جستجوی مقالات مرتبط با کلیدواژه « galega officinalis » در نشریات گروه « پزشکی »

The present study aimed to investigate the potential effects of the combined herbal capsule (CHC), as a nutritional supplement, on glycemic indices (GIs) and lipid profile (LP) of patients with type 2 diabetes mellitus (T2DM).

Following a randomized, single-blind, placebo-controlled clinical trial, the current study was conducted on 80 cases with T2DM who were randomly assigned into two groups of treatment (CHCs; n = 40) and control (placebo; n = 40). Both groups received the intervention (500 mg capsules) twice a day for three months, without changes in the previous dose of oral anti-hyperglycemic drugs. The GI and LP levels were measured before the intervention and three months later to investigate the potential efficacy of the interventions.

For those in the intervention group, the mean GI [i.e., fasting blood sugar, two hours postprandial (2hpp), and HbA1c] was significantly different after 3 months (P < 0.05). The GI- and LP-related outcomes (TG, LDL-C except for TC) were improved after 3-month of receiving the intervention compared to the control group; however, the observed improvement was no statistically significant (P > 0.05). The HDL-C level was also significantly improved in the intervention group compared to the control group (P < 0.05).

This study demonstrated that receiving CHCs could improve GI and LP levels (TG, LDL-C, and HDL-C, except for TC), which indicates its potential to control T2DM. Moreover, no significant side effect was observed in the intervention group. It can be argued that the use of CHCs, as adjuvant therapy, in combination with conventional hypoglycemic and lipid-lowering drugs, as well as following a modified lifestyle, not only can significantly enhance glycemic control but also may prevent T2DM complications.

Diabetes is related with the higher blood levels of liver enzymes and inflammatory factors.  Galega officinalis is used as a medicinal plant for treatment of diabetes traditionally. In this work, silver nanoparticles (Ag-NPs) were synthesized with green method using Galega officinalis extract. The synthesized green Ag-NPs were characterized completely. Intact or diabetic rats receieved intraperitoneal injection of saline or 2/5mg/Kg  green synthesized Ag-NPs. Mean serum levels of glucose,  hepatic enzymes and hematological parameter were determined. Gene expression of tumor necrotic factor alpha (TNF-α) was done by real-time PCR.   Synthesis of green synthesized Ag-NPs was confirmed by FT-IR, XRD and UV-vis analyses. The FESEM and TEM images showed spherical Ag-NPs with size of 25 nm. The hypoglycemic influence of Ag-NPs using Galega officinalis extract is reported for the first time in this study. Blood concentration of liver enzymes, urea, glucose, white blood cells count and TNF-α mRNA levels in visceral adipose tissue significantly declined in diabetic rats receiving Ag-NPs. The synthesized Ag-NPs using Galega officinalis extract may improve complication of diabetes via preventing liver hepatocyte damage and reducing inflammatory factors.

This study aimed to evaluate the anti-oxidative potential of Galega officinalis extract on oxidative damages in the testes and sperm parameters of diabetic rats. In this experimental study, 32 male Wistar rats were segregated in 4 groups: Control, Diabetic control, Diabetic treated with G. officinalis extract and healthy group that received G. officinalis extract. An instillation of distilled water was performed in the control and diabetic groups. Also, treatment groups received Galega extract (50 mg/kg body weight) for 8 weeks. After treatment period all of subjects were anesthetized, their blood samples were taken, the serum level of insulin and glucose were measured then the testicles and epididymis were removed and sperm parameters and oxidative stress markers were assessed. Treatment of diabetic rats with G. officinalis extract significantly increased the Johnson score and diameter of seminiferous tubule as well as reduced the glucose plasma levels (P = 0.001) and increased the insulin levels (P = 0.001). Furthermore, during diabetes an upsurge in the level of malondialdehyde (MDA) and a decrease in the levels of superoxide dismutase (SOD) and catalase (CAT) enzymes activity were observed in the testes. Administration of G. officinalis extract (50 mg/kg BW) significantly rectified these parameters (P < 0.05). Moreover, the sperm parameters decreased in the diabetic group, while the use of G. officinalis significantly improved the mentioned disorders in the treatment groups (P < 0.05). The results of this study confirm the antioxidant role of hydroalcoholic extract of G. officinalis in the improvement of the testicular oxidative damage caused by diabetes.

  The antioxidative role of Galega officinalis extract has been reported in several studies. However, this experimental study was designed in order to investigate the impacts of G. officinalis extract against parameters, such as histological, hormonal, and oxidative stress parameters, which were induced by ovarian torsion/detorsion. Adult female Wistar rats (n = 28) were randomly divided into 4 groups including sham (G1), ovarian torsion for 3 hours then-after detorsion (G2 or TD), ovarian torsion-detorsion orally received 50 mg/kg extract of G. officinalis (G3 or TDGO), healthy rats orally received 50 mg/kg hydroalcoholic extract of G. officinalis (G4 or GO). Ten days after torsion-detorsion, rats were sacrificed and their ovaries, and their blood levels of hormones including estrogen and testosterone, as well as some oxidative stress
markers were assayed. The structure of ovaries in TD groups of the study showed a notable change compared to other groups. The serum levels of superoxide dismutase (SOD) and glutathione peroxidase (GSH), and also estrogen significantly decreased in TD group, while treatment with G. officinalis could prevent from decreasing mentioned parameters. Furthermore, although torsion-detorsion led to increasing the serum level of malondialdehyde (MDA), it was decreased after administration of G. officinalis. Obtained results showed that G. officinalis could be useful in elevating the estrogen level, reducing the oxidative stress marker (i.e. MDA) and ovarian tissue damages induced by torsion-detorsion.

Polycystic ovary syndrome (PCOS) has been considered as one of the most common endocrine diseases among the females in their regenerative age with a prevalence range of 5 to 21%. However, the purpose of the present study was to investigate the protective effect of Galega officinalis on metabolic as well as hormonal parameters in a rodent model of PCOS.
Thirty-two Wistar female rats were used (n=8/group) in the study consisting of healthy control and experimental groups. The experimental groups were divided into 3 subgroups, including rats with PCOS which received no treatment (G1), PCOS group in which G. officinalis extract was administered daily at a dose of 200 mg/kg/orally (G2) for 2 weeks, and PCOS group in which G. officinalis extract was administered daily at a dose of 400 mg/kg/orally (G3) for 2 weeks. In all experimental groups, a single intramuscular injection of estradiol valerate led to inducing PCOS. After the end of treatment period, rats in all of the studied groups were anesthetized with ketamine/xylazine (5/1 mg/kg), then the blood samples obtained and their serum samples were applied for testing the fasting blood sugar (FBS), insulin, aromatase, and follicle-stimulating hormone (FSH), luteinizing hormone (LH), testosterone, and estrogen. The ovaries of rats were removed and fixed for histopathological examinations.
The serum levels of FBS, insulin, LH, FSH, and testosterone significantly increased in G1 in comparison to healthy rats (P It seems that the extract of G. officinalis has a beneficial effect on the levels of the LH, FSH, testosterone, estradiol, aromatase, FBS, and insulin in alleviating the complications of PCOS.

Diabetes mellitus (DM) is impairing secretion of insulin or resistance to insulin. Herbal medicine plays an important role in the management of DM. We aimed to test antidiabetic effects of Galega officinalis on diabetic rats.
Twenty-eight male Wistar rats were randomly divided into 4 groups (n=7). Diabetes was induced by streptozotocin (STZ) (50 mg/kg). Diabetic rats were calcified into a diabetic control group (DC), DHEG group (50 mg/kg hydroalcoholic extract of G. officinalis), DG group (5 mg/kg glibenclamide). After 20 days, rats" blood samples, kidney, liver, and pancreas were kept in -70°C to test blood levels of glucose, insulin, lipid profile, some oxidative stress markers and antioxidant enzymes.
The fasting blood sugar (FBS) levels in the normal, DHEG, and DG groups were significantly lower than the DC group (P The results of the present study indicated that G. officinalis could be beneficial for the treatment of diabetes through improving tissue sensitivity to insulin and preventing tissue damages.