جستجوی مقالات مرتبط با کلیدواژه "global" در نشریات گروه "پزشکی"
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مقدمه
پرداخت به روش گلوبال یکی از روش های پرداخت به بیمارستان ها است. در برخی از اعمال جراحی گلوبال، هزینه صورت حساب کمتر و در برخی دیگر بیشتر از تعرفه مصوب گلوبال است؛ این مسیله زیان مالی برای سازمان های بیمه گر و بیمارستان ها به همراه دارد. هدف از انجام این پژوهش، بررسی هزینه صورت حساب پرونده های گلوبال زایمان است.
روش هااین مطالعه توصیفی-تحلیلی در سال 1400 انجام شده است. در این پژوهش، هزینه صورت حساب کلیه پرونده های زایمان (طبیعی و سزارین) بیمه سلامت در سه بیمارستان تخصصی زایمان استان تهران (الف، ب و ج) با تعرفه گلوبال مصوب مقایسه شده است. داده های مورد نیاز از داشبوردهای سازمان بیمه سلامت استخراج و در نرم افزار اکسل جمع آوری شده اند. تحلیل داده ها با نرم افزار SPSSنسخه 20 انجام گرفته است.
یافته هادر این مطالعه، 3742 پرونده زایمان بررسی شده اند که 35 درصد آن ها زایمان طبیعی و 65 درصد سزارین بوده اند. نتایج نشان داد که هم در زایمان طبیعی و هم در سزارین، هزینه صورت حساب در بیمارستان الف بالاتر از تعرفه مصوب است؛ در حالی که در دو بیمارستان دیگر کمتر از تعرفه مصوب بود. همچنین، تعداد روزهای بستری واقعی سزارین در هر سه بیمارستان کمتر از تعرفه مصوب بود.
نتیجه گیریمحاسبه هزینه صورت حساب پرونده های زایمان به روش گلوبال برای بیمارستان الف فاقد توجیه اقتصادی است؛ لذا بهتر است این بیمارستان تمرکز بیشتری بر مدیریت هزینه های خود داشته باشد. علاوه بر این، تعرفه مصوب تخت-روز گلوبال در زایمان طبیعی و سزارین بیش از تعداد روزهای بستری واقعی بیماران بود؛ بنابراین این موضوع نیازمند بازنگری شورای عالی بیمه است.
کلید واژگان: : گلوبال, زایمان طبیعی, سزارین, تعرفه, شواریعالی بیمهIntroductionGlobal reimbursement is a hospital payment method. In some global surgeries, the billing cost of treatment differs from the tariff set by the Supreme Council of Insurance, leading to financial losses for hospitals or insurance companies. This study compares the billing costs of childbirth services with the approved tariffs.
MethodsThis descriptive-analytical study examined the billing costs of all childbirth cases (natural and cesarean section) covered by health insurance at three specialized maternity hospitals (A, B, C) in Tehran province in 1400. Data were sourced from health insurance company dashboards, compiled in Excel, and analyzed using SPSS software.
ResultsThe study evaluated 3,742 childbirth cases, with 35% being natural births and 65% cesarean sections. The comparison between billing costs and approved tariffs showed that Hospital A's costs for both natural and cesarean childbirths exceeded the set tariffs. However, the billing costs in the other two hospitals were below the approved tariffs. Additionally, the actual hospitalization days for cesarean sections were shorter than those covered by the tariff in all three hospitals.
ConclusionThis study highlights variations in childbirth billing costs compared to the approved global tariffs across different hospitals. These findings underline the necessity of cost control in hospitals and suggest a need to revise the approved tariffs to align with the actual hospitalization duration for patients.
Keywords: Global, natural childbirth, cesarean section, tariff, Supreme Council of Insurance -
Background
Strict adherence to safety precautions and, most importantly, social distancing and isolation of people infected with the Coronavirus disease-19 (COVID-19) virus have considerably affected the daily life activities of individuals and overshadowed their routine lifestyle. We conducted a systematic review to provide evidence-based information for clinicians, health policymakers, and social workers in developing useful interventions to effectively mitigate the adverse impacts of the pandemic on people’s life and health condition.
MethodsIn this systematic review and meta-analysis, studies assessing quality of life (QOL) among the population during the COVID-19 pandemic were searched in four main databases and Google Scholar from the onset of the epidemic to May 2021 with Mesh terms of quality of life and Covid-19.
ResultsWe included 23058 people who participated in 33 studies; the total quality of life score was estimated at 59.45 (95% CI, 56.33-62.58). Based on the analysis, for each year added to participants’ age, their quality of life score was reduced by -0.3%. Furthermore, a significant association between gender and QOL was affirmed, indicating a more favorable condition among men. The highest score of QOL was reported in AMRO at 66.77 (95% CI, 60.55-73) and WPRO at 64.79 (95% CI, 59.30-70.28), respectively, while SEARO with 47.95 (95% CI, 47.67-48.23) got the lowest score.
ConclusionOur review robustly recommends the necessity for community health promotion programs to be implemented in vulnerable community segments and adds corresponding knowledge to the existing literature about the status of quality of life in people with different socio-demographic characteristics living in different regions worldwide.
Keywords: COVID-19, Global, people, Quality of life, Systematic review -
The reduction of preventable deaths from non-communicable diseases, including cancers, is one of the main targets of universal health coverage. Not only there is a shortage of financial resources for universal health coverage for cancer patients in many countries, but also there are many challenges in the continuity and the quality of care. There are disparities rooted in both providers’ and patients’ behavior at the time of care. Unmet needs for information on treatment and prognosis, inadequate cost coverage of care, and inadequate support for other living costs are contributing factors to poor prognosis in cancer patients, especially in cases with advanced stages and those living in low-income countries. There is a need for a comprehensive, holistic approach to the care of cancer patients considering the patients’ socioeconomic and cultural status and the institutional status of the providers.
Keywords: Global, Universal Health Coverage, Oncology -
Context
Although the current literature suggests the significant impact of the COVID-19 pandemic on nosocomial infections, evidence is still scarce in this regard.
ObjectivesThe present study aimed to systematically review the current literature to estimate the prevalence of hospital-acquired infections (HAIs) and their determinants during the COVID-19 pandemic.
MethodsA comprehensive search was conducted via electronic databases such as EMBASE, Google Scholar, Scopus, PubMed, and Web of Science from the onset of the COVID-19 pandemic until the end of June 2021. To estimate the pooled prevalence of nosocomial infections, the random effects model was used.
ResultsThe prevalence of HAIs during the COVID-19 pandemic was estimated at 15% (95% CI: 9 - 24). COVID-19 infection accounted for the highest infection rate in patients with HAIs (63%; 95% CI: 43 - 75), followed by bloodstream infections (39%; 95% CI: 56 - 24). Among the common organisms that infected patients with HAIs, coronavirus had the highest rate (63%; 95% CI: 43 - 75), followed by Enterococci and Enterococcus, respectively. In addition, positive significant correlations were observed between the prevalence of nosocomial infections, age, and length of hospital stay (P < 0.05).
ConclusionsAccording to the results, nosocomial infections are an important consequence of the COVID-19 pandemic, particularly in the elderly and high-risk populations with prolonged hospital stay. Therefore, the early detection of infected individuals could be a key step toward improving the quality of response to the current pandemic.
Keywords: COVID-19, Nosocomial Infection, Global, Systematic Review, Meta-analysis -
Background
Behcet’s disease is a chronic fatal illness with a relapsing remitting nature and significant organ-threatening morbidity and mortality. The aim of this research was to examine studies which were conducted on investigation of prevalence of quality of life among patients with Behcet’s disease.
MethodsA total of 13 articles were extracted from four main databases including PubMed, EMBASE, Scopus, and Web of Science from the onset of 2000 to January 2021. All studies published in English with the purpose of examining quality of life (QOL) among patients with BD or investigating its main determinants were included.
ResultsTotally, 1137 BD patients participated in 13 studies. Based on random effect analysis, the total score of physical health-related QOL was 46.7 (95% CI=41.26 to 52.13) and the total score of mental health-related QOL was 49.01 (95% CI=43.83 to 54.18) representing a moderate level of QOL among BD patients. Furthermore, weighted effect size analyses showed a significant correlation between QOL and variables such as patients’ age, gender, disease duration and depression (pvalue: 0.00).
ConclusionAs the symptoms of BD worsen over time, patients confront with more severe body pain, mobility restrictions, and difficulties in chewing, eating, speaking and swallowing which negatively affect social interactions of patients and reduce their QOL. Furthermore, depression was proved to act as a deteriorating factor for HRQOL among BD patients. Thus, patients need to be psychologically supported by a specialized team and be informed during the course of treatment to gain useful information about the disease, treatment approaches and coping strategies.
Keywords: Global, health-related quality of life, Behcet’s disease, systematic review -
BackgroundWe aimed to estimate the global prevalence of HIV, as well as cross-countries comparison in people who are in prison.MethodsWe systematically assessed published studies reporting HIV prevalence among prisoners in the world. We searched international datasets banks, including PubMed, SCOPUS, Cumulative Index to Nursing and ISI web of science along with local databases and included original articles reporting data on the prevalence of HIV from 1980 to 2017.ResultsWe included 72 studies that reported HIV prevalence for 2,275,930 adult male and female prisoners. The pooled estimate of HIV prevalence was 3.4% (95% CI 3.2%-3.6%); however, the prevalence of HIV across individual studies varied considerably (ranging from 0 in Bosnia and Herzegovina to More than 20% in Iran, Zambia, Spain) and statistical heterogeneity was substantial (I2=0.99, Q=121; P<0.0001). The prevalence of HIV among prisoners in the continents Asia, Africa, North America and Europe was estimated as 3.0% (95% CI 3.3%-4.3 %), 6% (95% CI -0.0%–2.0%), 4% (95% CI 3.0%-4.0%), 5.0% (95% CI 0.0%–11%), respectively.ConclusionProtecting prisoners’ health protects general public health. Successful HIV preventive measures in prisons include provision of HIV education and information; clean needles and syringes; drug treatment; and condoms. Governments have a moral and ethical obligation to prevent the spread of HIV/AIDS in prisons and to provide compassionate care, treatment and support for those infected.Keywords: HIV, Global, Systematic review, Meta-analysis, Prevalence, Prisoners
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مقدمهبیماری بروسلوز شایع ترین بیماری مشترک بین انسان و دام است که به عنوان یک تهدید بالقوه بهداشت عمومی محسوب می گردد. استفاده از سیستم اطلاعات مکانی کمک شایان توجهی به مدیران و تصمیم گیران حوزه سلامت عمومی جامعه در خصوص طراحی، اجرا و نظارت بر برنامه های کنترلی می کند.روشدر این مطالعه توصیفی- مقطعی به منظور تعیین نوع الگوی سالانه بیماری از آماره عمومی موران، برای شناسایی مناطق پرخطر از آماره های محلی موران و Getis-Ord Local G* و برای مقایسه الگوی مکانی بیماری براساس میزان بروز سالانه در هر دو سال متوالی از آماره موران تفاضلی استفاده شد.نتایجنتایج نشان داد که بیشترین موارد در بازه زمانی هفت ساله در دهستان های شهرستان ملایر و کمترین موارد در شهرستان های اسدآباد و تویسرکان و نواحی مرکزی و غربی استان قرار دارند. میزان بروز بیماری از سال 1388 تا 1393 افزایش و در سال 1394 کاهش یافته است. در خصوص تحلیل الگوی بیماری، الگوی همه سال ها به جزء سال 1391 خوشه ایتشخیص داده شد. خوشه های شناسایی شده توسط آماره های محلی موران و G* نشان دادند که خوشه های با نرخ بروز بالا و نقاط داغ در جنوب شرقی استان همدان قرار داشتند. نتایج حاصل از آماره موران تفاضلی نشان از ایجاد مناطق پرخطر جدید با گذر زمان در سطح استان دارد.نتیجه گیریبا مقایسه الگوی مکانی بیماری برای سال های مختلف می توان گفت برنامه های کنترلی فعلی کارایی لازم را نداشته و نیازمند یک بازنگری کلی می باشند. نتایج حاصل از این مطالعه در تعیین نقطه شروع برنامه های آتی و بررسی میزان اثربخشی آن ها قابل استفاده می باشد.کلید واژگان: تحلیل الگوی نقطه ای, بیماری بروسلوز, آماره های عمومی و محلی موران, آماره G*, آماره موران تفاضلی, استان همدانIntroductionBrucellosis is one of the most common zoonotic infections, which is considered as a potential public health threat. Geographical information system (GIS) can be a great help to managers and policy makers in the public health field for designing, implementing and monitoring control programs.MethodIn this descriptive cross-sectional study, the global Moran's I was used to determine the type of annual pattern of the disease, local Moran and Getis-Ord G * indices were used to identify the high risk areas and differential Moran's was used to compare the spatial pattern of the disease based on the incidence of annual incidence in the two successive years.ResultsAccording to the results, during a 7-year period, most of the cases had been located in Malayer County and the least in Asadabad and Tuyserkan counties (central and western areas of the province). The incidence rate of the disease rose from April 2009 to March 2014 and decreased during April 2014 to March 2015. According to the results of global Moran's, the pattern of disease was cluster in all years except for 2012. The clusters and hotspots detected by local Moran's I and G * were located in the southeast of the province. The results of differential Moran's I showed the emergence of new hazardous areas in the province over the study period.ConclusionBy comparing the spatial pattern of disease in different years, it can be said that the current control programs do not have the required efficacy and need a general overview. The results of this study can be used to identify starting points for future plans and to evaluate their effectiveness.Keywords: Point pattern analysis, Human brucellosis, Hamedan, Global, local Moran’s I, Getis-Ord G*, Differential Moran’s I
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There is growing awareness of the substantial global burden of surgical disease. Conditions treated effectively by plastic and reconstructive procedures make a large proportion of the global surgical diseases, and disproportionately affect individuals at the lower end of the economic spectrum. This article reviews the role of plastic surgery in global health, highlights the ongoing need for plastic and reconstructive surgery globally, and increasing efforts that have been made to meet these needs. There global shortage of plastic surgeons in low and middle income countries, but plastic surgery has a long tradition of humanitarian aid, has been a leader in global surgery development. Plastic and reconstructive surgical care has increasingly been shown to be cost effective and to have an immense impact on the economy of a region, delivering a substantial return on investment. More sustainable global surgical care is essential in future, requiring ongoing efforts from the plastic surgery community, greater recognition of the problems that can be addressed at policy level, and research to help guide policy-makers when facing the decision of allocating scarce resources. There is a fundamental role of plastic surgery in global health.Keywords: Plastic, Reconstructive, Surgery, Global, Health
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IntroductionThe objectives of this study were to provide an estimate of the prevalence of metabolic syndrome (MetS) and its components among women with PCOS; and calculate the odds ratio (OR) for MetS (using different definitions of MetS) in women with PCOS, compared to healthy controls.MethodsAll of the relevant databases were used to search for appropriate articles that were published during the period 2003-2016. We included observational studies (cross-sectional, comparative cross-sectional) among women who met the inclusion criteria. The random-effect models were used to pool the prevalence of MetS and its components among PCOS women. This model was also applied to the pooled OR assessing the association between MetS and PCOS.ResultsThe pooled prevalence of MetS among PCOS women was found to be 26.30% (95% CI: 23.6828.93), but varied from 7.10% (95% CI: 1.64-12.56) to 37.50% (95% CI: 28.84-46.16), depending upon the diagnostic criteria used. Low high-density lipoprotein cholesterol (HDL) - 61.87% (95% CI: 53.3170.43) and high waist circumference (WC)- 52.23% (95% CI: 43.8460.61) were the most common components of MetS in PCOS women. Compared to healthy controls, the overall pooled (OR) of MetS in PCOS patients was 2.09 (95% CI: 1.67-2.60), but this ranged from 0.31 (95% CI: 0.13-0.74) to 4.69 (95% CI: 2.09-10.52), depending upon the diagnostic criteria used.ConclusionWomen with PCOS had a much higher prevalence of MetS than was found among the healthy controls. Furthermore, as low HDL and high WC were the most common components of MetS in PCOS women, these two components specifically need to be addressed in prevention strategies.Keywords: Global, Metabolic Syndrome, Prevalence, Polycystic Ovary Syndrome, Meta-Analysis
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Solomon Benatars paper Politics, Power, Poverty and Global Health: Systems and Frames examines the inequitable state of global health challenging readers to extend the discourse on global health beyond conventional boundaries by addressing the interconnectedness of planetary life. Our response explores existing models of international cooperation, assessing how modifying them may achieve the twin goals of ensuring healthy people and planet. First, we address why the inequality reducing post World War II European welfare model, if implemented stateby-state, is unfit for reducing global inequality and respecting environmental boundaries. Second, we argue that to advance beyond the Westphalian, human centric thinking integral to global inequality and climate change requires challenging the logic of global economic integration and exploring the politically infeasible. In conclusion, we propose social policy focused changes to the World Trade Organisation (WTO) and a Green and Social Climate Fund, financed by new global greenhouse gas charges, both of which could advance human and planetary health. Recent global political developments may offer a small window of opportunity for out of the box proposals that could be advanced by concerted and united advocacy by global health activists, environmental activists, human rights activists, and trade unions.Keywords: Global, Planetary Health, Inequality, Politics, Greenhouse Gas
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In this commentary, we endorse concerns about the health impact of the trans-pacific partnership (TPP), paying particular attention to its mechanisms for investor state dispute settlement. We then describe the different, judgeled approach being advocated by the European Commission team negotiating the Trans-Atlantic Trade and Investment Partnership, arguing that, while not perfect, it offers significant advantages.Keywords: Social Determinants of Health (SDH), Trade, Investment Policy, Population Health, Global, Governance for Health
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Striking disparities in access to healthcare and in health outcomes are major characteristics of health across the globe. This inequitable state of global health and how it could be improved has become a highly popularized field of academic study. In a series of articles in this journal the roles of power and politics in global health have been addressed in considerable detail. Three points are added here to this debate. The first is consideration of how the use of definitions and common terms, for example poverty eradication, can mask full exposure of the extent of rectification required, with consequent failure to understand what poverty eradication should mean, how this could be achieved and that a new definition is called for. Secondly, a criticism is offered of how the term global health is used in a restricted manner to describe activities that focus on an anthropocentric and biomedical conception of health across the world. It is proposed that the discourse on global health should be extended beyond conventional boundaries towards an ecocentric conception of global/planetary health in an increasingly interdependent planet characterised by a multitude of interlinked crises. Finally, it is noted that the paucity of workable strategies towards achieving greater equity in sustainable global health is not so much due to lack of understanding of, or insight into, the invisible dimensions of power, but is rather the outcome of seeking solutions from within belief systems and cognitive biases that cannot offer solutions. Hence the need for a new framing perspective for global health that could reshape our thinking and actions.Keywords: Global, Planetary Health, Belief Systems, Values, Framing, Poverty, Power
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The last decade has ushered in a rapidly expanding global discussion regarding acellular dermal matrix (ADM) applications, economic analyses, technical considerations, benefits, and risks, with recent emphasis on ADM use in breast surgery. This study aims to evaluate global trends in ADM research using bibliometric analysis. The top nine Plastic Surgery journals were determined by impact factor (IF). Each issue of the nine journals between 1999 and 2013 was accessed to compile a database of articles discussing ADM. Publications were further classified by IF, authors geographic location, study design, and level of evidence (LOE, I-V). Productivity index and productivity share were calculated for each region. In total, 256 ADM articles were accessed. The annual global publication volume increased significantly by 4.2 (0.87) articles per year (pKeywords: Bibliometrics, Acellular dermal matrix, Trends, Global
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BackgroundThis study aimed to investigate dentists supply and practice patterns following the implementation of the global budget system in Taiwan.Materials And MethodsData of reimbursement claims, municipal socioeconomic status and dental manpower were collected from the National Health Insurance administration, the Ministry of Internal Affair, and the Ministry of Health and Welfare, respectively. A multivariate linear regression method was used for data analysis.ResultsA municipality that reported a higher percentage of tertiary educated population (t = 3.718, PConclusionThis study has demonstrated a stabilizing effect of the global budget system on dynamics of dental manpower in Taiwan. A relationship between HHI and dentists move‑out rate has been found. The relationship between municipal socioeconomic status and the density of dentists has also been confirmed. In addition, reduced utilization of amalgam restorations was accompanied by increased utilization of tooth‑colored material restorations. Further investigations are indicated.Keywords: Amalgam, composite resins, dentist, global, budget, health insurance, Herfindahl, Hirschman Index
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مقدمهنظام گلوبال از سال 1378 در ایران به اجرا درآمد و در حال حاضر جهت پرداخت در سطح دوم و سوم خدمت بکار می رود. در این نظام بیماران بر طبق 60 مورد از اعمال جراحی شایع طبقه بندی می شوند. یکی از انواع اعمال جراحی گلوبال، عمل جراحی پیوند کلیه است.از آن جا که پس از گذشت چندین سال از اجرای این طرح و تفاوت های معنادار مبالغ گلوبال و هزینه های واقعی اعمال جراحی انجام شده در مراکز درمانی، سوالات زیادی در اذهان مسوولان شکل گرفته است، این مطالعه با هدف مقایسه هزینه پیوند کلیه گلوبال با هزینه واقعی پیوند کلیه در بیمارستان امام رضا(ع) شهر تبریز صورت پذیرفت.روش کاراین مطالعه گذشته نگر و از نوع توصیفی- تحلیلی می باشد. اطلاعات کلیه اعمال جراحی پیوند کلیه (35 مورد) که در سال های 1388 و 1389 در بیمارستان امام رضا(ع) انجام پذیرفته بود به صورت سرشماری، از محل سیستم اطلاعات بیمارستان و پرونده های بیماران گیرنده و دهنده پیوند کلیه استخراج شد. اطلاعات به دست آمده وارد نرم افزار SPSS نسخه 17 شد و نتایج با استفاده از آمار توصیفی و آزمون آماری t زوجی تحلیل گردید.یافته هابا برآورد مابه التفاوت هزینه واقعی پیوند کلیه و هزینه گلوبال مشخص می شود که بیمارستان امام رضا (ع) در سال های 1388 و 1389 با انجام عمل پیوند کلیه به صورت گلوبال مبلغ 45/818665 هزار ریال زیان داشته است. میانگین، انحراف معیار هزینه ای گلوبال اعمال جراحی انجام شده 66/4040±14/3292 و میانگین انحراف معیار هزینه واقعی اعمال جراحی انجام شده 53/3± 58/56317 هزار ریال بود. بین هزینه خدمات انجام شده توسط بیمارستان مورد مطالعه برای عمل پیوند کلیه به صورت غیر گلوبال و هزینه گلوبال پرداخت شده توسط بیمه ارتباط آماری معناداری وجود داشت و هزینه های غیر گلوبال و واقعی به طور معناداری بزرگ تر از هزینه های گلوبال بودند (001/0 > p).نتیجه گیریسازمان های بیمه گر تنها متعهد به پرداخت تعرفه مصوب می باشند. تفاوت این هزینه ها بر مراکز آموزشی و درمانی تحمیل شده و موجب کاهش درآمد آن ها شده است که می تواند در درازمدت بر بازده کاری آموزشی و درمانی مراکز اثرات منفی داشته باشد. علت برخی از تفاوت ها بین هزینه های گلوبال و واقعی پیوند کلیه مربوط به مشکلات موجود در بیمارستان ها به خصوص مشکلات مدیریتی است و بقیه نیز مربوط به سازمان های بیمه گر و نحوه محاسبه هزینه گلوبال اعمال جراحی می باشد.
کلید واژگان: پیوند کلیه, هزینه, گلوبال, بیمارستانIntroductionGlobal system was implemented in Iran in 1999. This system is currently used to pay for the second and third level health services. In the global system، patients are classified according to the 60 cases of common surgical procedures including kidney transplantation. Several years after implementing this system، the differences between actual costs and global costs of the operations raised many questions. This study aimed to compare actual cost and global cost of kidney transplantation in Imam Reza hospital in Tabriz.MethodsIn this cross-sectional study، data on kidney transplant surgery were gathered via hospital HIS and all patients'' medical records undergoing kidney transplantation during 2009-2010 (35 patients). Data were analyzed using descriptive statistics and paired T-test in the SPSS-17.ResultsThe findings of the study showed that there was a loss of 818،665. 45 thousand Rials in the hospital in 2009-2010 due to implementing global costs system. The mean and standard deviation of global costs was 32927. 14±4040. 66 thousand Rials; and mean and standard deviation of actual costs was 56317. 58±3. 53 thousand Rials. There was a statistically significant relationship between the actual and global costs of kidney transplantation. The real cost (non-global) was significantly larger than the global costs (P <0. 001).ConclusionInsurance companies are only obligated to pay the approved Tariff. The difference between the costs and the income has been reduced in recent years، which may have a negative impact on efficiency of hospitals. The differences between the global and actual costs of kidney transplantation are due to management issues and insurance organizations performance.Keywords: kidney transplant, cost, global, hospital -
BackgroundAn appropriate animal model of ischemia stroke is essential for evaluation of different therapeutic methods. Two and four-vessel global ischemia models are one of the most common types of transient cerebral ischemia..ObjectivesIn this study, the morphology of rat hippocampal CA1 neurons in modified models of two and four-vessel ischemia and reperfusion were evaluated..Materials And MethodsIn this study, 20 Wistar rats were randomly divided into five groups. In group 2 and 3, both common carotid arteries were occluded for 10 minutes in either 3 or 24 hours of reperfusions, respectively. In group 4 and 5, both common carotid and vertebral arteries were occluded for 10 minutes in either 3 or 24 hours of reperfusions, respectively. Group 1 as control, underwent the whole surgery without any arteries occlusion. Hippocampi of the rats in all groups were processed and tissue sections were stained using the Nissl method. The morphology of CA1 neurons were studied under a light microscope and compared different groups..ResultsIn all groups ischemic changes were apparently observed in hippocampus CA1 neurons. In two-vessel occlusion model, after 3 and 24 hours of reperfusions, ischemic cells accounted for 14.9% and 23.2%, respectively. In four-vessel occlusion model, after 3 and 24 hours of reperfusions, ischemic cells accounted for 7.6% and 44.9% (P < 0.0001), respectively..ConclusionsModified four-vessel occlusion model resulted in significant ischemic changes after 24 hours of reperfusion in CA1 neurons of rat hippocampus..Keywords: Hippocampus, Brain Ischemia, Global, Rat
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