جستجوی مقالات مرتبط با کلیدواژه « hellp syndrome » در نشریات گروه « پزشکی »

Pregnancy-induced hypertension (PIH) is a serious pregnancy complication that contributes significantly to both maternal and neonatal morbidity and mortality. The study aimed to evaluate various hematological parameters associated with PIH and to identify early hematological parameters predictive of eclampsia and hemolysis, elevated liver enzymes, and low platelet count (HELLP) syndrome.

A total of 114 subjects were studied. Venous blood samples were collected to study hematological profile, including coagulation and biochemical analysis.

Of 114 subjects, 35 were categorized as gestational hypertension, 33 as mild preeclampsia, 40 as severe preeclampsia, and six as eclampsia. Eight cases progressed to HELLP syndrome. The mean hemoglobin level was 10.6+2.1 g/dl, which decreased significantly in PIH patients as the disease progressed (p=0.045). The mean platelet count was 191 + 84 x 109cells/L. The mean platelet count in PIH patients decreased significantly with disease progression (p=0.008). The mean prothrombin time and activated partial thromboplastin time were 13.12 + 1.33 and 33.62 + 6.34 seconds, respectively. These parameters also increased significantly with disease progression (p<0.05). Liver enzymes, creatinine, and uric acid levels increased significantly as the disease progressed (p<0.05).

Most of the hematological parameters changed as PIH progressed in severity. The mean levels of hemoglobin, platelet, and lymphocytes are lower in cases with PIH, while the mean prothrombin time and activated partial thromboplastin time are higher in these patients. These variables are sensitive and specific prognostic markers for patients with PIH.

Preeclampsia contributes significantly to maternal & perinatal morbidity and mortality.

To study maternal & fetal outcome in preeclampsia.

Case records of 168 women with preeclampsia, out of which 58 had severe preeclampsia were analysed. This retrospective observational study was conducted at B.J. government medical college, Pune, during period of 1st March 2020 to 30th June 2020.

Incidence of PE was 6.43.  Among study group 70% were primigravida & nearly 70% were >37 weeks of gestation. 15 (8.9%) patients developed eclampsia, 6(3.5%) developed abruptio placentae, 5(2.9%) had HELLP syndrome. PPH was noted in 22% cases. Prematurity, LBW & stillbirth was noted in 54(32%), 59(35%) and 7(4%) cases respectively. 54% Cases delivered by caesarean section. The adverse maternal outcome includes PPH, eclampsia, abruptio placenta, while for fetus prematurity and LBW which increased fetomaternal morbidity in patients of preeclampsia.

Although it is not possible to prevent PE & its morbidity, antenatal screening for early detection & timely intervention will help to improve pregnancy outcome.

HELLP syndrome is a multisystemic disorder characterized by elevated liver enzymes, hemolysis and low platelet count. If left untreated, it is associated with high risk of maternal and fetal mortality. It usually occurs in the third trimester of pregnancy but may sometimes occur after pregnancy. Herein, we report a patient with postpartum HELLP syndrome.

A 32-year-old woman (G2Ab1) with gestational age of 36 weeks and a history of hypothyroidism, multiple sclerosis, favism, gestational diabetes and pregnancy-induced hypertension was admitted to hospital due to labor pain. The patient underwent cesarean section and showed triad of postpartum HELLP syndrome. Fortunately, with timely diagnosis and appropriate intervention, the patient was discharged with good general condition after four days of hospitalization in intensive care unit.

Pregnancy-induced hypertension is a life-threatening condition for mothers. HELLP syndrome is often related to preeclampsia but can also occur as a stand-alone disorder. Absence of symptoms should not rule out this syndrome, and it is recommended to consider risk of postpartum HELLP syndrome during follow ups.

HELLP syndrome is characterized by hemolysis, elevated liver enzymes, and low platelet count; it probably shows a severe form of preeclampsia. This syndrome usually occurs in third trimester of pregnancy and may be associated with severe complications, including subcapsular liver hematoma, eclampsia, pulmonary edema, liver or renal dysfunction, and even maternal death. This study aimed to report a case of maternal death misdiagnosis of HELLP syndrome.

Case Report: 

A 28-year-old pregnant woman with gestational age of 28 weeks referred to an emergency ward because of epigastric pain, nausea, and vomiting. She was discharged after receiving outpatient treatment. The next day, she was referred to the hospital because of seizure, decreased level of consciousness, and hypertension. A cesarean section was performed immediately. Unfortunately, some hours after the surgery, cardiac arrest occurred and she died in intensive care unit (ICU).

 Nausea, vomiting, and epigastric pain in the late second or third trimester of pregnancy are among the significant symptoms which should be seriously taken into consideration. Therefore, it is recommended that a patient be hospitalized and precise evaluation be performed to rule out the life-threatening differential diagnoses, like HELLP syndrome, and to prevent dangerous complications which can lead to maternal death.

HELLP syndrome is a life-threatening complication of preeclampsia. We report a young pregnant woman with HELLP syndrome who was diagnosed, managed, and delivered in a timely manner.

A 23-year-old second gravida twin pregnant woman was referred to our clinic due to high blood pressure. After delivery, she experienced a hemolytic condition with elevated liver enzymes and thrombocytopenia, defined as HELLP syndrome. After confirmation of HELLP syndrome by laboratory tests, the patient underwent hemodialysis and plasmapheresis. 10 days later, she was discharged under good general condition.

Women with a history of HELLP syndrome are considered to have an increased risk of death. Therefore, this lifethreatening condition should be closely monitored and treated in a timely manner.