جستجوی مقالات مرتبط با کلیدواژه "filler" در نشریات گروه "پزشکی"

Cosmetic dermatology has seen significant advancements in developing new materials and techniques to enhance skin beauty and combat signs of aging. One notable development is creating and analyzing fillers made by combining hyaluronic acid and polycaprolactone. This innovative filler type has gained popularity due to its unique properties, exceptional skin rejuvenation capabilities, and effectiveness in facial contouring. This study gathered information on dermal fillers and the effects of using hyaluronic acid and polycaprolactone by referencing papers from various databases such as Civilica, PubMed, Google Scholar, Science Direct, and SID. The authors conducted a study to explore the benefits and drawbacks of utilizing hyaluronic acid and polycaprolactone and their impact on filler durability and injectability. Research conducted by experts and studies on cosmetic fillers has highlighted the positive effects of hyaluronic acid and polycaprolactone, two powerful substances widely discussed in the beauty industry. Further research could improve the understanding and utilization of hyaluronic acid/polycaprolactone fillers, enhancing skin cosmetic treatments and increasing patient satisfaction.

Recently, many Iranian companies have started manufacturing hyaluronic acid based dermal fillers. Current review aimed to assess and compare the clinical safety and efficacy of 5 Iranian hyaluronic acid based dermal fillers.

The first part of the study reported, the overall safety and efficacy of 5 Iranian hyaluronic acid based dermal fillers for improvement of nasolabial folds in 150 participants (age 44.30±9.97 years) using clinical and objectives assessment methods. In the second part, we performed a comparative study among 5 tested dermal fillers.

Generally, at weeks 2, 12, and 24, 80.6%, 63.3%, and 60.66% of the participants, showed one grade or more improvement in the severity of nasolabial folds respectively. In all visits, the nasolabial folds biophysical parameters as well as the echo density dermis improved significantly compared to baseline. In comparative study, two fillers with the hyaluronic acid concentration of 24 mg/ml, showed the best objective efficacy, while in clinical evaluations, the filler containing mannitol has the best performance in reducing the severity of nasolabial folds showed.

Iranian hyaluronic acid based dermal fillers showed different levels of safety and efficacy for improvement of moderate to severe nasolabial folds, with efficacy.

The rheologic, mechanical, and pharmacological characteristics of hyaluronic acid (HA) gels vary in terms of their specific crosslinking technologies.

To evaluate the various characteristics of selected HA gels available in Iran, using simple, inexpensive, and reproducible experimental tests are necessary to better understand their appropriateness for specific indications.

The HA gels produced by various crosslinking technologies were evaluated by three experiments, including cohesivity, resistance to stretch, and microscopic examination. The gels subjected to these experiments in this study included Neuramis, Desirial, Belotero, Restylane, and Juvéderm.

We found that cohesivity was different among the gels so that Desirial was the least cohesive and Belotero was the most cohesive gel. Other HA gels were observed as partially cohesive. The resistance to stretch test confirmed the cohesivity results and Belotero had the most significant resistance. Microscopic examination of the HA gels showed HA particles of varying distribution and size. Belotero and Desirial were the gels with no particles visible under the microscope.

Simple and inexpensive laboratory tests help to understand the way that they can affect the specific gel performance, and may be beneficial for physicians to decide on the best product for a particular therapeutic indication.

To Report a case of blindness due to hyaluronic acid filler injection.

 A 28-year-old female patient was referred to our clinic with complaints of vision loss in the left eye, which occurred one hour after hyaluronic acid filler injection for correction of detachment trough hollowness. In the ophthalmologic examination, relative afferent pupillary defect (RAPD) was positive in the left eye. Dilated fundus examination of the left eye revealed retinal edema and whitening in the inferotemporal macula consistent with a branch retinal artery occlusion. Cherry red spot was noticed in the central macula, along with scattered intraretinal hemorrhages. Fluorescein angiography demonstrated the blockage of the inferior branches of retinal circulation in the left eye and areas of patchy choroidal non-perfusion were revealed. Fluorescein angiography also demonstrated delayed filling in some of the proximal arteries in the left eye, but the pattern of filling was patchy. The Optical Coherence Tomography of the left eye demonstrated retinal inner layers edema starting just below the fovea. The patient underwent anterior chamber tap and ocular massage in primary hours of symptoms and, then, treatment with aspirin, systemic corticosteroid, acetazolamide, and nitroglycerin for one month. The visual acuity of the eye was No Light Perception (NLP) without any improvement after 3 days and even after 6 months after the treatment.

It is necessary to describe this complication, as well as its treatment process for patients, who undergo filler injection for cosmetic purposes. Additionally, the patients should be trained for an appropriate and prompt arrival with the least visual impairment.