جستجوی مقالات مرتبط با کلیدواژه « hybrid » در نشریات گروه « پزشکی »

Due to the limited target volume and irregular body surface, irradiating the chest wall (CW) and lymphatic nodes is more challenging. IMRT and VMAT (volumetric modulated arc therapy) are two treatment delivery techniques that help to improve dose coverage and homogeneity while reducing irradiation to the heart and ipsilateral (I/L) lung. The use of a hybrid treatment planning approach for the ca-breast will impact the treatment plan. The hybrid planning system must be reviewed and compared to alternative treatment options for ca-breast cancer.
For 10 patients undergoing left-sided breast chest wall irradiation, the 3 distinct planning techniques (FiF [Field-in-field], IMRT, and Hybrid IMRT) were evaluated. A prescription dose of 40 Gy in 15 fractions was used for the planned target volume (PTV). To compare plans, dose-volume histograms (DVHs) were assessed for PTV and organs at risk.
D95% of PTV was 37.10 ± 0.48 Gy in FiF, but considerably raised to 39.32 ± 0.34 Gy and 38.39 ± 0.29 Gy in IMRT (p=0.01) and Hybrid IMRT (p=0.01).When compared to IMRT (0.981 ± 0.014) and Hybrid IMRT (0.970 ± 0.013) FiF plans have the lowest CI value of 0.931 ± 0.026. IMRT plans (0.087 ± 0.021) were found to be more homogeneous than other 2 planning techniques (0.111 ± 0.013 [FiF, p=0.016], 0.107 ± 0.021[hybrid IMRT, p=0.056]).
Hybrid IMRT treatment plans for the ca-breast are recommended because they provide superior and similar PTV dose coverage and OAR sparing compared to FiF and IMRT plans. Hybrid IMRT plans feature lower MU and BOT, as well as a smaller low dose volume in comparison to IMRT.

Quinazolinone and quinazoline have been shown different pharmacological activities, namely anticancer, anti?inflammatory, anti?hyperlipidemia, analgesic, antihypertensive, and antibacterial. On the other hand, molecular hybridization is a structural modification technique in the design of new ligands which consist of two or more pharmacologically active molecules in one structure. Therefore, due to the importance of the biological activities of quinazolinones for the development of new therapeutic agents, this review emphasizes current findings on various quinazolinone?based hybrids in medicinal chemistry. Moreover, it highlights the biological activities and structure?activity relationship of these hybrids.

The most significant motivations for designing multi-biometric systems are high-accuracy recognition, high-security assurances as well as overcoming the limitations like non-universality, noisy sensor data, and large intra-user variations. Therefore, choosing data for fusion is of high significance for the design of a multimodal biometric system. The feature vectors contain richer information than the scores, decisions and even raw data, thereby making feature-level fusion more effective than other levels.

In the proposed method, kernel is used for fusion in feature space. First, the face features are extracted using kernel-based methods, the features of both right and left irises are extracted using Hough Transform and Daugman algorithm methods, and the features of both thumb prints are extracted using the Gabor filter bank. Second, after normalization operations, we use kernel methods to map the feature vectors to a kernel Hilbert space where non-linear relations are shown as linear for the purpose of compatibility of feature spaces. Then, dimensionality reduction algorithms are used to the fusion of the feature vectors extracted from fingerprints, irises and the face. since the proposed system uses face, both right 7and left irises and right and left thumbprints, it is hybrid multi-biometric system. We c8arried out the tests on seven databases.

Our results show that the hybrid multimodal template, while being secure against spoof attacks and making the system robust, can use the dimensionality of only 15 features to increase the accuracy of a hybrid multimodal biometric system to 100%, which shows a significant improvement compared with unibiometric and other multimodal systems.

The proposed method can be used to search large databases. Consequently, a large database of a secure multimodal template could be correctly differentiated based on the corresponding class of a test sample without any consistency error.

We synthesized twelve hybrids, S-allyl Cysteine methyl, ethyl and propyl ester-based non-steroidal anti-inflammatory drugs and their structures were elucidated by spectroscopic analysis. The chemopreventive potential of all compounds was evaluated against SW480 human colon adenocarcinoma cells and the non-malignant CHO-K1 cell line. Among the tested compounds, hybrids 10b-c, 11b and 12b displayed the best anticancer activity with IC50 values between 0.131-0.183 mM and selectivity indices higher than 1 after 48 h of treatment. Selectivity indices were comparable to those reported for the reference drug, 5-fluorouracil (SI > 1). The SAR analysis showed that compounds with two carbon atom alkylic chains displayed the best activity (10b, 11b and 12b). Modeling studies including drug-likeness, bioactivity score and ADME/tox studies using online tools like molinspiration and Osiris suggested that these designed hybrids have a good pharmacological profile and can be considered as promising scaffolds for further studies in the search for new therapeutic alternatives to treat colorectal cancer.

High ideal hybrid intelligence of managers is among the factors that can improve employees’ organizational commitment. Therefore, this study aimed to determine the relationship between managers’ ideal hybrid intelligence and employees’ organizational commitment in the Vice Chancellors’ Headquarters of Tehran University of Medical Sciences. This was a descriptive-analytical and cross-sectional study conducted in 2017 - 2018. The research sample size consisted of 86 senior and middle-level managers selected through census method, as well as 181 employees, selected using the Kerjecie and Morgan table. The research tool was an ideal hybrid intelligence questionnaire consisting of 102 questions on cultural, moral and spiritual intelligence, and also Meyer and Allens’ organizational commitment questionnaire including 24 questions. Face validity and reliability of each questionnaire were confirmed by an expert panel and Chronbach’s alpha method. The data were analyzed by SPSS software, and descriptive results were shown through mean and standard deviation, and analytical results by inferential tests. The results showed that the ideal hybrid intelligence of the Vice Chancellors’ Headquarters managers and employees’ organizational commitment were at a desirable level. Also, there was a significant correlation between cultural, moral and spiritual intelligence as constituents of the ideal hybrid intelligence of managers and employees’ organizational commitment. We found that ideal hybrid intelligence may affect employees’ organizational commitment, but it should be mentioned that other forms of intelligence may also affect organizational commitment.

Several hybrid sensing materials, which are organized by interaction of organic molecules onto inorganic supports, have been developed as a novel and hopeful class of hybrid sensing probes. The hybrid silica-magnetic based sensors provide perfect properties for production of various devices in sensing technology. The hybridization of silica and magnetic NPs as biocompatible, biodegradable and superparamagnetic structures provides the opportunity to produce capable sensing materials. The fluorescence, electrochemical and calorimetric sensors based on silica-magnetic materials can be applied in quantitative detection of various analytes. This review touches upon a subject of the design and synthesis of different sensors based on magnetic-silica hybrid nanomaterials and discusses their applications for improved detection of analytes in environmental and biological fields.

Spiritual healing is a complementary and alternative treatment with different meanings in different cultures and religions. However, the concept has not been defined from the cancer patients’ points of view. The present study was done with the aim of concept analyses of spiritual healing from Iranian cancer patients’ viewpoints.

The study was done using a hybrid method at three phases including of theoretical study, field study, and final analysis. In the theoretical study phase and using the keyword “spiritual healing,” pertinent articles were searched in main databases. In the field study phase, ten cancer patients were interviewed, and in the final phase, the two other phases were analyzed. After determining features, antecedents, and consequences, a conclusive definition of spiritual healing from Iranian cancer patients’ viewpoints was proposed.

Spiritual healing from Iranian cancer patients’ viewpoints was featured with four themes, including connection with paranormal forces; effective, noninvasive, inexpensive, and efficient therapeutic method; a way to achieve piece, adaptation, and health and influenced by cultural and religious beliefs. Spiritual healing is a complementary and alternative treatment that helps careseekers to achieve health through paranormal forces and energies. As the findings showed and according to the participants’ viewpoints, the source of such forces and energies was divine force and the healers were mediums to transfer the energy.

The findings supported that religion and faith were the key elements of spiritual healing in the Iranian Islamic context.

We have synthesized a series of S-allyl cysteine ester-caffeic acid amide hybrids and evaluated them in order to determine their possible anticancer activity and selectivity in colorectal cancer, which is still one of the leading causes of morbidity and mortality worldwide. All compounds were tested against SW480 human colon adenocarcinoma cells and the non-malignant CHO-K1 cell line. Among the tested compounds, hybrids 6e, 9a, 9b, 9c and 9e exhibited the highest effect on viability (IC50 SW480-48h= 0.18, 0.12, 0.12, 0.11 and 0.12 mM, respectively) and selectivity (SI= 10.3, 1.5, >83.33, >90.91 and >83.33, respectively) in a time- and concentration-dependent manner. Besides, our results were even better as regards lead compounds (S-allyl cysteine and caffeic acid) and the standard drug (5-FU). Additionally, these five compounds induced mitochondrial depolarization that could be related with an apoptotic process. Moreover, hybrids 6e, 9a and 9e induced cell cycle arrest in G2/M phase, and compound 9c in S- phase, which suggests that these hybrid compounds could have also a cytostatic effect in SW480 cell line. The SAR analysis showed that hydroxyl groups increased the activity, besides, there was not a clear relationship between the antitumor properties and the length of the alkyl chain. Since hybrid compounds were much more selective than the conventional drug (5-FU), this make them promising candidates for further studies against colorectal cancer.

Triazoles and quinazolinones are important heterocyclic structures with diverse biological properties including cytotoxic, antibacterial, antifungal and anticonvulsant activities. Due to valuable cytotoxic effects of both triazole and quinazoline derivatives, in this study a series of quinazolinone-triazole hybrids were synthesized in a multiple-step reaction procedure. 3-Amino-quinazolinone derivatives were treated with chloroacetyl chloride in the presence of dichloromethane/triethylamine to afford 2-chloro -N-(4-oxo-2-quinazolin3 (3H)-yl) acetamide derivatives. The reaction of resultants with 4-mehyl-4-H-1, 2, 4-triazole-3-thiol in dry acetone and potassium carbonate led to the formation of final products. Synthesized compounds were evaluated for their cytotoxic effects against MCF-7 and Hela cell lines using MTT colorimetric assay. Amongst tested compounds, 6a showed the highest cytotoxic activity against MCF7 cell line at all tested concentrations while compounds 6b and 6c indicated mild cytotoxic effects against Hela cell line at highest tested concentration reducing cell viability about 40%. The IC50 values of tested compounds revealed that the MCF-7 is more susceptible to the compound 6a.

Social responsibility in nursing is a complex concept that is completely associated with the context and healthcare system of every society. This study was conducted to analyze the concept of nurse’s social responsibility in Iran.

This analysis was done using a hybrid model, which consists of three phases: a literature review in the theoretical phase, semi-structured interviews in the fieldwork phase, and combination of the results of the two previous phases in a final analytical phase.

The four main themes extracted in the theoretical phase included: “Multi-dimensional and comprehensive approach”, spirituality-based, learner-based and an evolutionary-process. In the fieldwork phase, all the themes obtained in the previous phase were confirmed, and one more theme emerged as “being relative”. In the final phase, with the combination of the results of two previous phases, the final definition of the concept was presented.

Clarifying the social responsibility of nurses and highlighting it in nursing will definitely lead to satisfaction in patients and clients, professional development and reduction of health care costs. Also, by identifying facilitators, inhibitors and social responsibility concepts, nursing managers and nursing educators will be able to design and implement their management and training activities based on scientific findings based on the findings that are necessary for the correct learning and implementation

Cancer is still one of the most invasive health problems around the world although many researches have been done in this field. Different kinds of drugs are developed and used to improve cancer therapy. Some evidence has shown that nonsteroidal anti-inflammatory drugs (NSAIDs) have anticancer activity in addition to anti-inflammatory effects. To improve the safety profile of NSAIDs and enhance anticancer potency, different strategies such as hybridization are used in several studies. Indomethacin is a lead compound in NSAIDs classes' demonstrated inhibitory activity for some malignancies including breast and ovarian cancer. Two kinds of hybrids were proposed and synthesized using diamine linkers via amid bonds: indomethacin-indomethacin (hybrid A) and indomethacin-methotrexate (MTX; hybrid B). To confirm the structures of newly synthesized hybrids, melting points, IR, H NMR were applied. The cytotoxic effects of synthesized hybrids against Hela and MCF-7 cancer cells were evaluated by MTT assay. The results showed that both hybrids were more cytotoxic than indomethacin and MTX alone.

The aim of this in vitro study was to assess antimicrobial efficacy of Acacia nilotica, Murraya koenigii (L.) Sprengel, Eucalyptus hybrid, Psidium guajava extracts, and their combination on Streptococcus mutans and Lactobacillus acidophilus.
The branches of four plants were collected, identified, and authenticated by a taxonomist. The plants were rinsed in water, healthy leaves were separated and shade dried over a period of 3–4 weeks. Soxhlet apparatus using ethanol was employed for extraction procedure. The combinations of plant extracts were prepared by mixing equal quantities of 10% solutions of each of these extracts. 0.2% chlorhexidine and dimethyl sulfoxide were used as positive and negative controls, respectively. The antimicrobial efficacy testing was done using agar well‑diffusion method under anaerobic conditions. The mean diameter of inhibition zone was computed and compared between different categories using one‑way analysis of variance and Tukey’s post‑hoc test. A qualitative assay was carried out to identify the various phytochemical constituents in the plants. The data was assessed by SPSS version 20. The statistical significance was fixed at 0.05.
All the plants extracts and their combinations inhibited S. mutans and L. acidophilus. However, the quadruple combination of A. nilotica M. koenigii (L.) Sprengel Eucalyptus hybrid P. guajava produced the maximum inhibition zone (23.5 ± 2.2 mm) against S. mutans. Although, 0.2% chlorhexidine produced the highest inhibition zone against L. acidophilus (18.8 ± 1.2 mm), A. nilotica extract produced maximum inhibition among the various plant extracts and their combinations (14.1 ± 1.8 mm).
All the individual plant extracts and their combinations were effective against S. mutans and L. acidophilus. These could be tried as herbal alternates to chlorhexidine. However, these in vitro results have to be further evaluated for any toxicity of the polyherbal combinations in animal models and effectiveness has to be assessed using in vivo studies on humans.

The prevalence of peptic ulcer disease in hemodialysis patients is more than the general population. They are also more prone to complications including upper gastrointestinal bleeding. The aim of this study was to compare the efficacy of 14 days hybrid regimen with 14 days triple therapy for Helicobacter pylori (H. pylori) eradication in hemodialysis patients.Forty hemodialysis patients with naïve H. pylori infection were randomized to receive either hybrid regimen (pantoprazole 40 mg + amoxicillin 500 mg, both twice a day during the first 7 days, followed by pantoprazole 40 mg + amoxicillin 500 mg + clarithromycin 500 mg + tinidazole 500 mg, all twice a day, for the second 7 days, or standard triple therapy including pantoprazole 40 mg, clarithromycin 500 mg, and amoxicillin 500 mg, all twice a day for 14 days. H. pylori eradication was assessed by fecal H. pylori antigen test 8 weeks after the treatment.All the patients completed the study. According to both intention to treat and per-protocol analyses, H. pylori eradication rates were 100% (95% confidence interval (CI): 100) in those who received hybrid therapy and 70% (95% CI: 69.4 – 70.8) in those who were treated by standard triple therapy (p=0.02). Severe adverse effects were not reported by any patient; however, mild adverse effects were more frequent in those who received standard triple therapy (p<0.05).Hybrid regimen could achieve ideal H. pylori eradication rates with low rates of adverse effects.

Phospholipids are distributed asymmetrically between inner and outerleaflets of the plasma membrane of live cells. Early during apoptosis, this asymmetry isdisrupted and phosphatidylserine becomes exposed on the outside surface of the plasmamembrane. There is little information about the effects of vitrification on apoptosis.

The aim of the present study was to evaluate the effect of vitrification onapoptosis of subfertile and fertile men.

In this study, semen samples were collected from subfertile(n=20) and fertile men (n=10) after 48h abstinence of intercourse. After semen analysisaccording to WHO criterias, each semen sample was divided into two portions. Firstportion was assessed by Annexin V-flous staining kit for showing apoptosis insubfertile and fertile men and second portion was assessed after vitrification-thawing.Results were analyzed by Paired t-test and Independent t-test.

After vitrification-thawing, mean percentage of apoptotic spermatozoa hasincreased 6 and 3 times in subfertile and fertile men respectively. This difference issignificant.

Vitrification-thawing could disrupted membrane asymmetry andcaused apoptosis. Therefore, it will cause reduction of functional spermatozoa in accessof Assisted Reproduction Technologies (ART).