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عضویت

جستجوی مقالات مرتبط با کلیدواژه "fullerene c60" در نشریات گروه "پزشکی"

جستجوی fullerene c60 در مقالات مجلات علمی
  • Fariba Namdar, Farideh Bahrami, Zahra Bahari, Bahram Ghanbari, Shima Shahyad, MohammadTaghi Mohammadi*
    Introduction

    Diabetic neuropathy is a common complication of diabetes mellitus. It is associated with nerve damage due to oxidative stress and high levels of pro-inflammatory mediators. In the present study, we examined the anti-nociceptive effects of Fullerene nanoparticle, as a potent anti-oxidant, during diabetic neuropathy.

    Methods

    Diabetes mellitus induced through injection of streptozotocin (STZ) (40 mg/kg). Four groups were used in the study as follows: the control, control+fullerene, diabetes, and diabetes +fullerene groups. All four groups received sesame oil. Treatment rats received fullerene C60 (1mg/kg/day) for 9 weeks by intra-gastric gavage. Then, cold allodynia, histology, and tumor necrosis factor-α (TNF- α) protein expression of the hippocampus were measured 9 weeks after injection of STZ.

    Results

    Our data revealed that STZ induces cold allodynia in both hind paws and increases the TNF- α protein expression in the hippocampus. Furthermore, STZ induces neural degeneration in the hippocampus. Additionally, fullerene C60 significantly attenuated cold allodynia and TNF- α protein expression. Also, fullerene C60 has neuro-protective effects on hippocampal neurons. However, fullerene C60 did not significantly reduce serum glucose levels in diabetic animals.

    Conclusion

    Our data suggest that fullerene C60 likely suppressed pain, and neural loss by inhibitory effects on TNF- α protein expression in the hippocampus during diabetes.

    Keywords: Fullerene C60, Diabetic Neuropathy, TNF-α, Hippocampus
  • Mehri Farhang Ranjbar, Shima Shahyad, Fariba Namdar, Ali Noroozzadeh, Zahra Bahari, MohammadTaghi Mohammadi*
    Background and Objective

    Occurrence of oxidative stress in uncontrolled diabetes mellitus affects spermatogenesis and the testicular functions. As the promising antioxidant activities of fullerene C60 nanomaterial have been demonstrated by previous reports, the current study aimed to determine the fullerene C60 effects on the markers of oxidative stress damage in testes of streptozotocin-induced diabetes in rats.

    Materials and Methods

    To perform the current study, 32 male Wistar rats were assigned to four groups (each group, n=8) as follows: two control (normal and diabetic) and two treated (normal and diabetic) groups. Streptozotocin at dose of 45 mg/kg (i.v. injection) was used to induce diabetes at the beginning of the test. Treated rats orally received fullerene C60 (1 mg/kg/day) for 8 weeks. The markers of oxidative stress damage were assessed in the testes at the end of the study, including malondialdehyde (MDA) and glutathione (GSH) contents as well as superoxide dismutase (SOD) and catalase (CAT) activities. One-way ANOVA and Tukey’s post-hoc test were used to analyze the data.

    Results

    Blood glucose level was not altered in the fullerene-treated normal and diabetic animals. Diabetes induction increased MDA level, but decreased CAT activity in the testes of diabetic animals compared to the normal animals. Administering fullerene C60 significantly decreased MDA content and increased the activity of CAT in the testes of diabetic animals compared to the untreated diabetic rats. Fullerene C60 administration in normal animals also decreased the activity of SOD in the testes.  

    Conclusion

    According to our findings, fullerene C60 nanoparticle could reduce oxidative stress damage in diabetic condition in the rat testicular tissue probably through potentiating the antioxidant defense system.

    Keywords: Diabetes mellitus, Testicular damage, Fullerene C60, Antioxidant capacity, Oxidative stres
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