing insulin levels.

Fetuin-A is a glycoprotein that is synthesized by liver cells. Studies have shown that this hepatokine is linked to various metabolic disturbances such as obesity, and diabetes. Therefore, this study was designed to evaluate the role of fetuin-A in the pathogenesis of metabolic disturbances.

The present study was a review article. The terms of “fetuin-A”, “diabetes”, “obesity”, “chronic kidney disease (CKD)”, “cardiovascular disease (CVD)”, “non-alcoholic fatty liver disease (NAFLD)”, “cancer”, “bone metabolic diseases” and “metabolic disease” were used for searching of research papers in databases including Embase, Scopus, Web of Science, PubMed and Google Scholar. The literature search was limited to papers published up to November 2019.

Fetuin-A could be involved in the pathogenesis of metabolic diseases such as obesity, diabetes, CKD, CVD, cancer, bone metabolic diseases, and NAFLD through various signaling pathways.

The results of the current study showed that fetuin-A could be involved in the pathogenesis of the metabolic disease. However, the study on these findings needs further research and a better understanding of these pathomechanism communications, which can be promising and helpful in preventing and better targeting metabolic disorders.

This study aimed to investigate the possible effects of fetuin-A on an adenine-induced chronic kidney disease (CKD) model in male rats. 

Rats were divided into three groups: group A included rats fed a normal diet; group B included rats fed a normal diet with 220 mg/kg adenine daily for 21 days; group C included rats fed a normal diet with 220 mg/kg adenine daily for 21 days and intraperitoneally administered with 5 mg\kg fetuin-A every other day for 2 weeks. Serum samples were assayed for serum creatinine, urea, sodium, potassium, calcium, phosphorus, tumor necrosis factor (TNF), interleukin-6 (IL-6), and estimated glomerular filtration rate (eGFR), and immunohistochemical staining was performed.

Group B showed a significant increase in serum creatinine, urea, phosphorus, potassium, TNF, and IL-6 and a significant decrease in serum sodium, calcium, and eGFR compared with group A. Regarding immunohistochemistry, group B showed increased apoptosis. In group C, fetuin-A reduced the urea, creatinine, and phosphorus levels, and in group C, fetuin-A decreased inflammation and apoptosis by reduction of caspase-3 staining.

Fetuin-A improved kidney function in CKD due to its anti-inflammatory and anti-fibrotic role.

Crimean-Congo Hemorrhagic Fever (CCHF) is a disease with high morbidity and mortality, which is an important health problem in the world. Therefore, we aimed to evaluate the effects of plasma fetuin-A (FA) level, which is a new parameter in terms of prognosis and mortality of CCHF.

A total of 87 patients were included who presented to the Emergency Department, Bağcılar Training and Research Hospital, İstanbul, Turkey with the diagnosis of CCHF from Feb 1, 2019 to Feb 1, 2020. The patients were divided into three groups as tick bite, contact history, and endemic area travel according to the transmission type, and two groups according to the presence of mortality or not. The laboratory data of the patients were compared within these groups. Relationship of hemogram, C-reactive protein (CRP), D-Dimer, sedimentation, lactate, and FA levels between groups were evaluated.

The average age of the patients was 62.52±14.94 years and 27(31%) of them were women. Mortality rates were in 6(6.9%) patients from endemic areas (P=0.015). While the FA level of the mortality group was 171.6±30.0 mg/L, it was 230.3±25.0 mg/L in the survivors (P=0.001). There was a moderate and strong negative correlation of FA level with mortality, tick history, and hospitalization. In ROC curve analysis of mortality and FA levels, parameters were determined as sensitivity 97.4% and specificity 96.2%.

In addition to FA levels, as anticipated by our hypothesis, lactate, CRP, and sedimentation values can be used to predict prognosis and mortality in cases of CCHF.

Multiple sclerosis (MS) is a chronic inflammatory disease affecting sensory and motor function in the central nervous system. Physical activities in the prevention and treatment of such conditions have shown promising results. However, their mechanisms of action have not been fully known yet and need further study. The present study aimed to evaluate the preventive effect of swimming exercise on some liver factors involved in inflammation and MS.  In this study, experimental autoimmune encephalomyelitis was induced in C57BL/6 mice, and the effect of a 6-week swimming exercise on the levels of fetuin-A, AMP-activated protein kinase (AMPK), and Nicotinamide adenine dinucleotide (NAD+) in their liver tissue was investigated by western blot analysis and NAD+ colorimetric assay. The study showed that EAE induction substantially (3.5 - fold) enhanced the fetuin-A levels and caused a reduction in AMPK and NAD+ amount. This is when doing 6 weeks of swimming exercise reduced fetuin-A to slightly above control. Also, levels of AMPK and NAD+ markedly increased in C57BL/6 mice with EAE. Doing regular exercise may limit the body’s inflammatory responses and reduce the severity of MS by regulating the expression of fetuin-A and increasing AMPK and NAD⁺ levels in liver tissue.

Prostate cancer is the most commonly diagnosed type of cancer and one of the leading causes of can-cer-related death in men. Numerous efforts have been made to improve existing diagnostic methods and develop a new biomarker to identify patients with prostate cancer. In line with current literature, we preferred new se-rum-based biochemical markers as Pentraxin-3, Fetuin-A and Sirtuin-7 in the present study.

A total of 174 patients aged 42-76 years were included in the study. Patients with pros-tate cancer (n = 38) were enrolled as Group 1 and patients with benign prostatic hyperplasia (n = 136) as Group 2. The serum levels of Pentraxin-3, Fetuin-A and Sirtuin-7 levels were compared between the groups.

The mean age of the patients was 61.9 ± 7.6 years (p = .001). The mean serum Prostate Specific Antigen levels 32.0 ± 59.6 (2.6-336) ng/mL and 10.0 ± 11.3 (2.5-77.4) ng/mL in Group 1 and 2, respectively (p = .029). The mean serum levels of Pentraxin-3 and Fetuin-Ain Group 1 were statistically significantlydifferent from Group 2(3.3 ± 4.4 ng/mL vs 1.8 ± 2.4 ng/mL, p = .002 and 466.8 ± 11.0 μg/mL vs 513.3 ± 11.0 μg/mL, p = .041,respec-tively). There was no significant difference between Group 1 and 2 according to serum levels of Sirtuin-7 (12.7 ± 8.2 ng/mL vs 12.7 ± 12.4 ng/mL respectively, p = .145).

Pentraxin-3, Fetuin-A and Sirtuin-7 may be effective in the diagnosis of prostate cancer in light of the current literature. In this study, it was found that Pentraxin-3 and Fetuin-A were significantly different in the diag-nosis of prostate cancer. Larger-scale prospective studies are needed to determine the importance of Pentraxin-3 and Fetuin-A in the diagnosis of prostate cancer.

Decreased physical activity is one of the main causes of the obesity epidemic. In the process of obesity, the secretion of some hepato-adipokines increases and causes metabolic disorders. Exercise plays an important role in improving the complications of obesity by regulating the levels of selected hepato-adipokine. The purpose of this study was to examine the effects of three types of resistance training methods on selected hepato-adipokine and lipid profiles in men with obesity.

The sample of the study included 44 sedentary men with obesity divided into 4 groups of traditional resistance training (TRT), circuit resistance training (CRT), and interval resistance training (IRT) as well as one control group. Fetuin-A, Fetuin-B, high-density lipoproteins (HDL), low-density lipoproteins (LDL), total cholesterol (TC), and triglyceride (TG) were measured using the ELISA method.

The results of the mixed model ANOVA analysis showed a significant interaction between the type of training used and time at the levels of Fetuin-A (F (1, 40) = 94273.16, P = 0.001, ES = 1.00) and Fetuin-B (F (1, 40) = 49697.67, P = 0.001, ES = 0.99. In addition, within-group comparisons showed that lipid profile improved in TRT and CRT groups compared to the pretest (P = 0.001), while in the IRT group this improvement was not significant (P > 0.05).

The result of the present study shows that three models of resistance training reduced the select hepato-adipokines level in comparison to the control group. However, IRT and CRT had the greatest effect on reducing Fetuin-A and Fetuin-B, respectively.

Beverages containing caffeine have an anti-obesity function. Reduction of visceral adipose tissue (VAT) inflammation is considered an important strategy to ameliorate obesity compilations such as insulin resistance. This study aimed to investigate the effect of 8-week caffeine supplementation on the messenger RNA (mRNA) expression of fetuin-A (FetA) in the liver and nuclear factor kappa B (Nf-κb) and toll-like receptor 4 (Tlr4) in the VAT of rats with a high-fat diet (HFD).

A total of 40 male Wistar rats were randomly divided into control, caffeine, HFD, and HFD+caffeine supplement groups. After 2 weeks of acclimatization, the rats were randomly fed with HFD (46% fat) and a normal diet (5% fat) for 8 weeks. The rats in the caffeine groups were gavaged with 6 mg of the caffeine solution per kg of body weight. FetA mRNA of the liver, Nf-κb, and Tlr4 mRNA of VAT were determined using real-time polymerase chain reaction (PCR).

The results indicated that FetA mRNA expression and weight gain in HFD+caffeine were significantly reduced compared to the other groups. Nf-κb mRNA expression was significantly higher in the HFD group than in the caffeine groups. No statistically significant differences were found in Tlr4 mRNA expression between the groups.

These findings suggest that consuming caffeine can prevent HFD-induced liver and adipose tissue (AT) inflammation.

Introduction:

 Atherosclerosis is associated with increased intima- media thickness (IMT) and vascular calcification (VC) in maintenance hemodialysis (MHD) patients. Fetuin-A is a serum protein, which inhibits vascular calcification. The aim of this study was to investigate the association between fetuin-A and VC, in a group of MHD patients. 

Methods:

 One hundred and forty-three MHD patients were included and followed for 3 years. Blood samples were studied for calcification and inflammation markers and fetuin-A was checked 3 times at the start, middle and the end of the study. We used common carotid doppler sonography for assessment of indices of VC, which were performed at baseline and at the end of the study. Vascular calcification was defined as a common carotid intima media thickness ≥ 0.8 mm on either side or the existence of any plaque or stenosis ≥ 50% on either side.

Results:

 From 143 patients (mean age 57.5 ± 15.9, 60.1% male), 104 patients (75.4%) had VC at baseline. The mean age and the prevalence of DM were significantly higher in patients with VC (P < .001 for both). There was no significant difference in the levels of Pi, PTH, and fetuin-A between the two groups. In a multiple logistic regression model at baseline only age (OR = 1.09, P < .001), and diabetes mellitus (OR = 4.59, P < .05) were associated with VC and dialysis vintage had a marginal association (OR = 1.20, P = .09). At the end of the study only age (OR = 1.12, P < .001), and CRP (OR = 1.14, P < .05) were associated with VC. The mean survival of patients with VC was significantly lower than the patients without VC (31.87 ± 0.95 vs. 33.73 ± 1.29, P < .05), however the mortality was not affected by fetuin-A level.

Conclusion:

 Survival rate of patients without VC was higher than the patients with VC. We didn’t find any correlation between the level of fetuin-A and VC. It seems that the traditional risk factors of VC, including age and diabetes mellitus are the main predictors of VC in MHD patients.

Fibroblast growth factor 21 (FGF21) and fetuin A are thought to be involved in the pathogenesis of metabolic disorders, such as type 2 diabetes. On the other hand, regular physical activity has an important role in the prevention and management of type 2 diabetes. The purpose of this study was to investigate effect of moderate aerobic exercise on serum levels of FGF21 and fetuin A in women with type 2 diabetes.

This was a semi-experimental study with a pretest-posttest design. The study was performed on 28 women with type 2 diabetes aged 40-50 years (mean weight: 70.58 ± 2.11) who were randomly divided into an exercise group (n=14) and a control group (n=14). The training intervention consisted of eight weeks of moderate aerobic exercise at 60-70% of maximum heart rate, five times a week. Serum levels of FGF21, fetuin A and some metabolic parameters were evaluated before the first session and 48 hours after the last session. All statistical analyses were performed in SPSS (version 24) using repeated measures ANOVA and at significance of 0.05. 

The eight-week aerobic training intervention caused a significant increase in FGF21 and insulin sensitivity as well as a significant decrease in fetuin A, fasting blood sugar and HbA1c (P=0.001).

As a complementary therapy, regular aerobic exercise can be beneficial for type 2 diabetes patients in improving some metabolic parameters as well as FGF21 and fetuin A levels.

Clinical partial remission (CPR) in most patients with type 1 diabetes (T1D) is observed shortly after clinical diagnosis. Increasing body weight and impaired insulin sensitivity may play a role in the pathogenesis of CPR. Several cytokines can also participate in the development of insulin resistance. To evaluate the relationship between birth weight, body mass index, and the concentrations of IL-8 and Fetuin-A, and the presence of clinical partial remission in children at the T1D onset.  The study group consisted of 134 children with a newly diagnosed T1D in whom the presence of CPR was evaluated in a further 2-year course of diabetes. The control group included 47 children withoutglucose tolerance disorders. The concentrations of IL-8 and Fetuin-A were determined by the ELISA method. CPR occurred in 75.34% of T1D patients. At T1D onset, higher values of BMI SDS in the remitters as compared to the patients without remission were observed. At the T1D onset, the concentrations of Fetuin-A (p=0.031) and IL-8 (p=0.042) were significantly higher in patients compared to those without CPR. Evaluation of Fetuin-A and IL-8 levels in patients with a newly diagnosed T1D can differentiate between patients with or without CPR.